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Chemical Name: 4-Chlorophenylhydrazine Hydrochloride
Synonyms: p-Chlorophenylhydrazine hydrochloride; 4-Chloro-1-phenylhydrazinium chloride
CAS Number: 40122-66-3
Recommended Uses: Laboratory reagent, intermediate for pharmaceutical synthesis
Supplier Details: Name, Address, Contact Number, Email for the distributor or manufacturer
Emergency Contact: 24-hour phone number for emergencies involving chemical exposure or spills
Classification: Acute toxicity (Oral, Dermal, Inhalation), Skin irritation, Eye irritation
GHS Label Elements: Warning pictogram, signal word “Danger”, hazard statements about toxicity and irritation
Hazard Statements: Harmful if swallowed, toxic in contact with skin, causes severe skin and eye irritation
Precautionary Statements: Avoid breathing dust or vapors, wash thoroughly after handling, wear protective gloves and eye protection
Chemical Identity: 4-Chlorophenylhydrazine Hydrochloride
Purity: ≥98%
Molecular Formula: C6H7Cl2N2
Molecular Weight: 195.05 g/mol
Other Components: No other hazardous components above threshold limits
Inhalation: Move exposed person to fresh air immediately. Loosen tight clothing. Seek medical advice if symptoms appear (coughing, shortness of breath, headache).
Eye Contact: Rinse with plenty of water for at least 15 minutes, lifting eyelids occasionally. Get medical attention, especially if irritation persists.
Skin Contact: Remove contaminated clothing and wash affected area thoroughly with soap and water. Get medical attention if skin irritation develops.
Ingestion: Rinse mouth with water—never give anything by mouth if the person is unconscious. Seek immediate medical attention.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, or water spray
Unsuitable Extinguishing Media: Strong water jets
Fire Hazards: Emits toxic fumes, including hydrochloric acid, chlorine, nitrogen oxides, and carbon monoxide in case of fire
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and protective clothing
Specific Procedures: Remove containers from fire area if safe to do so, cool containers with water spray to prevent pressure build-up and potential explosion
Personal Precautions: Use personal protective equipment such as gloves, goggles, lab coat, and suitable respiratory protection
Environmental Precautions: Prevent material from entering storm drains, waterways, or soil
Methods for Containment and Cleaning Up: Avoid creating dust. Sweep up spills with non-sparking tools, transfer to labelled container for disposal, ventilate affected area, clean residue with appropriate cleaning agents
Safe Handling: Avoid contact with skin, eyes, and clothing. Use only in well-ventilated areas or chemical fume hoods. Do not breathe dust or vapors. Wash hands thoroughly after handling.
Storage Requirements: Store tightly closed in a dry, cool, well-ventilated place away from sources of ignition, strong oxidizing agents, acids, and direct sunlight. Keep container firmly sealed, and restrict access to authorized personnel.
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Exposure Limits: No specific Occupational Exposure Limits established; handle using recommendations for irritants and toxic substances
Engineering Controls: Use local exhaust ventilation or process enclosures to keep airborne levels below recommended exposure levels
Personal Protection: Chemical-resistant gloves (nitrile recommended), goggles or face shield, lab coat or protective clothing, suitable respiratory protection for dust and fumes; ensure eyewash stations and safety showers are nearby
Hygiene Measures: Do not eat, drink, or smoke during use. Remove contaminated clothing and wash before reuse.
Appearance: Off-white to pale beige powder or crystalline solid
Odor: Faint, characteristic aromatic odor
pH: 3.0–4.0 (5% solution in water)
Melting Point/Range: 196–201°C
Boiling Point/Range: Decomposes before boiling
Solubility: Freely soluble in water; slightly soluble in ethanol
Vapor Pressure: Negligible at ambient temperature
Relative Density: Approximately 1.43 g/cm³
Flash Point: Not applicable (solid substance)
Partition Coefficient (n-octanol/water): Not available
Chemical Stability: Stable under normal temperatures and storage conditions
Conditions to Avoid: Moisture, heat, open flames, direct sunlight
Incompatible Materials: Strong oxidizers, acids, bases
Hazardous Decomposition Products: Hydrogen chloride gas, nitrogen oxides, and phosgene gas on thermal decomposition
Polymerization: Does not undergo hazardous polymerization under recommended conditions
Acute Toxicity: Harmful if swallowed, inhaled, or absorbed through skin; LD50 (oral, rat) approximately 200-300 mg/kg (literature values)
Skin Corrosion/Irritation: Causes skin irritation
Eye Damage/Irritation: Causes serious eye irritation
Respiratory Sensitization: Can irritate respiratory tract; may trigger coughing, throat irritation
Chronic Effects: Prolonged exposure can damage blood, liver, kidneys; mutagenic and carcinogenic effects not clearly established
Symptoms of Exposure: Nausea, headache, dizziness, allergic skin reactions, redness or pain at areas of contact
Aquatic Toxicity: Harmful to aquatic organisms; potential long-term adverse effects in aquatic environments
Persistence and Degradability: Not easily biodegradable; may accumulate in water and soil
Bioaccumulative Potential: Moderate potential based on structure and solubility
Mobility in Soil: May migrate through soil and accumulate; avoid discharge into the environment
Other Adverse Effects: No information about significant ozone depletion, global warming, or endocrine disruption
Product Disposal: Dispose of in accordance with local, regional, and national regulations; incineration in a chemical incinerator equipped with afterburner and scrubber preferred
Contaminated Packaging: Dispose of as hazardous waste; ensure containers are emptied and rinsed before disposal
Waste Codes: Follow local regulatory codes for hazardous chemical waste and laboratory waste streams
UN Number: UN2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 4-Chlorophenylhydrazine Hydrochloride)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III (substances with low acute toxicity)
Labels: Toxic
Special Precautions: Transport in original containers, avoid release to environment, keep away from foodstuffs and fire sources
OSHA Status: Regulated as a hazardous substance under OSHA standards in the workplace
TSCA Inventory: Listed
SARA Title III: Not listed under Sections 302, 304, 313; classified as hazardous under Section 311/312
RCRA Status: May be classified as hazardous waste upon disposal
International Regulations: Complies with European REACH regulations, EC Number 254-854-2; subject to strict handling guidelines in workplaces and transport under ADR/RID, IMDG, IATA regulations
