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Chemical Name: 4-Nitro-2-Toluidine
Synonyms: 2-Methyl-4-nitroaniline, p-Nitro-o-toluidine, C.I. 37500
CAS Number: 99-52-5
EC Number: 202-765-8
Recommended Use: Dye intermediate, analytical chemistry, pigment production
Manufacturer Details: Chemical supplier or production facility address, phone, emergency contact number provided on label
Emergency Contact: Refer to Chemtrec, local poison control, or emergency responder information
Hazard Classification: Acute Toxicity (Oral, Dermal, Inhalation), Eye Irritation, Skin Sensitization, Specific Target Organ Toxicity
Signal Word: Warning
Hazard Statements: Toxic if swallowed or inhaled; causes skin irritation; may cause allergic skin and respiratory reactions; suspected of damaging fertility or the unborn child; possible risk of cancer
Pictograms: Skull and crossbones, exclamation mark, health hazard symbol
Precautionary Statements: Wear protective gloves and safety glasses, avoid breathing dust, do not eat or drink in work area, wash thoroughly after handling, keep container tightly closed
Routes of Exposure: Ingestion, inhalation, skin contact, eye contact
Chemical Identity: 4-Nitro-2-Toluidine
CAS No.: 99-52-5
Concentration: Typically >99% (may contain trace impurities or other aromatic amines dependent on process source)
Inhalation: Remove person to fresh air immediately, monitor for breathing difficulty, give oxygen if available, seek urgent medical attention
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for 15 minutes, use soap, seek medical advice if irritation persists
Eye Contact: Rinse eyes slowly and gently with water for at least 15 minutes, keep eyelids open, remove contact lenses if present, get immediate medical help
Ingestion: Rinse mouth with water, never induce vomiting, monitor for breathing or neurological symptoms, seek immediate healthcare assistance
Most Important Symptoms: Headache, confusion, dizziness, cyanosis, respiratory distress, skin sensitization, and allergic reactions
Notes for Doctor: Treat symptomatically, be aware of possible methemoglobinemia, administer oxygen and consider methylene blue treatment if cyanosis occurs
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Unsuitable Extinguishing Media: Do not use water jets directly on burning substance
Special Hazards: Emits toxic fumes (nitrogen oxides, carbon monoxide, aniline vapors) when heated or combusted
Advice for Firefighters: Wear full protective gear including self-contained breathing apparatus, avoid inhaling combustion products, prevent runoff water from entering waterways
Explosion Sensitivity: Does not pose unusual risk of explosion under normal conditions but can form combustible dust-air mixtures
Other Information: Evacuate area if necessary, use fire-resistant barriers
Personal Precautions: Wear gloves, chemical goggles, particulate respirator, and protective clothing to prevent skin and eye contact
Environmental Precautions: Prevent spillage from entering sewers, drains, or waterways; restrict access to site
Containment Methods: Confine spillage using sand, earth, or inert absorbent material, collect and store in properly labeled hazardous waste containers
Clean-up Method: Sweep up carefully to avoid dispersal of dust, decontaminate surface with water and detergent, ventilate area
Disposal: Place contaminated material in sealed drums for subsequent incineration
Safe Handling: Work in well-ventilated areas or use fume hood, avoid generation and inhalation of dust, minimize skin and eye exposure, do not ingest, avoid contact with incompatible materials (strong oxidizers, reducing agents), do not eat, drink, or smoke in work area
Storage Conditions: Store in tightly sealed containers in cool, dry, well-ventilated place away from heat, sunlight, and sources of ignition
Incompatible Materials: Chlorinating agents, strong acids, alkalis, oxidizers, reducers
Other Precautions: Wash hands and face before breaks and at end of shift, label all containers properly, keep away from food and animal feed
Occupational Exposure Limits: Consult local regulations; suggested limit for similar aromatic amines is 0.1 mg/m³ (time-weighted average)
Engineering Controls: Use ventilation systems, fume hoods, and process enclosures to control airborne exposure
Personal Protection: Wear chemical-resistant gloves (such as nitrile or neoprene), splash-proof goggles, flame-resistant lab coat or disposable coveralls, dust mask or NIOSH-approved respirator (if dust or vapors are present)
Hygiene Measures: Remove contaminated clothing and protective equipment prior to leaving work area, avoid touching face, keep eyewash station and safety shower nearby
Appearance: Pale yellow to brown crystalline powder
Odor: Slightly aromatic
pH: Not determined for solid
Melting Point: 115 to 120°C
Boiling Point: Decomposes before boiling
Flash Point: Over 200°C (closed cup)
Evaporation Rate: Not applicable
Vapor Pressure: Negligible at standard temperature
Relative Density: About 1.3 g/cm³
Solubility: Poorly soluble in water, soluble in organic solvents (acetone, ethanol)
Partition Coefficient (log Kow): Estimated between 1.5 and 2.5
Auto-Ignition Temperature: Not readily self-igniting
Decomposition Temperature: At elevated temperatures forms toxic gases
Other Information: Stable under standard conditions, dust may form explosive mixtures with air
Chemical Stability: Stable under recommended storage conditions
Reactivity: May react with strong oxidizers, acids or alkalis leading to hazardous products
Conditions to Avoid: Excessive heat, direct sunlight, sparks, open flames, sources of ignition, strong acids and bases
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, aniline derivatives, unidentified organic compounds
Polymerization: Not known to occur under normal use
Storage Cautions: Keep containers closed, labeled, and away from incompatible materials
Acute Toxicity: Ingestion or inhalation causes headache, dizziness, cyanosis, risk of methemoglobinemia, and potential death at sufficiently high doses
Chronic Effects: Prolonged exposure may trigger allergic skin reactions or asthma, liver or kidney effects, possible carcinogenic or mutagenic effects noted in animal studies
Skin Contact: Causes irritation, possible sensitization on repeated contact
Eye Contact: Irritating, may cause reddening, watering, pain, blurred vision
Inhalation: Coughing, shortness of breath, cyanosis, chest tightness
Sensitization: Can induce allergic response with signs of dermatitis on repeated exposure
Other Effects: Investigated for blood disorders, especially methemoglobinemia; considered hazardous to reproductive health based on animal data
Aquatic Toxicity: Harmful to aquatic life with long-lasting effects, data for similar aromatic amines show acute LC50 values in fish and invertebrates below 10 mg/L
Persistence and Degradability: Not readily biodegradable, tends to persist in soil and sediment
Bioaccumulative Potential: Moderate based on log Kow, potential for bioaccumulation in organisms
Mobility in Soil: Expected to bind to soil particles and organic matter, limited migration in groundwater
Other Environmental Effects: Toxicity to microorganisms noted in laboratory studies, disrupts metabolic processes in algae and aquatic flora
Waste Disposal Method: Send for incineration by licensed hazardous waste contractor, never dispose in regular trash, sewage, or unprotected landfills
Container Disposal: Thoroughly rinse and neutralize empty containers before recycling or disposal, comply with local Enviromental Protection requirements
Precautions: Avoid breathing dust during handling of waste, use suitable PPE, label wastes clearly
Regulatory Notes: Subject to hazardous waste rules under RCRA in the US, similar frameworks elsewhere
UN Number: 1661
Proper Shipping Name: 2-Methyl-4-nitroaniline
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Transport Labels Required: Toxic substance label
Marine Pollutant: Not specifically regulated as marine pollutant, but evidence suggests it is harmful to aquatic environments
Special Transport Precautions: Secure packaging, avoid transport with food or animal feed, report accidental spills immediately based on local law
Classification: Regulated as a toxic or hazardous substance in Europe (REACH), the U.S. (OSHA, TSCA, CERCLA), Japan, Australia, and most other major jurisdictions
Hazard Symbols: T (Toxic), Xn (Harmful), N (Dangerous for environment)
Risk Phrases: Risk of serious damage to health by prolonged exposure, harmful if swallowed or inhaled, dangerous for the environment
Safety Phrases: Keep locked up, keep away from food and drink, ensure proper ventilation, wear suitable PPE
Inventory Status: Reported under EINECS/REACH, TSCA, and other chemical registries
Restrictions: Use may be limited for certain applications based on occupational safety or environmental guidelines
