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Product Name: 4-Bromoaniline
Chemical Formula: C6H6BrN
Synonyms: p-Bromoaniline, 1-Bromo-4-aminobenzene
CAS Number: 106-40-1
Recommended Use: Chemical research, industrial synthesis, pharmaceutical intermediate
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Classification: Acute toxicity (oral, dermal, inhalation); Skin and eye irritation; Harmful to aquatic life
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled; Causes skin and eye irritation; May cause liver and kidney damage; Toxic to aquatic organisms
Pictograms: Exclamation mark, environment
Precautionary Statements: Avoid breathing dust, fumes, gas, mist, vapor, or spray; Wash skin thoroughly after handling; Do not eat, drink, or smoke when using this product; Wear protective gloves, clothing, and eye protection; Avoid release to the environment
Chemical Name: 4-Bromoaniline
Common Name: p-Bromoaniline
CAS Number: 106-40-1
Concentration: Greater than 98% as pure chemical
Impurities: Potential traces of unreacted aniline, bromobenzene, or other related substituted anilines depending on the synthetic route
Inhalation: Move person to fresh air; Seek medical advice if symptoms persist; Provide artificial respiration if breathing difficult
Skin Contact: Remove contaminated clothing; Rinse skin with copious amounts of water; Seek medical attention if irritation develops
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lifting upper and lower eyelids; Remove contact lenses if present and easy to do; Get medical attention
Ingestion: Rinse mouth; Do not induce vomiting unless directed by medical personnel; Call poison control or seek immediate medical attention
Most Important Symptoms: Burning sensation, shortness of breath, allergic reactions, gastrointestinal disturbances
Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Special Hazards: Thermal decomposition releases toxic gases like nitrogen oxides, hydrogen bromide, carbon monoxide
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing; Stay upwind of fire; Avoid runoff to sewers and waterways
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen bromide
Personal Precautions: Ventilate area of spill; Avoid breathing vapor, dust, or mist; Prevent skin and eye contact by wearing intact gloves, safety goggles, and lab coat
Environmental Precautions: Prevent entry into sewers, drains, and waterways; Use absorbent materials to contain spills
Methods for Clean-Up: Sweep up using tools that minimize dust generation; Place into a suitable container for disposal; Ventilate affected area and wash spill site thoroughly after material pickup is complete
Handling: Avoid contact with skin, eyes, and clothing; Use in chemical fume hood to manage exposure; Do not breathe dust or vapor; Practice good industrial hygiene, including washing hands before breaks and at the end of the workday
Storage: Keep container tightly closed in a cool, dry, and well-ventilated area; Protect from moisture and direct sunlight; Store away from incompatible substances such as strong oxidizing agents and acids; Use only containers compatible with this material
Engineering Controls: Work in a fume hood with adequate ventilation; Install eyewash stations and safety showers nearby
Personal Protection: Wear chemical splash goggles, gloves of compatible material (nitrile or neoprene recommended), and long-sleeved lab coat or apron; Use respiratory protection if exposure limits are exceeded or risk assessment calls for it
Exposure Limits: No occupational exposure limits established specifically for 4-Bromoaniline, but handle as a hazardous material with care
Appearance: Pale to light tan solid, crystalline powder
Odor: Characteristic, amine-like
Odor Threshold: Not available
Melting Point: 63–67°C
Boiling Point: 265°C
Solubility: Slightly soluble in water, readily soluble in ethanol, chloroform, ether
Vapor Pressure: Very low at room temperature
Density: 1.617 g/cm³
pH: Slightly basic solution in water
Flash Point: Greater than 110°C (closed cup)
Partition Coefficient (log Kow): 1.99
Auto-Ignition Temperature: Data not available
Chemical Stability: Stable under recommended storage and handling; Slow degradation in light or air exposure
Reactivity: Not highly reactive under normal use
Incompatible Materials: Strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates
Hazardous Decomposition Products: Thermal degradation generates toxic vapors including bromine-containing compounds, nitrogen oxides
Polymerization: No evidence of hazardous polymerization under normal conditions
Routes of Exposure: Inhalation, skin, eye, ingestion
Acute Toxicity: Oral LD50 (rat): 500–1000 mg/kg; Skin and respiratory irritation observed in animal studies
Chronic Effects: Overexposure may affect the blood, liver, and kidneys; Prolonged exposure may lead to methemoglobinemia
Symptoms of Overexposure: Headache, dizziness, nausea, shortness of breath, possible cyanosis due to methemoglobin formation
Carcinogenicity: Not listed by NTP, IARC, or OSHA as a carcinogen
Mutagenicity: Limited evidence from animal studies; use with extra caution
Aquatic Toxicity: Toxic to aquatic organisms; May cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Poorly biodegradable; May persist in water and soil
Bioaccumulation: Potential for bioaccumulation in aquatic species, log Kow suggests moderate mobility
Other Adverse Effects: Harmful impact on fish and invertebrates; Runoff should be controlled to prevent environmental contamination
Waste Treatment: Dispose as hazardous waste with adherence to local, state, and federal regulations; Do not pour down drain
Waste Handling: Collect in sealed, clearly labeled containers for chemical waste; Avoid dust generation during transfer
Contaminated Packaging: Containers should be triple-rinsed and then disposed through hazardous waste service; Incineration recommended for all contaminated materials
UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 4-Bromoaniline)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Special Precautions: Avoid release to the environment during transportation; Secure tightly; Consult relevant carrier for full requirements
Environmental Hazards: Marine pollutant
TSCA Status: Listed
EINECS Number: 203-395-4
SARA Title III: Sections 302/304 (Not regulated), 313 (Reportable, listed as aniline derivatives)
OSHA: Hazardous under definition of Hazard Communication Standard
WHMIS Classification: D1B (Toxic), D2B (Other Toxic Effects)
Other Regulations: Subject to local, state, and international regulations for production, handling, and disposal
