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Product Name: 4-Nitroanisole
Chemical Formula: C7H7NO3
Synonyms: p-Nitroanisole, 1-Methoxy-4-nitrobenzene
Molecular Weight: 153.14 g/mol
CAS Number: 100-17-4
Recommended Use: Intermediate in organic synthesis, research applications
Restrictions: Not for household use; intended for laboratory and industrial use
Supplier: Chemical manufacturers and distributors specializing in organic laboratory reagents
Emergency Contact: Refer to specific supplier’s emergency numbers for chemical incidents
Classification: Acute toxicity, Category 4 (oral), Skin irritation, Category 2, Eye irritation, Category 2A, Specific target organ toxicity (repeated exposure), Category 2
Label Elements: Warning signal word, exclamation mark pictogram
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye irritation, may cause damage to organs through prolonged or repeated exposure
Precautionary Statements: Avoid breathing dust or fumes, wear protective gloves/clothing/eye protection, wash hands thoroughly after handling
Health Effects: May affect liver and kidneys with heavy or long-term exposure, irritates mucous membranes, can cause headache, dizziness, nausea if inhaled
Chemical Name: 4-Nitroanisole
Common Name: p-Nitroanisole
Concentration: Typically 97–100% pure
Impurities: Traces of related nitroanisole isomers or solvents used in synthesis
CAS Number: 100-17-4
EC Number: 202-818-5
Inhalation: Move victim to fresh air, keep at rest, seek medical attention if symptoms appear, supply oxygen if breathing becomes difficult
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water for at least 15 minutes, seek medical support if irritation persists
Eye Contact: Rinse eyes immediately with plenty of water for at least 15 minutes, remove contact lenses if present, consult a physician
Ingestion: Rinse mouth, drink water in small amounts, never give anything by mouth to an unconscious person, seek medical help without delay
Other Notes: Provide this sheet to medical responders, treat symptomatically, monitor for delayed effects
Suitable Extinguishing Agents: Use water spray, foam, dry chemical powder, or carbon dioxide
Specific Hazards: Vapors or combustion products may be toxic, including nitrogen oxides and carbon oxides
Special Firefighting Procedures: Wear self-contained breathing apparatus, protective gear, cool fire-exposed containers with water
Explosion Limits: Dust may form explosive mixture with air under certain conditions
Advice for Firefighters: Move containers from fire area if it can be done without risk, avoid inhaling combustion products
Personal Precautions: Evacuate area, ventilate space, wear NIOSH-approved respirator and full protective clothing
Environmental Precautions: Prevent leakage or additional spillage, contain run-off to avoid entry into drains or soil
Spill/Cleanup Procedure: Sweep up material using non-sparking tools, avoid raising dust, collect in container for disposal, rinse area with water after removal
Decontamination: Wash spill site after material removal, dispose of cleaning rags or equipment in a chemical waste container
Reporting: Notify proper authorities as required by local regulations if spillage enters environment
Handling: Avoid direct contact or inhalation, use only in well-ventilated areas or fume hood, wear suitable protective clothing, keep container tightly closed
Hygiene Measures: Do not eat, drink, or smoke while using this chemical, wash thoroughly before breaks and after use
Storage: Keep away from strong oxidizers, heat, and ignition sources, store in a cool, dry, well-ventilated place away from sunlight
Incompatible Materials: Strong bases, acids, oxidizing agents, as well as reducing agents
Storage Classifications: Store with hazardous organic solids, segregate from foodstuffs
Exposure Limits: No specific ACGIH or OSHA limits, but minimize exposure as much as possible
Eye Protection: Safety goggles meeting ANSI Z87.1 or equivalent
Hand Protection: Nitrile or neoprene gloves resistant to organic chemicals
Respiratory Protection: Approved dust/fume respirators if ventilation is inadequate
Other Protective Gear: Lab coat, protective apron, closed-toe shoes
Engineering Controls: Use fume hoods, local exhaust ventilation, ensure eyewash and safety showers are accessible
Appearance: Pale yellow crystalline powder
Odor: Slight characteristic odor
Melting Point: 80–82°C
Boiling Point: 306°C
Solubility: Slightly soluble in water, soluble in ethanol and ether
Vapor Pressure: Negligible at ambient temperature
Density: 1.26 g/cm³ at room temperature
pH: Not applicable as a solid
Partition Coefficient: log Kow approximately 1.92
Evaporation Rate: Not volatile under standard conditions
Chemical Stability: Stable under normal laboratory and storage conditions
Conditions to Avoid: Excessively high temperatures, direct sunlight, ignition sources, open flames
Hazardous Reactions: May react strongly with oxidizers and reducing agents
Decomposition Products: Hazardous gases like nitrogen oxides, carbon monoxide, carbon dioxide under fire conditions
Polymerization Risk: Will not occur under normal circumstances, though avoid storage near incompatible substances
Acute Toxic Effects: Harmful if swallowed, moderate skin and eye irritant, inhalation may cause respiratory irritation, headaches, dizziness
Chronic Toxicity: Prolonged exposure can lead to organ effects, mainly on liver and kidneys, due to accumulation or metabolic impact
LD50 Values: Oral rat LD50 approximately 400 mg/kg
Carcinogenicity: Unclassified by major agencies, ongoing studies regarding long-term exposure
Mutagenicity: Some evidence in in-vitro models but not fully conclusive on humans
Target Organs: Liver, kidneys, central nervous system
Additional Info: No evidence of skin sensitization in current literature, always handle using appropriate protection given uncertainties
Aquatic Toxicity: Harmful to aquatic life, potential for long-term adverse effects in aquatic environments
Persistence: Degrades slowly in water, subject to biotransformation over weeks to months
Bioaccumulation: Moderate potential based on log Kow, may concentrate in organisms
Mobility: Tends to bind to soil particles at neutral to acidic pH, may leach through sandy soils if water is present
Environmental Precautions: Avoid release into the environment, restrict discharge to sewers, soil or surface water
Waste Treatment Methods: Collect and seal in labeled hazardous waste containers for disposal
Disposal of Packaging: Triple rinse and puncture containers before disposal or recycling where permitted, follow local chemical waste guidelines
Incineration: High-temperature incineration in an approved facility reduces environmental risk
Do Not Dispose: Avoid disposing down drain, landfill, or regular municipal waste
Local Regulations: Adhere to national, state, and local hazardous waste regulations
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 4-Nitroanisole)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III (lower risk, but still hazardous)
Label Required: Toxic Substance (skull and crossbones symbol)
Special Transport Precautions: Secure containers during transport, carry spill kit, follow handling guidelines for toxic organics
Environmental Hazards: Dangerous to the environment with accidental spills during transport
OSHA: Substance included in hazardous chemical inventory, covered by Hazard Communication Standard
TSCA: Listed on Toxic Substances Control Act inventory in the United States
EINECS: Listed in European catalog of existing commercial chemical substances
REACH: Subject to restrictions on manufacture, marketing, and use in the European Union
SARA Title III: Not listed as an extremely hazardous substance, but reportable due to toxicity classification
International Regulations: Transported under IATA and IMDG safety codes as a regulated toxic substance
Workplace Labelling: Ensure prominent warning and handling instructions are posted in storage and handling areas
