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Product Name: 4-Nitro-2-Aminophenol
Chemical Formula: C6H6N2O3
Molecular Weight: 154.12 g/mol
SYNONYMS: 2-Amino-4-nitrophenol; p-Nitro-o-aminophenol
CAS Number: 99-57-0
Recommended Use: Laboratory chemicals, dyes intermediate
Manufacturer/Distributor: Refer to product packaging or supplier
Emergency Contact: Refer to safety poster or company policy
GHS Classification: Acute toxicity (oral, inhalation, dermal), Skin irritation, Eye irritation, Specific target organ toxicity
Labels: Toxic, Harmful, Irritant, Dangerous for the environment
Signal Word: Danger
Hazard Statements: Harmful if swallowed; Causes skin and serious eye irritation; May cause respiratory irritation; May cause allergic skin reaction; May cause drowsiness or dizziness
Pictograms: Exclamation mark, Health hazard, Environment
Precautionary Statements: Avoid inhalation and contact with skin, eyes; Wash hands thoroughly after handling; Wear protective gloves, clothing, and eye protection; Use only outdoors or in well-ventilated area; Store locked up; Avoid release to the environment
Chemical Name: 4-Nitro-2-Aminophenol
Concentration: ≥98% (w/w)
Impurities: Trace amounts of related nitroaniline and aminophenol isomers
EC Number: 202-758-5
Inhalation: Move the affected person to fresh air immediately; Keep at rest; Seek immediate medical advice
Skin Contact: Remove contaminated clothing; Wash skin thoroughly with soap and water for at least 15 minutes; Get medical attention
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes; Lift eyelids to allow thorough rinsing; Obtain medical assistance right away
Ingestion: Rinse mouth with water if the person is conscious; Do not induce vomiting; Call poison control or a physician
Most Important Symptoms: Irritation, redness, nausea, headache, respiratory discomfort, allergic response
Immediate Medical Attention: Required in all cases of symptoms or overexposure
Suitable Extinguishing Media: Use dry chemical, foam, or carbon dioxide; Water spray for cool surrounding area
Unsuitable Extinguishing Media: Direct water jet
Specific Hazards: Produces toxic fumes under fire conditions; May generate nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Special Procedures: Evacuate area and fight fire from safe distance; Prevent runoff from entering water sources; Use caution due to possible toxic vapors
Personal Precautions: Evacuate unnecessary personnel; Wear chemical-resistant gloves, goggles, and respirator
Environmental Precautions: Prevent entry into drains, waterways, and soil
Methods for Clean-up: Absorb spill with inert material such as sand or vermiculite; Place in a chemical waste container; Avoid generating dust; Ventilate the area; Clean the contaminated area with detergent and water
Handling: Use in a chemical fume hood; Wear appropriate personal protective equipment; Avoid breathing dust or vapors; Do not eat, drink or smoke while using this material; Wash hands thoroughly after handling
Storage: Store in tightly closed containers in a cool, dry, ventilated area; Keep away from incompatible substances such as strong oxidizers and reducing agents; Do not store near moisture or direct sunlight; Store locked up and properly labeled
Exposure Limits: No established OSHA/ACGIH limits; Minimize exposure at all times
Engineering Controls: Use local exhaust ventilation; Use safety shower and eye wash stations in work area
Personal Protection: Wear suitable gloves (nitrile or neoprene), chemical goggles, laboratory coat or apron, respirator for dust or vapor exposure
Hygiene Measures: Do not eat, drink, or smoke in handling area; Wash thoroughly after handling; Remove contaminated clothing and launder before reuse
Appearance: Light yellow to orange crystalline powder
Odor: Slight; Phenolic
Melting Point: 143–146°C
pH: N/A (not applicable for solids)
Solubility: Slightly soluble in water; soluble in alcohol, ether
Boiling Point: Decomposes
Flash Point: Not available
Vapor Pressure: Negligible
Specific Gravity: ~1.55
Partition Coefficient (log Kow): ~0.6
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Moisture, heat, light, incompatible chemicals
Incompatible Materials: Strong acids, strong bases, strong oxidizers, reducing agents
Hazardous Decomposition Products: Nitrogen oxides (NOx), carbon monoxide, carbon dioxide, phenolic compounds
Hazardous Polymerization: Will not occur under normal conditions
Routes of Exposure: Inhalation, ingestion, skin/eye contact
Acute Toxicity: Harmful if swallowed, inhaled, or absorbed through skin
LD50 (Oral, Rat): ~400 mg/kg
Symptoms: Irritation, dizziness, headache, nausea, skin sensitization
Chronic Exposure: Long-term exposure may result in blood disorders, liver or kidney effects
Sensitization: Possible skin sensitizer
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Mutagenicity and Reproductive Toxicity: Not enough data available
Toxicity to Aquatic Life: Harmful to aquatic organisms; Avoid environmental contamination
Persistence and Degradability: May not degrade rapidly in the environment
Bioaccumulative Potential: Low potential for bioaccumulation
Mobility in Soil: Likely limited due to low water solubility
Other Adverse Effects: May have long-term effects on aquatic environments
Waste Treatment Methods: Dispose of material in accordance with all local, regional, national, and international regulations
Disposal of Contaminated Packaging: Dispose of as unused material
Precautions: Do not dump into drains, soil, or waterways; Label wastes clearly; Use a licensed chemical disposal company
UN Number: 2811 (for toxic solids, organic, n.o.s.)
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (Contains 4-Nitro-2-Aminophenol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Harmful to aquatic environments
Special Precautions for User: Avoid contact, spills, and package damage; Transport in compliance with local and international rules
TSCA (USA): Listed
EINECS (EU): Listed
REACH Status: Registration may be required
Labelling under GHS/CLP: Required; conforms to hazard statements
SARA Title III (USA): Not considered an extremely hazardous substance
Hazard Symbols: Xn (Harmful), Xi (Irritant), N (Dangerous for environment)
Other Regulations: Refer to local, national, and international regulations for safe usage and disposal
