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Product Name: 4-Ethoxyaniline
Synonyms: p-Ethoxyaniline, p-Aminophenetole
Chemical Formula: C8H11NO
Molecular Weight: 137.18 g/mol
CAS Number: 156-43-4
Recommended Use: Laboratory chemicals, research and development, organic synthesis
Supplier: Chemical supply companies that carry laboratory reagents (specific details available on purchase documentation)
Emergency Contact: Refer to local, federal, and institutional emergency protocols; typically handled through the institution's Environmental Health and Safety office or local poison control
GHS Classification: Acute toxicity (oral, dermal, inhalation, category 4); Skin irritation (category 2); Eye irritation (category 2A); Sensitization (category 1)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, in contact with skin, or if inhaled; Causes skin and eye irritation; May cause allergic skin reaction
Precautionary Statements: Avoid breathing dust, fumes, gas, mist, vapors, spray; Wash thoroughly after handling; Wear protective gloves, clothing, eye and face protection; If on skin, wash with plenty of water; If in eyes, rinse cautiously with water for several minutes
Health Effects: Can cause headaches, dizziness, vomiting, methemoglobinemia, hemolytic anemia with repeated exposure
Chemical: 4-Ethoxyaniline
CAS Number: 156-43-4
Concentration: 98-100%, depending on supplier; impurities may include related aromatic amines in trace amounts
Impurities: Residual solvents, alternative positional isomers, typically below 1%
General Advice: Move affected person away from exposure; seek immediate medical attention
If Inhaled: Remove to fresh air, monitor breathing, administer oxygen if breathing becomes difficult, consult a physician
If on Skin: Wash with soap and water for at least 15 minutes, remove contaminated clothing, consult a physician
If in Eyes: Rinse cautiously for several minutes with water, remove contact lenses if present, get medical attention
If Swallowed: Rinse mouth, do not induce vomiting without advice from medical professional, call poison control
Most Important Effects: Irritation, cyanosis (bluish color from lack of oxygen), confusion, labored breathing may develop
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, water spray
Unsuitable Media: Direct water jets can spread the material
Fire Hazards: Emits toxic fumes including nitrogen oxides, carbon monoxide, carbon dioxide on combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus with full protective gear
Special Procedures: Remove containers from affected area if safe; stay upwind; avoid inhalation of decomposition gases
Explosion Risk: Not classified as explosive; dust may form combustible mixtures with air
Personal Precautions: Wear appropriate PPE, avoid dust formation, ventilate area
Environmental Precautions: Prevent spillage from entering sewers, surface or groundwater; report relevant releases to proper authorities
Cleanup Methods: Sweep or absorb material in inert absorbent (vermiculite, sand); transfer to container for disposal
Decontamination: Wash area thoroughly with soap and water after removal
Disposal: Dispose as hazardous waste under local regulations; do not flush into drains
Handling: Avoid contact with skin, eyes, and clothing; use only with adequate ventilation; handle using chemical fume hood if possible
Storage Conditions: Keep container tightly closed in cool, dry, well-ventilated area; store away from food, incompatible substances, heat sources
Incompatibilities: Strong oxidizers, acids, acid chlorides, acid anhydrides; avoid contact with bases and reducing agents
Hygiene Measures: Wash hands and face before breaks, after work; keep contaminated clothing separate
Engineering Controls: Use local exhaust ventilation, chemical fume hood, or appropriate system to control airborne levels
Exposure Limits: OSHA, NIOSH, and ACGIH have not established exposure limits for 4-ethoxyaniline; handle using best industrial hygiene practices
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, laboratory coat, appropriate respiratory protection if vapor/aerosol risk
Environmental Controls: Enclose operations, use spill protection to prevent environmental contamination
Hand Protection: Nitrile or neoprene gloves recommended
Eye / Face Protection: Splash-proof safety goggles, face shield for high-volume operations
Appearance: Pale yellow to orange crystalline solid or powder
Odor: Slight aromatic amine odor
Melting Point: 54-57°C
Boiling Point: 254-256°C
Solubility: Slightly soluble in water, soluble in organic solvents like ethanol, diethyl ether
Vapor Pressure: Low (not easily volatilized at room temperature)
Density: Approximately 1.08 g/cm³
pH: Not applicable (solid form)
Flash Point: 136°C (closed-cup)
Auto-Ignition Temperature: Not readily available
Partition Coefficient: log Kow estimated at 1.7
Evaporation Rate: Not significant
Chemical Stability: Stable under recommended storage conditions
Incompatible Materials: Strong oxidizing agents, acid chlorides, acid anhydrides, bases, strong reducing agents
Conditions to Avoid: Extreme heat, moisture, sources of ignition, incompatible chemicals
Hazardous Decomposition: Nitrogen oxides, carbon monoxide, carbon dioxide
Possibility of Hazardous Reactions: Can react with oxidizers to release toxic gas
Acute Toxicity: Oral LD50 (rat): 388 mg/kg; dermal and inhalation LD50 values not thoroughly studied but considered hazardous
Skin / Eye Contact: Moderate to severe irritation possible; may cause allergic reactions
Inhalation: May cause respiratory tract irritation, dizziness, shortness of breath, methemoglobinemia
Ingestion: Headaches, nausea, vomiting, cyanosis, drowsiness; repeated ingestion impacts blood and liver
Chronic Effects: Repeated exposure can damage blood (hemolysis, anemia), potential bladder toxicity as with related aromatic amines
Carcinogenicity: Not classified by IARC; related aromatic amines linked to cancer—handle with caution
Sensitization: May cause allergic skin reaction in sensitized individuals
Other Information: No data available on reproductive or developmental toxicity
Aquatic Toxicity: Harmful to aquatic life with long-lasting effects; LC50 (fish) and EC50 (daphnia) can be low for similar compounds
Persistence and Degradability: Expected to be partly biodegradable; aromatic structure resists rapid breakdown
Bioaccumulative Potential: Low potential estimated based on log Kow; more data required
Mobility in Soil: May leach through soil in significant spills; poorly soluble but persists due to low biodegradation rate
Other Hazards: Toxic to aquatic microorganisms; avoid release to environment
Regulatory Reporting: Releases to water or land may need reporting to authorities
Waste Disposal Methods: Incinerate in approved facility; avoid landfill or sewer disposal
Container Disposal: Triple rinse, offer for recycling or reconditioning, puncture and dispose under environmentally responsible protocols
Local Regulations: Follow all local, state, and national hazardous waste laws
Contaminated Packaging: Handle as hazardous waste unless thoroughly decontaminated
UN Number: UN2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (4-Ethoxyaniline)
Transport Hazard Class(es): 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Harmful to water; marine pollutant labeling may apply
Special Precautions: Avoid breathing dust, secure container during transportation, follow DOT and IATA rules for hazardous materials
Labels Required: Toxic, consult logistics services for updates in classification
TSCA: Listed on the U.S. Toxic Substances Control Act (TSCA) inventory
SARA: May be subject to SARA Section 313 reporting as an environmental toxicant
REACH: Included on the European Inventory of Existing Commercial Chemical Substances; use restrictions may apply in specific zones
Workplace Safety: OSHA hazard communication standard applies; use appropriate Safety Data Sheet distribution and training
Other Regulations: Subject to inspection and reporting under Clean Water Act, Clean Air Act, Canadian WHMIS, and local chemical inventory lists
