© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Chemical Name: 4-Aminophenol Hydrochloride
Synonyms: p-Aminophenol hydrochloride, para-Aminophenol HCl
CAS Number: 51-78-5
Molecular Formula: C6H8ClNO
Manufacturer: See supplier label or purchase documentation
Recommended Use: Laboratory reagent, pharmaceutical intermediate, dye manufacturing, photographic developer
Supplier Contact Information: Refer to purchase records for address, emergency phone line, hours of operation, and designated contact persons for workplace and transportation incidents
GHS Classification: Acute Toxicity (Oral) Category 4; Skin Irritation Category 2; Eye Irritation Category 2A; Specific Target Organ Toxicity (Repeated Exposure) Category 2
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: Harmful if swallowed or in contact with skin, causes skin and eye irritation, may cause damage to organs through prolonged or repeated exposure (liver, kidneys)
Precautionary Statements: Avoid breathing dust, wear protective gloves and eye protection, wash hands thoroughly after handling, do not eat or drink while using, seek medical advice in case of discomfort
Potential Health Effects: Irritation of mucous membranes and skin, possible allergic reactions, hemolytic anemia may develop with chronic exposure
Special Labeling: Store away from food, keep out of reach of children, only trained personnel to handle
Component: 4-Aminophenol Hydrochloride
Chemical Percent: ≥ 98%
CAS Number: 51-78-5
Impurities: No significant impurities impacting classification
Additives: None reported by standard suppliers for analytical or bulk laboratory grades
General: Remove from exposure area as soon as possible, seek immediate medical attention in all cases
Inhalation: Move to fresh air, monitor for respiratory distress, administer oxygen if needed, contact poison center
Skin Contact: Remove contaminated clothing, rinse affected area under running water for at least 15 minutes, seek medical evaluation
Eye Contact: Rinse open eyes under running water for at least 15 minutes, lifting eyelids, continue irrigation while transporting victim to medical care
Ingestion: Rinse mouth with water, never induce vomiting without professional advice, seek emergency response
Advice to Doctors: Supportive measures, monitor for methemoglobinemia and kidney/liver impairment, treat symptomatically
Suitable Extinguishing Agents: Water spray, foam, dry chemical powder, carbon dioxide
Specific Hazards: Releases toxic fumes including ammonia, nitrogen oxides, hydrogen chloride under fire conditions
Protective Gear: Wear self-contained breathing apparatus, protective clothing to prevent contact with skin and eyes
Advice for Firefighters: Approach upwind, contain and collect contaminated fire water separately to prevent environmental release, fight fires remotely if material is powder-form in bulk
Explosion Risk: Dust clouds can ignite; implement grounding and bonding if transferring large quantities
Personal Precautions: Evacuate nonessential personnel, ensure adequate ventilation, fit gloves, goggles, dust mask or respirator
Environmental Protection: Prevent further leakage or spillage; avoid discharge into drains, surface or ground water; use measures to contain run-off
Methods for Clean-up: Absorb spilled substance with suitable inert material (sand, earth), sweep up and shovel into labeled waste containers, avoid raising dust, ventilate affected area
Special Procedures: Decontaminate surfaces using suitable cleaning agents, dispose of contaminated material according to section on waste disposal
Handling Practices: Avoid breathing dusts, prevent contact with skin and eyes, always handle in fume hood or well-ventilated area, use dedicated tools and containers
Hygiene Requirements: Wash hands, forearms and face thoroughly after handling, remove contaminated clothing and protective equipment before entering eating areas
Storage Conditions: Store in tightly sealed container, cool dry place, away from incompatible materials, segregate from strong oxidizers and acids, protect from direct light, label all containers with chemical identity and hazard warnings
Incompatible Materials: Strong acids, oxidizing reagents
Recommended Shelf Life: Follow expiration guidelines provided by supplier or based on chemical stability studies
Occupational Exposure Limits: No specific national occupational exposure limit established, keep airborne concentrations below nuisance dust limits (ACGIH TLV for particulates not otherwise regulated)
Engineering Controls: Local exhaust ventilation, process enclosures, eyewash stations, safety showers in immediate work area
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), safety goggles, face shield, disposable protective clothing or lab coat, dust mask (P2/P3) or respirator with appropriate cartridge
Environmental Controls: Handle in accordance with good industrial hygiene and safety practice, avoid release to environment by secondary containment methods
Appearance: White to off-white crystalline powder
Odor: Slightly aromatic
Odor Threshold: Not established
pH (1% solution): Approx. 3.5–5.5
Melting Point: 200–210°C (decomposes)
Boiling Point: Not available
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Non-flammable
Vapor Pressure: Negligible
Solubility in Water: Freely soluble
Partition Coefficient (n-octanol/water): Not determined
Vapor Density: Not applicable
Relative Density: ~1.4 g/cm³
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions, light-sensitive
Conditions to Avoid: High temperatures, exposure to strong light, contact with strong oxidizers, acid or base
Incompatible Materials: Oxidizing agents, acids, alkalies
Hazardous Decomposition Products: Nitrogen oxides (NOx), ammonia, hydrogen chloride fumes
Possibility of Hazardous Reactions: No dangerous reactions known under normal conditions
Polymerization: Does not polymerize
Acute Toxicity (Oral): LD50 (rat) ≈ 375 mg/kg
Acute Toxicity (Dermal): Data not fully established, expected to be harmful
Inhalation: Dust may irritate respiratory tract, can worsen asthma or chronic lung conditions
Skin Corrosion/Irritation: Causes irritation, redness
Serious Eye Damage/Irritation: Causes moderate eye injury or irritation
Respiratory Sensitization: Not established
Skin Sensitization: Possible sensitizer; repeated exposure may lead to dermatitis
Germ Cell Mutagenicity: Not classified based on available data
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: No conclusive evidence, animal data limited
Specific Target Organ Toxicity: Prolonged exposure may damage kidneys or liver
Aspiration Hazard: Not applicable (solid)
Toxicity to Aquatic Life: Hazardous in case of release to environment, toxic to fish and other aquatic organisms
Persistence and Degradability: Not readily biodegradable
Potential for Bioaccumulation: Low likelihood of significant bioaccumulation based on chemical structure
Mobility in Soil: Soluble in water, may migrate to groundwater
Other Hazards: Avoid uncontrolled releases, potential to cause long-term adverse effects in aquatic environment
Avoidance Measures: Store and use with spill prevention controls to limit exposure to water or soil
Waste Disposal Methods: Dispose of as hazardous waste in accordance with local, regional, and national regulations; incineration or chemical treatment may be appropriate
Contaminated Containers: Triple rinse, puncture and dispose of per hazardous waste standards, do not reuse
Sewage Disposal: Never pour into drains or water courses
Disposal Precautions: Employ personal protection when handling disposal, contact a licensed professional waste disposal service
UN Number: Consult relevant local listing or shipping documents (not commonly regulated under standard transport codes)
Proper Shipping Name: 4-Aminophenol hydrochloride, chemical not otherwise specified
Environmental Hazards: Keep substance secure during transit, prevent spillage
Special Transport Precautions: Isolate from food and animal feed, ensure secondary containment during transfer, comply with packaging standards for powders
Transport Regulations: Confirm with carriers for UN or hazard labels; may not ship as a dangerous good under certain modes, but safety data required for customs and documentation
OSHA Status: Hazardous
TSCA (USA): Listed
DSL/NDSL (Canada): Listed
REACH (Europe): Registration under standard intermediates and chemical inventory controls
WHMIS Classification: Identified as hazardous by criteria; ensure workplace labeling and employee training
SARA Title III: This chemical is not subject to specific SARA reporting requirements
State Regulations: Subject to right-to-know provisions in several US states
Other National/International Regulations: Review country-specific workplace and environmental controls prior to use
