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Product Name: 4-Bromobenzoyl Chloride
Chemical Formula: C7H4BrClO
CAS Number: 99-60-5
Synonyms: p-Bromobenzoyl chloride, 4-Bromobenzoic acid chloride
Intended Use: Laboratory chemicals, synthesis of pharmaceuticals, specialty organic synthesis
Manufacturer/Supplier: Manufacturer name and details required on specific container
Emergency Contact: Emergency response team contact differs by region—include phone numbers and company-specific lines
Recommended Restrictions: Not for food, drug, or household purposes; not suitable for inexperienced handlers
Emergency Overview: Colorless or pale yellow liquid with sharp, pungent odor; strong lachrymator; reacts violently with water and alcohols
Classification: Corrosive to skin, eyes, respiratory tract; acute toxicity (oral, inhalation, dermal); harmful to aquatic life
Hazard Statements: Causes severe skin burns and eye damage; may cause respiratory irritation; harmful if inhaled, swallowed, or absorbed through skin
Signal Word: Danger
Precautionary Statements: Wear protective gloves, clothing, eye protection, face shield; avoid breathing vapors or mists; use only outdoors or in well-ventilated area; wash thoroughly after handling; do not eat, drink, or smoke near product
Physical Hazards: Emits toxic fumes (hydrogen chloride, bromides) during combustion
Environmental Hazards: Toxic to aquatic life with long lasting effects
Pictograms: Corrosive, Health Hazard, Environmental Hazard
Chemical Name: 4-Bromobenzoyl Chloride
Concentration: >98% by weight
Molecular Weight: 219.46 g/mol
Impurities and Stabilizing Additives: Trace amounts of related aromatic chlorides or bromides may be present due to synthesis
Inhalation: Move the person to fresh air immediately; monitor for respiratory distress; provide supplemental oxygen if available; consult physician rapidly for assessment and management; perform CPR if breathing stops
Skin Contact: Remove contaminated clothing and rinse exposed skin thoroughly under running water for at least 15 minutes; use mild soap if available; do not delay medical attention
Eye Contact: Flush eyes with plenty of water using eyewash station for at least 20 minutes, lifting eyelids frequently to ensure complete irrigation; urgent medical examination required
Ingestion: Rinse mouth thoroughly; do not induce vomiting; give moderate amount of water; seek emergency medical help; never give anything by mouth to an unconscious or convulsing person
Notes for Doctor: Treat symptomatically and supportively; monitor respiratory and cardiovascular function closely; chemical burns possible in gastrointestinal tract if ingested
Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, or foam; do not use water directly on substance as violent reaction will occur
Special Hazards: Releases toxic, corrosive gases (hydrogen chloride, bromine compounds) on combustion; reacts violently with water to form acidic mists
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective suit needed to prevent exposure to toxic vapors and splashes
Advice for Firefighters: Keep containers cool by spraying with water from as far away as possible to avoid contact; avoid all runoff and fire fighting water entering drains or watercourses due to high toxicity
Additional Information: Evacuate area; approach from upwind; chemical-resistant gloves and positive pressure respiratory equipment mandatory for all involved personnel
Personal Precautions: Wear chemical splash goggles, chemical-resistant gloves, coveralls, and face shield; prevent skin and eye contact; avoid inhalation of fumes
Environmental Precautions: Prevent entry into waterways, sewers, basements, or confined areas; contain spill with dikes or absorbent materials
Cleanup Methods: Absorb spilled liquid with inert material such as clay, dry sand, or vermiculite; scoop into suitable chemical waste container; neutralize residue with dilute sodium bicarbonate or lime solution; ventilate area thoroughly after cleanup; dispose in accordance with local regulations
Emergency Procedures: Evacuate and restrict access to affected area; notify immediate supervisor and environmental agency if release is significant; decontaminate surfaces thoroughly to avoid delayed exposure
Handling: Always use in a chemical fume hood or well-ventilated area; avoid contact with skin, eyes, and clothing; do not breathe vapors; keep container closed tightly except when removing chemical; employ non-sparking tools and proper grounding; prohibit eating, drinking, or smoking in work area; wash hands before breaking for meal or at shift change
Storage: Store under dry, cool, and well-ventilated conditions; keep tightly sealed in original labeled container; separate from strong bases, water, alcohols, oxidizing agents, and amines; designated chemical storage area with acid-resistant secondary containment required; keep away from direct sunlight and sources of ignition; protocols must be in place for periodic container inspection to check for leaks or corrosion
Engineering Controls: Local exhaust ventilation and general dilution ventilation recommended; chemical fume hood mandatory during use
Personal Protective Equipment: Nitrile or neoprene chemical-resistant gloves, impermeable apron, full face shield, chemical splash goggles; avoid areas with inadequate protection; respiratory protection (NIOSH-approved full-face air-purifying respirator with acid gas cartridge or supplied-air respirator) required in absence of adequate ventilation
Occupational Exposure Limits: No specific OSHA or ACGIH exposure limits; safe work practices and exposure monitoring are essential
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling; emergency safety shower and eye wash station within immediate access; launder contaminated clothing before reuse; maintain clean work zones free from incompatible materials
Appearance: Colorless to pale yellow liquid
Odor: Sharp, pungent lachrymator odor
Odor Threshold: Data unavailable, irritation perceptible at low concentrations
pH: Not applicable (hydrolyzes in water)
Melting Point: Approximately 10-15°C
Boiling Point: Approximately 253°C (with decomposition)
Flash Point: About 120°C
Evaporation Rate: Information not determined
Flammability: Not flammable under normal conditions, but combustible if exposed to high heat
Vapor Pressure: Low at room temperature
Vapor Density: Heavier than air
Relative Density: 1.613 g/cm³
Solubility: Reacts exothermically and violently with water
Partition Coefficient (n-octanol/water): Data not available
Decomposition Temperature: Decomposes to release corrosive fumes
Viscosity: Low, similar to other acyl chlorides
Chemical Stability: Unstable in presence of water and moist air, rapidly hydrolyzes to 4-bromobenzoic acid, hydrogen chloride
Reactivity: Vigorous reaction with water, alcohols, strong bases, amines; forms exothermic reaction products
Incompatible Materials: Strong oxidizing agents, ammonia, strong bases, alcohols, moisture, acids different from intended use
Hazardous Decomposition Products: Hydrogen chloride, bromine, benzoic acid derivatives
Polymerization: Not expected under normal storage and handling, but decomposition can occur with time or at elevated temperatures
Conditions to Avoid: High humidity, direct heat, contact with strong oxidizers or bases, accidental mixture with water
Acute Toxicity: Harmful acute effects through oral, dermal, and inhalation exposure; LD50 values for rats (oral) approximately 750 mg/kg; no reliable LD50 for inhalation or dermal due to likelihood of corrosive injury
Skin Corrosion/Irritation: Severe burns result from direct contact; delayed symptoms possible
Serious Eye Damage/Irritation: Permanent eye damage or blindness risk from splashes
Respiratory Sensitization: Strong irritant effect on respiratory tract; prolonged exposure can lead to chemical pneumonitis
Skin Sensitization: No data for allergic response, but rapid corrosive action dominates
Chronic Effects: No published data on long-term health effects of low-level exposure; main risk comes from acute injury and improper decontamination
Mutagenicity, Carcinogenicity, Reproductive Toxicity: No extensive studies available; use utmost caution and limit exposure
Environmental Fate: Hydrolyzes rapidly on contact with moisture into 4-bromobenzoic acid and hydrogen chloride; highly mobile in water, potential to acidify soil and surface water
Persistence and Degradability: Degradation products persist in soil and water, changing local pH
Bioaccumulation: Low potential based on chemical structure, but environmental monitoring should be performed
Aquatic Toxicity: Severe toxic effects toward aquatic organisms reported; EC50 data for Daphnia magna in low mg/L range
Other Adverse Effects: Contributes to acidification and salinization of exposed habitats; toxicity to terrestrial mammals untested, but risk assumed based on corrosive mechanism
Waste Disposal Methods: Collect waste in tightly closed, labeled containers; neutralize unreacted material with dilute sodium bicarbonate or sodium carbonate solution in a fume hood; treat resulting mixture as hazardous; secondary treatment with absorbent material prior to landfill or incineration by licensed chemical waste contractor
Container Disposal: Triple-rinse containers with compatible solvents; perforate and dispose of as hazardous waste; do not attempt burning of any part of waste on site
Regulatory Requirements: Comply with all local, state, and federal environmental control laws—including RCRA for hazardous waste management and CERCLA for spill reporting above threshold
UN Number: UN 3265
UN Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains 4-Bromobenzoyl chloride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II (medium danger)
Label: Corrosive
Special Precautions: Transport in tightly closed, corrosion-proof containers; segregate from incompatible substances; vehicle signage showing Corrosive warning; notify authorities in case of substantial releases in transit; use trained personnel for loading/unloading
Marine Pollutant: Yes, due to aquatic toxicity risk
Additional Information: Subject to IMDG, IATA, and ADR transport safety codes; emergency transport documents required for international shipping
Labeling: Complies with OSHA Hazard Communication Standard; labeled as corrosive, toxic, and hazardous to the environment
Chemical Inventory Status: Listed on TSCA, EINECS, and other international inventories; subject to SARA Title III, Section 313 for reporting and tracking; included under REACH for manufacturers/importers in Europe
Workplace Safety Laws: Regulated under OSHA (US), WHMIS (Canada), and GHS worldwide for workplace exposure; requires employee training and documented risk assessment
Restrictions: Not for use in consumer products; research, industry, and specialty synthesis settings only
Other Requirements: Emergency response plans, spill kits, and chemical hygiene plans must be present in all work areas; containers require conspicuous hazard labels and emergency contact details; environmental release thresholds subject to local regulations
