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Product Name: 4-Nitrobenzenesulfonyl Chloride
Synonyms: p-Nitrobenzenesulfonyl Chloride, NSC 4009
Chemical Formula: C6H4ClNO4S
CAS Number: 98-63-5
Recommended Use: Laboratory chemical, organic synthesis intermediate
Supplier Information: Contact details of distributor or chemical provider, with emergency contact phone number
Emergency Phone: Provided in case of accidental exposure or spillage for immediate assistance by qualified professionals
Restrictions: For research use only, keep away from food, feed and water sources
GHS Classification: Eye damage/irritation Category 2A; Skin irritation Category 2; Respiratory sensitizer Category 1
Signal Word: Danger
Hazard Statements: Causes skin irritation, causes serious eye irritation, may cause respiratory irritation, may cause allergic or asthmatic symptoms or breathing difficulties if inhaled
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust, wash skin thoroughly after handling, use in a well-ventilated area, wear protective gloves and eye/face protection, dispose of contents/container according to local regulations
Potential Health Effects: Irritation to eyes and skin, sensitization possible through inhalation
Environmental Effects: Harmful to aquatic life if released in significant quantities
Chemical Name: 4-Nitrobenzenesulfonyl Chloride
Concentration: 99% or higher by weight
CAS Number: 98-63-5
Impurities: Trace amounts of organic by-product trichlorinated and nitro compounds; not expected to alter toxicity profile significantly
Additives: None reported
Molecular Weight: 221.62 g/mol
Inhalation: Move exposed individual to fresh air immediately, check for breathing, provide oxygen if available and necessary, seek medical advice without delay
Skin Contact: Remove contaminated clothing swiftly, rinse affected areas with running water and mild soap for fifteen minutes, seek prompt medical attention if irritation occurs
Eye Contact: Flush eyes with low-pressure clean water for at least fifteen minutes, seek evaluation from an ophthalmologist regardless of symptom severity
Ingestion: Rinse mouth with water if substance is swallowed, do not induce vomiting unless directed by poison center or medical personnel, seek immediate medical help
Notes for Physicians: Monitor for delayed pulmonary edema, treat symptomatically, pay special attention to respiratory health
Suitable Extinguishing Media: Use dry chemical, foam, or carbon dioxide fire extinguishers, avoid water contact with chemical unless unavoidable due to risk of violent reaction
Specific Hazards: Releases noxious gases such as sulfur oxides, nitrogen oxides, hydrogen chloride when heated to decomposition
Protective Equipment: Wear self-contained breathing apparatus, full protective clothing including chemical-resistant gloves and boots
Advice for Firefighters: Approach fire from upwind to avoid hazardous emissions, use water spray to cool nearby containers and prevent pressure buildup, contain run-off to prevent contamination of waterways
Personal Precautions: Wear appropriate chemical-resistant gloves, splash-proof goggles, long-sleeved protective garments, work in a well-ventilated location or fume hood
Environmental Precautions: Prevent further leakage or spillage if safe to do so, keep material out of drains, surface and ground water
Containment and Cleanup Methods: Scoop up spilled substance into sealable containers using non-sparking tools, sweep or shovel up avoiding dust formation, wipe affected area with damp pads, dispose of in accordance with chemical waste regulations
Procedure for Large Spills: Isolate hazard area, restrict access, ventilate closed spaces before re-entry, consult with local hazardous material incident response teams if spill is significant
Precaution for Safe Handling: Avoid inhaling dust, do not ingest, minimize direct contact with skin, eyes, and clothing; always handle in areas with proper exhaust or fume hoods, monitor for vapor or dust generation, wash hands before eating or drinking
Conditions for Safe Storage: Store in tightly closed containers, in dry, cool, well-ventilated locations, keep away from incompatible materials such as strong bases, water, oxidizers and reducing agents
Incompatible Materials: Reactive towards water, alcohols, amines, strong bases and oxidizing agents
Packing Requirements: Use materials resistant to corrosion and moisture penetration, check container integrity regularly
Special Provisions: Label storage zones and provide access to emergency showers and eyewash stations nearby
Control Parameters: No specific regulatory occupational exposure limits established for this compound; minimize exposure as much as possible
Engineering Controls: Use local exhaust ventilation, maintain negative air pressure in storage and use areas, install mechanical air filtration systems, ensure easy access to emergency wash equipment
Personal Protective Equipment: Wear chemical splash goggles, face shield for large volumes, gloves made of nitrile or neoprene, full-length lab coats, antistatic footwear
Respiratory Protection: Use approved particulate respirators in absence of adequate ventilation, P2 or P3 grade recommended
Hygiene Practices: Avoid direct contact, launder contaminated clothing before reuse, keep separate work clothing and street clothing
Environmental Protection: Employ secondary containment and air filtration where emission risk is high, monitor storage areas for residue buildup and ventilation performance
Appearance: Pale yellow crystalline solid
Odor: Faint, characteristic aromatic, irritating
Melting Point: Approximately 137-140 °C
Boiling Point: Decomposes before boiling
Solubility: Partially soluble in common organic solvents (acetone, dichloromethane, chloroform), reacts with water producing heat and corrosive byproducts
Density: 1.67 g/cm³
Vapor Pressure: Not determined, expected very low at ambient temperature
pH: Not applicable due to reactivity with water
Partition Coefficient (log Pow): Not available
Other Data: Sensitive to moisture, will fume in humid air, degrades on exposure to sunlight
Chemical Stability: Remains stable under recommended storage and handling
Conditions to Avoid: Exposure to water, high humidity, strong sunlight, excessive heat
Materials to Avoid: Turns unstable if it contacts water, strong bases, alcohols and oxidizing agents, reacts violently with amines
Hazardous Decomposition Products: Produces toxic fumes of nitrous oxides, sulfur oxides, hydrogen chloride under combustion or decomposition
Polymerization: Not likely under normal conditions
Reactivity Profile: Strong chlorinating agent, reacts rapidly and exothermically with moisture, may corrode commonly used laboratory metals in damp conditions
Acute Toxicity: Limited oral and inhalation toxicity data, estimated LD50 (mouse, oral) between 200-500 mg/kg, marked irritation at low concentrations
Skin Corrosion/Irritation: Causes moderate to strong irritation, possible chemical burns on prolonged exposure
Eye Damage/Irritation: Severe eye irritant, risk of permanent damage on direct exposure
Respiratory Sensitization: Risk of sensitization or asthma on repeated inhalation
Chronic Effects: Possible skin and respiratory sensitizer, repeated low dose exposure may increase risk of dermatitis or hypersensitivity
Carcinogenicity/Mutagenicity Information: Not listed by IARC, ACGIH, NTP; long-term effects not thoroughly studied
Symptoms of Exposure: Shortness of breath, coughing, burning eyes, skin redness, blisters on direct contact, potential delayed respiratory distress
Aquatic Toxicity: Harmful to aquatic life, risk of acute toxicity at low concentrations for invertebrates
Persistence/Degradability: Organic component slowly biodegrades, but may produce persistent sulfonate residues, chlorinated breakdown products pose ecological risks
Bioaccumulative Potential: Potential exists due to chemical stability, but not studied in detail for aquatic food chains
Mobility in Soil: Reacts in moist soils, likely to convert to non-volatile byproducts bound to soil particles
Other Adverse Effects: Can cause significant pH shifts in water by releasing acids, classified as environmentally hazardous for industrial quantities
Material Disposal: Dispose as hazardous organic chemical waste, segregate from general laboratory waste streams, use licensed chemical incinerator with afterburner and scrubber
Container Disposal: Triple rinse empty containers with compatible solvent, puncture after rinsing, discard in accordance with local hazardous waste requirements
Sewage Disposal: Release to sewage systems strictly prohibited, consult local regulations
Precautions: Label all disposal units with compound and hazard type, isolate waste until proper disposal, keep contaminated absorbents sealed away from ignition or moisture sources
UN Number: UN 3261
Proper Shipping Name: Corrosive Solid, Acidic, Organic, N.O.S. (contains 4-Nitrobenzenesulfonyl Chloride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Marine Pollutant: Not classified as marine pollutant in small laboratory quantities
Special Transport Precautions: Keep containers upright, secured during transit, handle with gloves and goggles during loading and unloading
Regulatory Codes: Check current IATA/IMDG and land transport codes for local variations
OSHA Status: Considered hazardous under OSHA Hazard Communication Standard
TSCA Inventory: Listed
SARA Title III Sec. 313: Not subject to reporting
California Proposition 65: Not currently listed
Canadian DSL/NDSL: Listed on DSL
EU Regulation: Classified as hazardous under CLP Regulation (EC) No 1272/2008
Labelling Requirements: Strict hazard warning labels, R-phrases for skin, eye and respiratory irritant, safety phrases for protective equipment
Workplace Labelling: Ensure containers, storage areas and transfer equipment display hazard pictograms and precautionary codes as per local law
