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Product Name: 4,4'-Methylenedianiline
Synonyms: MDA, 4,4’-diaminodiphenylmethane
CAS Number: 101-77-9
Recommended Uses: Used as a curing agent for epoxy resins, intermediate in organic synthesis, and in polymer production
Manufacturer/Supplier: Contact details should be provided on container label for responsible party
Emergency Telephone: Available on industrial MSDSs or local poison center
Classification: Acute toxicity (oral, dermal, inhalation), skin sensitizer, suspected carcinogen, toxic to organs after repeated exposure
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin or inhaled; may cause allergy or asthma symptoms or breathing difficulties; causes skin and eye irritation; may cause cancer; may damage liver and other organs through prolonged or repeated exposure
Precautionary Statements: Do not breathe dust or vapor, wear protective clothing and gloves, use only in well-ventilated areas, wash hands thoroughly after handling, do not eat, drink, or smoke while using
Routes of Exposure: Skin contact, inhalation, ingestion
Chemical Name: 4,4’-Methylenedianiline
CAS Number: 101-77-9
Concentration: Typically supplied as pure compound or at concentrations over 95% for laboratory and industrial use
Impurities/Additives: May include trace amounts of related aromatic amines and chlorinated solvents depending on source and purity
Inhalation: Remove person to fresh air, keep at rest, seek immediate medical attention, administer oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing, rinse skin with copious amounts of water and soap, seek medical attention for irritation or persistent symptoms
Eye Contact: Rinse cautiously with water for at least 15 minutes, keep eyelids open to allow thorough flushing, consult a physician
Ingestion: Rinse mouth with water, do not induce vomiting, never give anything by mouth to an unconscious person, immediate medical treatment essential
Symptoms: Respiratory difficulty, cough, skin rash or redness, eye irritation, nausea, headache, potential delayed liver/kidney effects
Suitable Extinguishing Media: Use dry chemical, foam, or carbon dioxide, do not use water in a jet
Special Hazards: Toxic fumes of nitrogen oxides, carbon monoxide, and aniline derivatives may form during combustion or heating
Firefighter Protection: Self-contained breathing apparatus, chemical-resistant suit, avoid inhalation of combustion gases
Advice for Firefighters: Evacuate area, contain runoff, decontaminate protective gear after intervention
Personal Precautions: Avoid exposure, use gloves, chemical splash goggles, full-body suit, and proper respirator
Environmental Precautions: Prevent entry into drains, surface, and groundwater, inform authorities in case of environmental contamination
Spill Cleanup Methods: Soak up with inert absorbent material (e.g. sand, earth, vermiculite), collect in sealed containers for hazardous disposal, ventilate area, decontaminate spill surfaces
Handling: Handle in a well-ventilated chemical fume hood, avoid formation of dust and aerosols, do not breathe vapors, wash exposed skin after handling and before breaks; label all containers clearly
Storage: Store in tightly closed containers, cool, dry, and ventilated area away from light and incompatible chemicals (acids, oxidizers); avoid extreme temperatures
Specific End Uses: Industrial or laboratory reagent, always follow institutional chemical safety systems
Occupational Exposure Limits: OSHA PEL: 0.08 mg/m³ TWA (skin); ACGIH TLV: 0.01 ppm (inhalable fraction and vapor, skin)
Engineering Controls: Use local exhaust ventilation, safety shower and eyewash stations available; avoid open handling in non-controlled areas
Personal Protective Equipment: Nitrile or neoprene gloves, chemical splash goggles, lab coat, face shield as necessary, respiratory protection in case of inadequate ventilation
Hygiene Measures: Remove contaminated clothing and wash before reuse, wash hands thoroughly, do not eat or drink in work areas
Appearance: Pale yellow to brown crystalline solid
Odor: Slight aromatic odor
Melting Point: 88°C (190°F)
Boiling Point: 398°C (748°F)
Flash Point: 196°C (385°F)
Vapor Pressure: <0.01 mmHg (20°C)
Solubility: Slight in water; soluble in most organic solvents (alcohol, acetone, ether)
Density: 1.25 g/cm³ (20°C)
pH: Not applicable (non-aqueous solid)
Partition Coefficient n-octanol/water: log Kow: 1.58
Chemical Stability: Stable under recommended storage conditions; protects from moisture, light, and air when possible
Reactivity: Reacts vigorously with strong oxidizing agents and acids
Hazardous Reactions: Risk of violent exothermic reaction with oxidizers; may form hazardous decomposition products like aniline, carbon monoxide, nitrogen oxides
Conditions to Avoid: High temperatures, incompatible chemicals, direct sunlight, open flames
Incompatible Materials: Acid chlorides, anhydrides, strong acids and oxidizers
Acute Toxicity: LD50 oral (rat) ~ 285 mg/kg; LD50 dermal (rabbit) ~ 2,000 mg/kg
Irritation: Causes severe eye and skin irritation
Sensitization: Sensitizes skin on repeated contact
Carcinogenicity: Classified by IARC as Group 2B (possibly carcinogenic to humans); NTP and OSHA recognize as potential occupational carcinogen
Target Organ Effects: Liver, kidneys, blood
Routes of Entry: Inhalation, ingestion, dermal absorption
Symptoms of Exposure: Cough, shortness of breath, nausea, rash, liver tenderness
Ecotoxicity: Toxic to aquatic life with long-lasting effects
Persistence and Degradability: Poorly biodegradable, persists in soil and water
Bioaccumulation: Potential for accumulation in aquatic species (log Kow data suggest moderate risk)
Mobility in Soil: Moderate mobility, tends to adsorb to soil particles
Other Effects: Harmful to aquatic algaes, daphnia, fish at very low concentrations; environmental release restricts essential
Disposal Methods: Dispose through licensed chemical waste contractor; incinerate with afterburner and scrubber; avoid landfill or drain disposal
Container Handling: Empty containers must be decontaminated or disposed as hazardous waste; prevent reuse for other chemicals
Contaminated Packaging: Treat as hazardous waste; triple rinse and manage rinsate as hazardous waste
UN Number: UN 2651
Proper Shipping Name: 4,4’-Methylenedianiline
Hazard Class: 6.1 (Toxic substance)
Packing Group: III
Shipping Labels: Toxic; Marine Pollutant as required
Additional Information: Check local, national, and international regulations for specific requirements; keep away from foodstuffs during transport
OSHA Status: Regulated hazardous substance
SARA Title III: Listed under Section 313 for toxic chemical reporting
TSCA: Listed on US Toxic Substances Control Act
EU Classification: Carcinogen Category 2, environmental hazard
WHMIS: Controlled Product; Class D1A (very toxic material causing immediate and serious toxic effects), D2A (very toxic–other toxic effects)
Other Regulatory Info: Control measures required in many jurisdictions; restrictions apply to industrial and commercial use; safety data must accompany bulk shipments
