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Product Name: 4-Bromotoluene
Synonyms: p-Bromotoluene, 1-Bromo-4-methylbenzene
CAS Number: 106-38-7
Molecular Formula: C7H7Br
Molecular Weight: 171.04 g/mol
Supplier Details: Typical chemical suppliers provide name, address, and emergency contact information.
Use: Intermediate in organic synthesis, manufacturing of pharmaceuticals, agrochemicals, dyes.
Emergency Phone Number: Manufacturer’s emergency contact, typically on the product label.
GHS Classification: Flammable liquids (Category 4), Acute toxicity (Oral category 4), Skin irritation (Category 2), Eye irritation (Category 2A), Specific target organ toxicity – single exposure (Category 3)
GHS Label Elements: Signal word: Warning; Hazard statements: Flammable liquid and vapor, Harmful if swallowed, Causes skin and eye irritation, May cause respiratory irritation
Precautionary Statements: Keep container tightly closed, Avoid breathing dust or vapor, Use only outdoors or in well-ventilated area, Wear protective gloves/eye protection/face protection
Hazards Not Otherwise Classified: May cause allergic reaction in sensitive individuals, Combustion may release toxic gases such as hydrogen bromide and carbon monoxide.
Substance: 4-Bromotoluene
CAS Number: 106-38-7
Percentage: 99% or higher; impurities include trace amounts of toluene or other halogenated compounds depending on source
Impurities Contributing to Hazard: None identified in standard grade material.
Inhalation: Move to fresh air, give artificial respiration if not breathing, consult physician immediately.
Skin Contact: Remove contaminated clothing, flush skin with plenty of water and soap for at least 15 minutes, seek medical advice if irritation persists.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, get medical attention promptly if irritation persists.
Ingestion: Never give anything by mouth to an unconscious person, rinse mouth with water, seek medical advice immediately.
Self-Protection of First Aiders: Wear gloves and emergency respirators if available; minimize exposure to vapor or dust.
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide.
Specific Hazards: Flammable, may emit toxic fumes under fire conditions including hydrogen bromide, carbon oxides; vapors may travel and ignite remotely.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear.
Advice for Firefighters: Move containers from fire area if safe, cool exposed containers with water spray to prevent rupture; prevent run-off from entering drains or watercourses.
Personal Precautions: Avoid breathing vapors, ensure adequate ventilation, eliminate all ignition sources.
Protective Equipment: Gloves, goggles, lab coat or coveralls, approved respirator if needed
Emergency Procedures: Keep unnecessary personnel away, evacuate area if vapors are extensive.
Environmental Precautions: Prevent further leakage or spillage, do not let product enter drains, surface water, or soil.
Methods for Containment and Clean-up: Absorb spill with inert material (vermiculite, sand), collect in suitable container, dispose of according to local regulations; ventilate area and wash spill site after material pick-up is complete.
Precautions for Safe Handling: Avoid inhalation, ingestion, and contact with skin, eyes, or clothing; use only in well-ventilated areas with local exhaust ventilation.
Advice on General Occupational Hygiene: Change work clothes frequently, wash hands thoroughly before breaks and at end of work, do not eat or drink in substance-handling areas.
Conditions for Safe Storage: Store away from heat, sparks, open flames, and incompatible substances, such as strong oxidizers and acids; keep container tightly closed in a cool, dry, well-ventilated area, preferably in a flammable-chemicals cabinet with secondary containment.
Special Requirements: Use proper grounding and bonding practices to minimize static discharge risk.
Exposure Limits: No occupational exposure limit has been established by OSHA, ACGIH, or NIOSH for 4-Bromotoluene as of this writing.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits.
Personal Protection: Chemical-resistant gloves (such as nitrile or neoprene), safety goggles or face shield, flame retardant and impervious lab coat, chemical-resistant apron, use of NIOSH-approved respirator if exposure risk is significant.
Environmental Exposure Controls: Prevent contamination of soil, surface, and ground water; treat waste before discharge where required.
Appearance: Colorless to pale yellow liquid or crystalline solid
Odor: Faint aromatic smell
Odor Threshold: Not determined
pH: Not available
Melting Point: 27–30°C (approx.)
Boiling Point: 200–203°C
Flash Point: 82°C (closed cup, approximate)
Evaporation Rate: Not available
Flammability: Flammable
Upper/Lower Flammability Limits: Not available
Vapor Pressure: 0.18 mmHg @ 25°C
Vapor Density: 5.9 (air = 1)
Relative Density: 1.47 g/cm³ at 25°C
Solubility: Insoluble in water; soluble in organic solvents like ether, benzene, and ethanol
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not available
Decomposition Temperature: Not determined
Viscosity: Not available
Chemical Stability: Stable under ordinary conditions of storage and use
Possibility of Hazardous Reactions: Reacts with strong oxidizing agents; exothermic reaction possible with acids or alkali metals
Conditions to Avoid: Heat, flames, sources of ignition, static discharge, incompatible substances
Incompatible Materials: Strong acids, strong bases, oxidizers such as peroxides, nitric acid
Hazardous Decomposition Products: Bromine compounds, hydrogen bromide, carbon monoxide, carbon dioxide under fire conditions
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral LD50 (rat): 1,980 mg/kg; Inhalation LC50 and Dermal LD50 not well documented
Skin/Eye Irritation: Can cause moderate skin and eye irritation; redness, burning, itching reported
Respiratory Effects: High vapor concentrations may cause respiratory tract irritation, coughing, sore throat
Sensitization: Limited evidence for skin sensitization in humans
Chronic Effects: Long-term exposure data limited; repeated skin contact might cause dermatitis
Other Information: No data indicates carcinogenic, mutagenic, or reproductive hazards to humans for 4-Bromotoluene as of now
Ecotoxicity: Harmful to aquatic life; toxicity data for fish and daphnia is limited but expected to impact aquatic organisms negatively based on aromatic/halogenated structure
Persistence and Degradability: Not readily biodegradable in the environment; may persist for an extended period
Bioaccumulative Potential: Potential for bioaccumulation in aquatic organisms, based on estimated partition coefficient
Mobility in Soil: Low water solubility suggests low mobility; may adsorb strongly to organic matter in soil
Other Adverse Effects: Large spills can affect aquatic habitats and water quality; proper containment and clean-up are essential for minimizing environmental impact
Waste Treatment Methods: Incinerate in approved facility using appropriate technology for halogenated organics; small quantities can be absorbed onto suitable material and disposed of by chemical waste contractor
Disposal of Contaminated Packaging: Triple rinse and dispose drums or containers through licensed chemical waste handlers
Regulations: Dispose in compliance with federal, state, and local environmental control regulations
Precautions: Do not allow material to be released to the environment; collect and store waste in properly labeled containers with secure lids until disposal
UN Number: UN 2810 (for hazardous substances, depending on quantity and concentration)
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 4-Bromotoluene)
Transport Hazard Class: 6.1 (toxic substance, if applicable)
Packing Group: III (minor danger)
Environmental Hazards: Not regulated as marine pollutant, but avoid release to environment due to toxicity to aquatic organisms
Special Precautions for Users: Use proper shipping container, label appropriately, secure during transportation, ensure all handlers are trained in emergency procedures
US TSCA Inventory: Listed
Canada DSL/NDSL: Listed on DSL
EU EINECS/ELINCS List: Listed (203-398-6)
OSHA Hazards: Flammable liquid, irritant, toxic by ingestion
SARA Title III, Section 313: Not currently subject to reporting
California Proposition 65: Not listed as a known carcinogen or reproductive toxin
Other National/International Regulations: Comply with workplace safety, dangerous goods, and chemical substance regulations of relevant jurisdiction; consult local regulatory authorities for additional restrictions or requirements
