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Product Name: 3-Octanone
Synonyms: Ethyl amyl ketone, Octan-3-one
CAS Number: 106-68-3
EC Number: 203-419-9
Recommended Use: Used in flavor and fragrance formulations, organic synthesis
Manufacturer Information: Provided by supplier or distributor contact
Emergency Phone: Access through emergency service or chemical response team
Address: As listed by manufacturer or supplier
GHS Classification: Flammable liquid (Category 3), Eye irritation (Category 2A), Acute aquatic hazard (Category 3)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, Flammable liquid and vapor, Harmful to aquatic life
Pictograms: Flame, Exclamation mark
Precautionary Statements: Keep away from heat and open flames, Avoid breathing vapors, Wear protective gloves and eye/face protection, Keep container tightly closed
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Potential Health Effects: Can irritate eyes and skin, inhalation may cause respiratory discomfort, ingestion may lead to nausea or dizziness
Chemical Name: 3-Octanone
Common Names: Ethyl amyl ketone
CAS Number: 106-68-3
Concentration: Typically 98-100% for laboratory grade, presence of impurities possible at trace levels
Other Components: Minor amounts of related ketones, nonhazardous impurities may be present depending on source
Inhalation: Move affected person to fresh air, provide oxygen if breathing is difficult, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash affected skin area thoroughly with soap and water, contact a doctor if irritation occurs
Eye Contact: Flush eyes immediately with plenty of water for 15 minutes, lift eyelids to ensure thorough rinsing, consult an ophthalmologist if irritation remains
Ingestion: Rinse mouth with water, do not induce vomiting, offer water to dilute, seek medical help immediately, give symptomatic treatment as needed
Symptoms to Watch: Eye redness or pain, skin rash, headache, nausea, dizziness
Notes for Physician: Treat symptomatically based on the patient’s clinical condition; ensure airway and breathing support if required
Suitable Extinguishing Media: Use alcohol-resistant foam, dry chemical powder, CO2 extinguisher, or water spray for larger fires
Unsuitable Media: Avoid direct water jet, risk of spreading fire
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, potentially irritating vapors or smoke
Special Protective Equipment: Firefighters must use self-contained breathing apparatus and chemical protective clothing
Fire Hazards: Vapors can travel and ignite at a distance from spill; containers exposed to heat may explode
Specific Measures: Remove combustible material from area, cool containers with water spray
Personal Precautions: Evacuate unprotected personnel, ventilate area, avoid inhaling vapors, wear suitable protective equipment
Environmental Precautions: Prevent entry into sewers, drains, or waterways, contact local authorities if release threatens environment
Spill Cleanup Methods: Contain and collect spill with inert absorbent (sand, earth, vermiculite), place in containers for disposal
Decontamination: Clean residue with detergent and water, ventilate area, check for hazardous concentrations before re-entry
Large Spill Response: Use diking for large spills, consult emergency response teams as needed
Safe Handling Practices: Avoid inhaling vapors, use only in well-ventilated spaces, keep away from ignition sources, ground/bond containers, avoid contact with skin and eyes
Storage Conditions: Store in tightly closed, properly labeled containers, keep in a cool, dry, well-ventilated place away from incompatible materials
Incompatible Materials: Strong oxidizing agents, acids, acid chlorides, reducing agents
Storage Life: Stable under recommended storage conditions, usually up to 1-2 years unopened; check for decomposition or discoloration
Other Precautions: Install spill containment systems, establish emergency wash stations nearby, follow site-specific chemical hygiene protocols
Occupational Exposure Limits: No established limits for 3-Octanone; minimize exposure to airborne vapor and mist
Engineering Controls: Use local exhaust ventilation, fume hoods, and mechanical ventilation if needed
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or neoprene), safety goggles or full-face shield, flame-resistant lab coat, impervious footwear, use a certified respirator for high vapor concentrations
Hygiene Measures: Wash hands after handling, avoid eating, drinking, or smoking in handling areas, change contaminated clothing promptly
Environmental Exposure Controls: Use closed systems for transfer, filter or scrub air emissions if venting externally
Appearance: Colorless to pale yellow liquid
Odor: Fruity, sweet, herbaceous
Odor Threshold: Detectable at low concentrations
Molecular Formula: C8H16O
Molecular Weight: 128.21 g/mol
Boiling Point: 173–175°C
Melting Point: -55°C
Flash Point: 61°C (closed cup)
Auto-ignition Temperature: 255°C
Upper/Lower Explosion Limits: Upper limit 7.0%, lower limit 0.9% (v/v)
Vapor Pressure: 0.5 mmHg at 20°C
Vapor Density: ~4.4 (air = 1)
Solubility in Water: Slight (<1 g/L)
Partition Coefficient (log Pow): 2.88
Evaporation Rate: Moderate, similar to typical ketones
Viscosity: Low, flows easily at standard temperatures
Chemical Stability: Stable at ambient temperatures and pressures, sensitive to strong oxidizers
Conditions to Avoid: Sources of ignition, heat, sunlight, static discharge
Incompatible Substances: Strong acids, oxidizing agents, alkali metals, reducing agents
Hazardous Decomposition Products: Thermal decomposition produces carbon monoxide, carbon dioxide, fumes
Risk of Hazardous Reactions: No hazardous polymerization expected under recommended use and storage
Reactivity Notes: Similar to other aliphatic ketones; avoid strong acids or chlorinating agents
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rats) approx. 3200 mg/kg, lower toxicity than many ketones
Skin Corrosion/Irritation: Mild to moderate skin irritant; repeated exposure may cause dermatitis
Serious Eye Damage/Irritation: Causes moderate to strong eye irritation
Respiratory Effects: High vapor concentrations may cause headaches, dizziness, drowsiness, or nausea
Chronic Effects: No carcinogenic, mutagenic, or reproductive toxicity data identified; long-term exposure to solvent vapors may impact nervous system
Sensitization: No specific skin or respiratory sensitization data available
Target Organs: Eyes, skin, central nervous system
Symptoms: Eye redness/watering, skin redness, throat irritation, dizziness
Ecotoxicity: Harmful to aquatic organisms, may cause long-term effects in aquatic environments
Persistence and Degradability: Expected to biodegrade in environment, not persistent under aerobic conditions
Bioaccumulative Potential: Moderate log Pow suggests limited potential for bioaccumulation
Mobility in Soil: Low to moderate mobility, likely to volatilize from soil and water surfaces
Other Harmful Effects: Spills may contribute to oxygen depletion in water bodies; no known significant impact on plant or wildlife at low concentrations
Disposal to Waterways: Prohibited; avoid contamination of groundwater and storm drains
Waste Treatment Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber, or dispose through licensed chemical waste contractor
Container Disposal: Rinse residue from container, triple rinse, then deliver for regulated waste disposal
Environmental Precautions: Collect and contain waste to prevent uncontrolled release, notify relevant authorities in event of significant spill
Local Regulations: Follow all local/national controls for hazardous chemical waste
Reuse/Recycle: Only recycle uncontaminated unused chemical through industry-approved recovery systems
Special Precautions: Avoid disposal by discharge to environment, especially aquatic systems
UN Number: 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (3-Octanone)
Transport Hazard Class: 3 – Flammable liquids
Packing Group: III
Environmental Hazards: Not classified as marine pollutant but use best practices to prevent environmental release
Special Precautions: Keep containers upright and secured, follow regulations for flammable liquids shipment, ensure labels remain intact and legible
Regulatory Information: Compliance with IATA, IMDG, ADR, DOT required for international and domestic shipping
GHS/CLP: Classified as hazardous per GHS criteria
OSHA: Regulated under Hazard Communication Standard (29 CFR 1910.1200)
TSCA: Listed on US TSCA Inventory
REACH: Registered substance under EC 1907/2006; observe European safety requirements
Other Regulations: Covered by workplace right-to-know and safety legislation in most countries
Labeling: Proper safety labeling required in all storage and transportation
Worker Protection: Training required for those handling materials, emergency procedures to be displayed in workplaces
