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Chemical Name: 4-Methoxy-4-methyl-2-pentanone
CAS Number: 108-12-7
Molecular Formula: C7H14O2
Synonyms: Methyl isoamyl ketone, MIPK
Appearance: Clear, colorless to slightly yellow liquid
Odor: Ether-like or fruity
GHS Classification: Flammable liquid, Category 3; Acute toxicity, Category 4 (oral, inhalation); Eye irritation, Category 2A
Pictograms: Flame, exclamation mark
Main Hazards: Vapor can irritate eyes and respiratory system. Flammable liquid and vapor—ignition from heat, sparks, open flames possible. High vapor concentrations can cause drowsiness or dizziness. Prolonged skin contact may cause dryness or cracking.
Target Organs: Eyes, skin, respiratory tract, central nervous system
Signal Word: Warning
Substance: 4-Methoxy-4-methyl-2-pentanone
Concentration: Typically ranges between 97%–100% purity for laboratory use
Impurities: Trace amounts of other pentanone derivatives possible, usually <1%
Eye Contact: Flush the eyes with water for at least 15 minutes, lifting eyelids to ensure thorough rinsing. Seek medical help if irritation persists.
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water. If irritation develops, get medical advice.
Inhalation: Move the affected person to fresh air. Restore breathing if needed. Medical attention recommended in case of persistent symptoms.
Ingestion: Rinse mouth, do not induce vomiting unless told by medical personnel. Seek medical attention immediately.
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Unsuitable Media: Avoid direct stream of water, may spread fire.
Hazardous Combustion Products: Forms carbon oxides (CO, CO2) under fire conditions.
Special Equipment: Use self-contained breathing apparatus and full protective gear.
Fire Hazards: Vapors may travel to ignition source, flash back can occur. Containers exposed to extreme heat may rupture.
Personal Precautions: Evacuate unnecessary people, ventilate the area. Wear protective gloves, goggles, and suitable respirator to avoid breathing vapors.
Environmental Precautions: Prevent run-off into drains, soil, or waterways. Alert environmental authorities where spill threatens environment.
Containment: Absorb spillage with inert material (sand, vermiculite). Collect into containers for disposal according to local regulations. Flush the spill area with water after collection.
Handling Guidance: Keep away from heat, sparks, open flames, and hot surfaces. Use only with adequate ventilation. Prevent build-up of static charge by grounding/bonding containers. Do not smoke, eat, or drink during use.
Storage Recommendations: Store in tightly closed containers in a cool, well-ventilated area, away from incompatible materials like strong oxidizers, acids, or bases. Protect from sunlight and sources of ignition.
Occupational Exposure Limits: Some regulatory bodies set exposure limits; OSHA and ACGIH recommend exposure to be kept as low as practical.
Engineering Controls: Use explosion-proof ventilation to minimize vapor accumulation. Local exhaust preferred.
Personal Protective Equipment: Chemical-resistant gloves, protective goggles, lab coat. NIOSH-approved respirator suggested if vapor levels can exceed limits. Wash hands thoroughly after handling.
Physical State: Liquid
Color: Colorless to pale yellow
Boiling Point: About 144°C
Flash Point: 41–47°C (closed cup)
Vapor Pressure: Moderate at room temperature
Solubility: Moderately soluble in water, miscible with organic solvents
Density: About 0.91 g/cm³ at 20°C
Odor Threshold: Distinct at low parts per million
Chemical Stability: Remains stable under standard conditions. Sensitive to moisture and acid catalysis over time.
Conditions to Avoid: Contact with ignition sources, heat, or direct sunlight accelerates degradation.
Incompatibility: Avoid strong oxidizers, acids, bases. Potential for violent reaction.
Hazardous Decomposition: Produces carbon monoxide and carbon dioxide under thermal decomposition.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: Inhalation can cause headache, drowsiness, or respiratory irritation. Oral exposure can result in nausea and gastrointestinal issues. Skin contact may cause dryness.
Chronic Effects: Long-term exposure at high concentrations can affect liver and kidneys.
Irritation and Sensitization: Eye and respiratory tract irritant. Not known as a skin sensitizer based on available studies.
Carcinogenicity: Not listed as a known carcinogen by NTP, IARC, or OSHA.
Aquatic Toxicity: Moderately toxic to aquatic organisms at high concentrations. Significant spills should be contained to limit environmental damage.
Persistence and Degradability: Expected to degrade in the environment; volatile and subject to photodegradation.
Bioaccumulation Potential: Low likelihood based on molecular structure. Not expected to persist in food chains.
Waste Handling: Use a licensed chemical waste disposal company. Consult local, regional, and national authorities for environmental compliance.
Contaminated Packaging: Empty containers should be rinsed thoroughly, then disposed as hazardous chemical waste.
Incineration: Suitable for high-temperature incineration in approved facilities.
UN Number: 1262
Proper Shipping Name: Pentanones, liquid
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Transport Labels: Flammable Liquid
Precautions: Ensure container integrity and labeling. Segregate during storage and transport from incompatible substances.
GHS Labeling: Follows international standards on hazard communication.
SARA Title III: 4-Methoxy-4-methyl-2-pentanone may be subject to reporting requirements under certain usage or storage conditions in the United States.
TSCA: Present in the Toxic Substances Control Act inventory. Most uses permitted, but compliance with relevant workplace safety protocols applies.
REACH (Europe): Registration and safety data required for larger volumes. Restrictions on discharges to the environment in EU member states.
Workplace Requirements: U.S. OSHA Hazard Communication Standard requires hazard information provision and training for workers.
