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Product Name: 4-Nitrobenzyl Chloride
Chemical Formula: C7H6ClNO2
CAS Number: 100-14-1
Synonyms: p-Nitrobenzyl chloride, para-Nitrobenzyl chloride
Recommended Use: Intermediate for organic synthesis, pharmaceuticals, dyes
Manufacturer Details: Supplier address, phone, emergency contact
UN Number: 2811
EC Number: 202-819-0
REACH Registration Number: Available upon request
Classification: Acute toxicity (oral, inhalation, dermal), Skin and eye irritant
Signal Word: Danger
Hazard Pictograms: Skull and crossbones, exclamation mark
Hazard Statements: Toxic if swallowed, toxic by inhalation, harmful in contact with skin, causes skin and eye irritation, may cause respiratory irritation
Precautionary Statements: Wear eye and face protection, use in well-ventilated area, avoid breathing dust
Potential Health Effects: Burning sensation, cough, shortness of breath, headache, nausea
Environmental Hazards: Toxic to aquatic life with long-lasting effects
Additional Information: Prolonged or repeated exposure increases health risks
Chemical Name: 4-Nitrobenzyl Chloride
Chemical Identification: 100-14-1
Purity: Typically ≥98%
Impurities: Trace amounts of 4-nitrobenzyl alcohol, 4-nitrotoluene
Additives: No known stabilizers or inhibitors
Molecular Weight: 171.58 g/mol
Inhalation: Move person to fresh air, keep at rest, provide oxygen if breathing becomes difficult, seek medical attention
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water and mild soap, seek medical advice if symptoms occur
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present, continue rinsing, consult ophthalmologist
Ingestion: Rinse mouth thoroughly, do not induce vomiting, seek immediate medical attention
Symptoms and Effects: Burning in mouth or nose, pain, respiratory distress, skin redness, eye watering
Advice for Medical Personnel: Provide symptomatic and supportive treatment
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Direct water jet may spread chemicals
Specific Hazards: Emits hazardous vapors including nitrogen oxides, hydrogen chloride and carbon oxides
Protective Equipment: Self-contained breathing apparatus, full protective clothing
Special Procedures: Evacuate area, fight fire from safe distance, prevent chemical runoff into water sources
Personal Precautions: Use personal protective gear, avoid inhaling dust or vapors, ensure adequate ventilation
Environmental Precautions: Prevent further leakage or spillage, do not allow material to reach soil, sewers, or watercourses
Containment: Cover spills with inert absorbent stores such as vermiculite or sand
Cleanup Methods: Collect absorbed material in containers for disposal, wash spill area thoroughly with water and detergent, ventilate area
Disposal: Manage as hazardous waste according to local legislation
Safe Handling: Work in fume hood or well-ventilated area, avoid direct contact with product, do not breathe dust, practice hygiene after handling
Storage Requirements: Store in tightly sealed original containers, in a dry, cool, well-ventilated location, keep away from incompatible materials
Incompatibles: Strong oxidizers, strong bases, amino compounds
Storage Temperature: Store below 25°C, protect from light and moisture
Special Instructions: Post clear hazard signage, restrict access to trained personnel
Occupational Exposure Limits: No specific limit established; control to lowest feasible level
Engineering Controls: Use fume hood, provide mechanical exhaust, install eyewash and safety shower stations nearby
Personal Protection: Chemical-resistant gloves (nitrile), lab coat, apron, safety goggles, face shield, respirator with particulate filter in absence of proper ventilation
Hygiene Measures: Wash hands and face before eating or drinking, launder clothing after use, keep work area clean
Environmental Exposure Controls: Prevent chemical discharge into drains or waterways using secondary containment
Appearance: Pale yellow to light brown crystalline solid
Odor: Faint aromatic
pH: Not available
Boiling Point: 261°C
Melting Point: 74-76°C
Flash Point: 141°C (closed cup)
Autoignition Temperature: Data not available
Explosive Limits: Not determined
Vapor Pressure: Low at room temperature
Solubility: Insoluble in water, soluble in alcohol, ether, chloroform
Density: 1.35 g/cm³
Partition Coefficient (log Kow): 2.2 (estimate)
Viscosity: Data not applicable
Sublimation: Not applicable
Chemical Stability: Stable under ordinary conditions of use and storage
Incompatible Materials: Strong bases, strong oxidizers, amines, reducing agents
Conditions to Avoid: Excess humidity, heat, open flames, light
Hazardous Decomposition Products: Nitrogen oxides, hydrogen chloride gas, carbon oxides
Polymerization: No hazardous polymerization expected under normal use
Acute Toxicity: LD50 (oral, rat) ~196 mg/kg; inhalation and dermal toxicity also high
Skin Irritation: Causes irritation, redness, blisters with sufficient exposure
Eye Damage/Irritation: Causes serious eye irritation
Respiratory Sensitization: Prolonged inhalation causes respiratory tract irritation
Chronic Toxicity: Prolonged exposure may result in organ damage, risk not fully assessed
Carcinogenicity: Not classified by IARC, ACGIH, NTP, or OSHA
Mutagenicity: No data indicating mutagenic effects in humans
Reproductive Effects: Data not definitive for teratogenicity or fertility impact
Acute Aquatic Toxicity: Toxic to aquatic organisms, EC50 (Daphnia): 1.5 mg/l (48 h)
Chronic Effects: Persistent in aquatic environments, may bioaccumulate
Persistence and Degradability: Not rapidly biodegradable, risk to watercourses if released
Mobility in Soil: Low mobility due to low water solubility, binds to organic matter
Other Adverse Effects: Potential for long-term impacts on aquatic life even in small concentrations
Disposal Methods: Incineration in licensed chemical incinerator with flue gas scrubbing, never to landfill or household waste
Contaminated Packaging: Dispose as hazardous chemical waste, triple rinse before discarding
Compliance: Follow local, regional, and national regulations, use certified waste contractors
Advice: Keep records of disposal for regulatory oversight and environmental audits
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 4-Nitrobenzyl chloride)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Labeling Requirements: Toxic, environmental hazard
Special Precautions: Secure packaging, avoid mechanical shock, prevent temperature extremes
Transport Regulation Compliance: International transport as per ADR/RID, IMDG, ICAO/IATA rules
Inventory Status: Listed in US TSCA, EU EINECS, Canadian DSL, Japan ENCS
Chemical Safety Assessment: Conducted following REACH guidelines
Labeling: Compliant with OSHA Hazard Communication Standard (29 CFR 1910.1200), CLP Regulation (EC) No 1272/2008
Restrictions: Use permitted only in research, laboratory or licensed facilities
SARA Title III Sections 302/304/311/312/313: Regulated as acute toxic substance
California Proposition 65: Not listed
Other Regulations: Subject to chemical accident prevention and occupational health guidelines in many jurisdictions
