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Chemical Name: 4-Nitrobenzohydrazide
Synonyms: Para-Nitrobenzohydrazide, p-Nitrobenzohydrazide
Chemical Formula: C7H7N3O3
Molecular Weight: 181.15 g/mol
Appearance: Pale yellow to yellow crystalline powder
Manufacturer: Information available on manufacturer’s label
Recommended Use: Intermediate in chemical synthesis, laboratory reagent
Restrictions on Use: Not intended for food, drug, or pesticide applications
CAS Number: 619-34-3
Emergency Contact: Refer to facility protocol
Classification: Acute Toxicity (Oral, Category 4), Eye Irritation (Category 2A), Specific Organ Toxicity (Category 3)
GHS Label Elements: Exclamation mark for acute toxicity and irritant
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Use only outdoors or in well-ventilated area.
Potential Health Effects: Inhalation may irritate respiratory tract, ingestion may cause nausea or vomiting, direct skin or eye contact may cause irritation, chronic exposure effects not well studied yet
Component: 4-Nitrobenzohydrazide
Concentration: >98% by weight
Impurities: Trace amounts of residual solvents, unreacted materials possible
Additives: None reported
Other Ingredients: None significant
Inhalation: Move individual to fresh air. Give oxygen if breathing is difficult. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water for at least 15 minutes. Get medical assistance for persistent irritation or rash.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention if irritation continues.
Ingestion: Rinse mouth. Do not induce vomiting unless instructed by medical personnel. Drink water to dilute. Contact poison control or a medical provider immediately.
Most Important Symptoms: Irritation, nausea, respiratory distress, possible allergic reactions
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: High-pressure water jets
Specific Hazards: Thermal decomposition generates toxic gases like nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Self-contained breathing apparatus, chemical-resistant clothing, gloves
Precautions: Cool adjacent containers with water spray, move undamaged containers from fire area if safe, avoid direct contact with spilled material
Personal Precautions: Wear dust mask, protective gloves, goggles, and clothing suitable for hazardous chemical work
Environmental Precautions: Prevent contamination of soil, drains, surface and groundwater
Cleanup Methods: Sweep up without generating dust. Store in sealed container for later disposal. Ventilate affected area. Use damp cloth or mop for final cleaning.
Decontamination: Wash area with water and detergent. Dispose of cleaning materials as hazardous waste.
Safe Handling: Use only with adequate ventilation. Avoid creating dust and inhaling particles. Prevent contact with skin, eyes, and clothing. Practice proper hygiene.
Storage Conditions: Store in a cool, dry place. Keep container tightly closed and away from incompatible materials such as strong oxidizers and acids.
Storage Security: Keep away from children and unauthorized persons. Store in clearly labeled, corrosion-resistant containers.
Incompatible Materials: Strong oxidizing agents, strong acids, reducing agents
Control Parameters: No specific occupational exposure limits established for 4-Nitrobenzohydrazide. General dust exposure limits may apply (e.g., ACGIH TLV for particulates not otherwise regulated: 10 mg/m³ inhalable, 3 mg/m³ respirable)
Engineering Controls: Use laboratory fume hood or local exhaust ventilation
Personal Protective Equipment (PPE): Protective gloves (nitrile or neoprene), chemical safety goggles, lab coat or apron, particulate filtering respirator if dust is generated
Hygiene Measures: Wash hands after handling, do not eat, drink or smoke in work area, remove contaminated clothing and launder before reuse
Physical State: Crystalline powder
Color: Yellow/pale yellow
Odor: Slight or no odor
Odor Threshold: Not available
pH: Non-applicable (solid material)
Melting Point: 216–220°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Flammability: Non-flammable in solid form
Explosive Properties: No explosive properties noted
Vapor Pressure: Not determined (negligible at ambient temperature)
Solubility: Slightly soluble in water, soluble in organic solvents like ethanol and acetone
Partition coefficient (n-octanol/water): Not determined
Vapor Density: Not applicable
Decomposition Temperature: Above melting point
Chemical Stability: Stable under recommended storage conditions
Reactivity: Does not react under normal laboratory or storage conditions
Conditions to Avoid: High temperature, static discharge, ignition sources
Incompatible Materials: Strong oxidizers, reducing agents, acids
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, other potentially toxic vapors
Polymerization: No hazardous polymerization expected
Acute Toxicity: Oral LD50 (rat) ~500-2000 mg/kg; inhalation and dermal data not fully characterized
Skin Corrosion/Irritation: May cause irritation or rash on prolonged contact
Serious Eye Damage/Irritation: Causes eye irritation that may be severe
Respiratory or Skin Sensitization: Possible sensitizer, especially through inhalation or dermal exposure
Carcinogenicity: No classification available from IARC, NTP, or OSHA
Reproductive Toxicity: No data available
Mutagenicity: No reliable studies available
Other Information: Medical conditions aggravated by exposure include respiratory disorders, skin allergies
Ecotoxicity: Data gaps exist, but related compounds may be toxic to aquatic organisms
Persistence and Degradability: Not rapidly biodegradable in the environment
Bioaccumulative Potential: Potential for accumulation in aquatic organisms not fully studied
Mobility in Soil: Expected to have low mobility due to low water solubility
Other Ecological Effects: Spills pose risk for water contamination; local regulations dictate limits for discharge
Disposal Methods: Collect and arrange for disposal through licensed chemical waste contractor
Waste Codes: Not specifically listed; treat as hazardous laboratory waste
Container Disposal: Decontaminate if possible, otherwise treat containers as hazardous waste
Precautions: Do not discharge to environment, waterway, or sewer
Other Considerations: Follow all local, regional, national, and international regulations regarding waste disposal
UN Number: Not assigned
UN Proper Shipping Name: Chemical Not Otherwise Specified
Transport Hazard Class: Not classified as a hazardous material for transport
Packing Group: Not assigned
Environmental Hazards: Not considered a marine pollutant but avoid contamination
Transport Precautions: Protect from moisture, avoid physical damage, use secure containers
Special Precautions: Label packaging clearly with chemical name and hazard warnings
OSHA Status: Not specifically listed as hazardous, handle according to general chemical safety rules
TSCA Status: Listed
SARA Title III Sections 302/304: Not listed as an extremely hazardous substance
SARA Title III Sections 311/312: Acute health hazard
SARA Title III Section 313: Not listed
California Proposition 65: Not listed
WHMIS Classification (Canada): Classified under D2B (Toxic Material Causing Other Toxic Effects)
Other Regulations: Comply with all national, state, and local chemical handling and safety codes
