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Chemical Name: 3,3'-Dimethyl-4,4'-Diaminobiphenyl Hydrochloride
Synonyms: o-Tolidine dihydrochloride
Product Code: 32600
Recommended Use: Intermediate in dye and pigment manufacturing, laboratory reagent
Manufacturer: Provided by supplier upon request
Emergency Contact: Information available on manufacturer’s official website or product label
CAS Number: 612-82-8
EC Number: 210-332-1
Classification: Acute toxicity (oral, dermal, inhalation), Skin irritation, Eye damage, Carcinogenicity
Label Elements: Danger, Skull and Crossbones, Corrosive, Health Hazard pictograms
Hazard Statements: Harmful if swallowed, causes skin irritation, causes serious eye damage, may cause cancer
Precautionary Statements: Avoid breathing dust or vapors, wash thoroughly after handling, wear protective gloves, protective clothing, eye protection, face protection, obtain special instructions before use, do not handle until all safety precautions have been read and understood
Other Hazards: Can cause allergic skin reaction, prolonged exposure can aggravate respiratory or skin issues
Chemical Identity: 3,3'-Dimethyl-4,4'-Diaminobiphenyl Hydrochloride
Common Name: o-Tolidine Di-hydrochloride
CAS Number: 612-82-8
Percentage: 97–100% by weight
Impurities: Trace amounts of related diamines, hydrochloric acid residues
Additional Information: No stabilizing additives present
Inhalation: Move affected individual to fresh air, keep comfortable in a position for breathing ease, seek immediate medical attention for difficulty breathing or irritant symptoms
Skin Contact: Remove contaminated clothing, rinse skin with copious water and gentle soap for at least 15 minutes, consult a physician if irritation persists
Eye Contact: Flush both eyes gently with water for at least 15 minutes while holding eyelids apart, remove contact lenses after initial rinse, seek medical advice
Ingestion: Rinse mouth, do not induce vomiting, offer water to drink, contact poison control or emergency center immediately, provide symptom description to healthcare personnel
Symptoms and Effects: Redness, burning, itching of skin or eyes, coughing, sore throat, abdominal pain, risk of serious delayed effects with repeat exposures
Suitable Extinguishing Agents: Water spray, dry chemical, alcohol-resistant foam, carbon dioxide
Unsuitable Extinguishing Methods: Do not use water jets for fire fighting, may spread the material
Specific Hazards: Emits toxic fumes of nitrogen oxides, carbon monoxide, and hydrochloric acid during combustion
Protective Equipment: Wear self-contained breathing apparatus, full chemical protective clothing
Firefighting Instructions: Approach fire from upwind direction, use water spray to cool containers exposed to fire, avoid inhaling combustion gases, maintain a safe distance
Personal Precautions: Evacuate non-essential personnel, avoid dust generation, ventilate area, wear proper personal protective gear including respirator, gloves, and goggles
Environmental Precautions: Prevent further spillage or entry into drains, soil, or watercourses using absorbent barriers and proper diking
Methods for Cleaning Up: Sweep or vacuum up without generating dust, place material in sealed and labeled waste containers, wash spill site with copious water after material pick-up
Reference to Other Sections: See exposure controls for recommended protective equipment and see disposal information for waste handling
Safe Handling: Keep work area clean, avoid breathing dust and skin or eye contact, use approved chemical fume hood or local exhaust ventilation, do not eat, drink, or smoke during use
Incompatible Materials: Avoid contact with strong acids and bases, oxidizing agents, reducing agents
Handling Precautions: Use only with adequate ventilation, dispense using clean and dry tools, keep away from sources of ignition
Storage Requirements: Store in tightly closed container, keep dry in original packaging, refrigerate or store at ambient temperature as manufacturer recommends, protect from direct sunlight and moisture
Special Considerations: Label all containers, keep apart from food, feed-stuffs, and incompatible chemicals, control access to authorized personnel
Occupational Exposure Limits: Consult national and local guidelines for limits, suggested < 0.1 mg/m³ for chronic exposure
Engineering Controls: Use laboratory fume hood or exhaust ventilation, work with containment methods to control airborne particles, install eyewash and safety showers nearby
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), long-sleeved protective clothing, chemical safety goggles, face shield for splash risk
Respiratory Equipment: Use NIOSH/MSHA or EN-approved particulate respirator where ventilation is not adequate
Hygiene Measures: Remove and wash contaminated clothing, wash hands thoroughly after handling, avoid bringing material home via clothing or equipment
Appearance: Off-white to light brown crystalline powder
Odor: Mild amine-like scent
Odor Threshold: Not established
pH: Approximately 5–6 (1% aqueous solution)
Melting Point: >300°C with decomposition
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not determined
Evaporation Rate: Not applicable for solids
Flammability: Not classified as flammable but combustible at elevated temperatures
Vapor Pressure: Negligible at room temperature
Solubility in Water: Freely soluble
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not established
Decomposition Temperature: >300°C
Viscosity: Not applicable (solid)
Reactivity: Stable under normal laboratory conditions
Chemical Stability: Stable at ambient temperatures, avoid excessive heat and moisture
Hazardous Reactions: May react with strong oxidizers or reducing agents, violent reaction with concentrated acids possible
Conditions to Avoid: Avoid direct sunlight, heat sources, high humidity, strong acids, alkalis, and oxidizers
Hazardous Decomposition Products: Forms nitrogen oxides, carbon oxides, hydrogen chloride on thermal decomposition
Routes of Exposure: Inhalation, skin, ingestion, eye contact
Acute Toxicity: Harmful if swallowed, inhaled, or absorbed through skin; animal studies show organ toxicity with high exposures
Skin/Eye Irritation: Causes moderate to severe irritation, risk of burns with prolonged contact
Respiratory Sensitization: Prolonged inhalation exposure may cause asthma-like symptoms or increased sensitivity
Carcinogenicity: Listed as possible human carcinogen (IARC Group 2B); epidemiological studies link chronic exposure with bladder cancer
Mutagenicity: Evidence from laboratory studies supports genetic mutagen potential
Reproductive Effects: Not well studied; minimize exposure as precaution
Chronic Effects: Repeated exposure linked with blood disorders, skin discoloration, changes in liver and kidney function
Symptoms from Exposure: Skin rash, dizziness, abdominal pain, cough, potential delayed neurotoxicity
Aquatic Toxicity: Harmful to aquatic organisms, risk of long-term adverse effects in water environments
Mobility: Compound spreads in water, binds weakly to soil, possible contamination of groundwater if released
Persistence: Slowly biodegradable, can persist in sediment and water for months
Bioaccumulation: May accumulate in aquatic organisms, not readily eliminated once absorbed
Other Adverse Effects: Toxicity extends to some terrestrial species, air emissions may present secondary risks through transformation products
Waste Treatment Methods: Collect and label as hazardous chemical waste
Product Disposal: Incinerate at licensed chemical waste facility, do not dispose through municipal drains or landfill
Packaging Disposal: Rinse containers and treat rinse liquid as hazardous waste, triple-rinse containers before discarding
Regulations: Follow all local, state, and national hazardous waste management regulations
Other Recommendations: Consult licensed professional disposal service, keep waste separate from organic or flammable substances
UN Number: UN3439
UN Proper Shipping Name: Amines, solid, corrosive, n.o.s. (contains 3,3'-Dimethyl-4,4'-Diaminobiphenyl Hydrochloride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Environmental Hazard: Marine pollutant
Special Transport Precautions: Well-sealed, labeled according to regulations, keep separate from food and feed, avoid extreme heat
International Transport Rules: IMDG, IATA, RID, and ADR apply for overseas shipping
EU Regulations: Listed in REACH, classified as hazardous under CLP (EC 1272/2008)
US Regulations: Covered by TSCA, CERCLA, SARA Title III, and OSHA standards; may be subject to reporting and handling restrictions for carcinogens
Canadian Regulations: Listed on DSL; subject to WHMIS classification E (Corrosive Material), D2A (Very Toxic Material), D2B (Toxic Material requiring special handling)
Other Country Regulations: Refer to national inventories and workplace safety standards
Labeling Requirements: Consistent with GHS mandates, includes pictograms, hazard, and precautionary phrases in English and regional language
Restrictions: Limited for public use, only authorized industrial and professional users may purchase or handle
Training: Staff handling this substance must complete certified chemical safety training, informed of carcinogenic potential and environmental risks
