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Product Name: 3-Nitroiodobenzene
Synonyms: m-Nitroiodobenzene, 1-Iodo-3-nitrobenzene
Chemical Formula: C6H4INO2
CAS Number: 636-98-6
Recommended Use: Organic synthesis, research
Supplier: Refer to manufacturer or laboratory information
Emergency Contact: Refer to local guidelines for chemical emergencies
Importer/Distributor: Consult package or regional regulations for company identity
Classification: Acute toxicity - Oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2), Specific target organ toxicity - single exposure (Category 3)
Label Elements: Exclamation mark, toxic hazard, environmental hazard symbols
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: Avoid breathing dust or fumes. Wash hands thoroughly after handling. Wear protective gloves, eye protection, and face protection. Use only outdoors or in a well-ventilated area. Avoid release to the environment.
Other Hazards: Not classified as a PBT or vPvB substance, but releases iodine and nitro-compounds on breakdown. Solid dust can cause irritation to respiratory tract.
Chemical Name: 3-Nitroiodobenzene
PURITY: ≥98%
CAS Number: 636-98-6
EC Number: 211-265-8
Impurities: Trace amounts of 2-nitroiodobenzene, 4-nitroiodobenzene may be present in minute quantities. No other relevant impurities anticipated above regulatory threshold.
Inhalation: Remove person to fresh air immediately. Maintain breathing. Seek medical attention for persistent symptoms like coughing, throat irritation, or shortness of breath.
Skin Contact: Rinse affected area with water for at least 15 minutes. Remove contaminated clothing. Do not apply chemical neutralizers. If irritation or rash develops, medical attention is necessary.
Eye Contact: Flush eyes continuously with clean running water for 15 minutes. Remove contact lenses if possible. Prompt medical attention required to assess for damage.
Ingestion: Rinse mouth with water. Do not induce vomiting unless advised by medical professionals. If victim feels unwell or displays any symptoms such as nausea, headache, or abdominal pain, seek immediate medical attention.
Note to Physicians: Symptomatic treatment. Provide supportive care with attention to respiratory and gastrointestinal systems.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray tailored to the surrounding fire.
Unsuitable Extinguishing Media: Do not use strong water jets as they may disperse the material.
Specific Hazards: Decomposition releases toxic fumes of iodine, nitrogen oxides, carbon oxides, and potentially hydrogen iodide.
Protective Equipment: Firefighters need full turnout gear, self-contained breathing apparatus with positive-pressure mode to prevent inhalation of hazardous decomposition gases.
Further Information: Cool fire-exposed containers with water spray to prevent rupture. Contain runoff as it may pollute surface water. Avoid direct contact with smoke or chemical byproducts.
Personal Precautions: Evacuate area, ventilate location of spill. Use chemical splash goggles, appropriate gloves, and protective clothing.
Environmental Precautions: Prevent release into drains, soil, groundwater, or waterways. Notify authorities if seepage occurs.
Methods for Cleanup: Gather solids by mechanical means using spark-proof tools and dispose of in labeled containers. Avoid dust generation. Wash area with water after material removal.
Reference to Other Sections: See sections on exposure controls and disposal for further guidance.
Safe Handling: Operate within chemical fume hood or with adequate ventilation. Minimize direct handling; transfer using tools. Wash hands after use.
Storage Conditions: Store in a cool, dry, ventilated space. Keep container tightly closed and away from strong acids, bases, and oxidizing agents.
Incompatible Materials: Reacts vigorously with alkali metals, strong oxidants, and reducing agents.
Specific End Uses: Apply for research, synthesis, and not for human consumption, food, or drug application.
Other Handling Notes: Isolate from food areas. Avoid mechanical shock to containers. Keep inventory records and restrict access to trained individuals.
Control Parameters: No established occupational exposure limits for 3-Nitroiodobenzene as of the latest regulatory reviews.
Engineering Controls: Use fume hood or local ventilation to minimize airborne concentrations. Use closed processing systems for large quantities.
Personal Protective Equipment: Safety goggles, chemical-resistant gloves (such as nitrile), protective lab coat, and suitable dust mask (P2 or N95 equivalent for solid particles). In case of large release, use a full-face respirator with HEPA or combination cartridge.
Hygiene Measures: Do not eat or drink in handling areas. Remove contaminated clothing and wash hands before breaks or leaving the workplace.
Environmental Controls: Collect and treat exhaust effluents via filters or scrubbers. Do not release into the environment without official permits.
Appearance: Yellow solid in crystalline or powdered form
Odor: Slight, pungent odor
Odor Threshold: Not established
pH: Not applicable as solid, not water soluble
Melting Point: 123–126°C
Boiling Point: Not easily achievable under atmospheric pressure (decomposes before boiling)
Flash Point: Not available (combustible solid)
Evaporation Rate: Not relevant
Flammability: Not highly flammable but combustible
Vapor Pressure: Non-volatile at room temperature
Solubility: Practically insoluble in water; soluble in acetone, chloroform, ethanol
Partition Coefficient (n-octanol/water): Not measured, expected to be high due to hydrophobicity
Vapor Density: Not established
Relative Density: Around 2.15 g/cm³
Auto-Ignition Temperature: Not available
Decomposition Temperature: Begins to decompose above 150°C
Viscosity: Not applicable
Molecular Weight: 265.01 g/mol
Chemical Stability: Stable under normal laboratory conditions and storage. Sensitive to light, prolonged exposures degrade product quality.
Reactivity: Inert toward most laboratory solvents. Undergoes nitration and iodination reactions under harsh conditions.
Possible Hazardous Reactions: Contact with reducing agents liberates iodine. Avoid contact with acids and alkali metals.
Conditions to Avoid: Elevated temperatures, direct sunlight, moisture, static discharge, presence of strong acids or bases.
Incompatible Materials: Alkali metals, strong oxidizing agents, reducing agents, bases.
Decomposition Hazards: Releases iodine, nitro compounds, nitrogen dioxide, volatile organics on breakdown.
Acute Toxicity: Data on animal oral LD50 indicate moderate toxicity (rat oral LD50 estimated between 200-2000 mg/kg). Effects include headaches, dizziness, nausea.
Skin Corrosion/Irritation: Direct contact causes redness, irritation, possible burns with prolonged exposure.
Serious Eye Damage/Irritation: Irritating to eyes, may cause watering, conjunctivitis, or blurred vision temporarily.
Respiratory Effects: Inhalation can irritate airways, exacerbating respiratory conditions in sensitive individuals.
Chronic Effects: Prolonged or repeated exposure may contribute to thyroid dysfunction due to iodine moiety; data insufficient for carcinogenicity, mutagenicity, or reproductive toxicity in humans.
Other Information: No confirmed human case reports of poisoning with this compound, but cautious handling remains essential.
Ecotoxicity: No experimental aquatic toxicity data, but by analogy with related nitro- and iodine-compounds, may pose hazards to aquatic life, especially invertebrates, fish, and algae.
Mobility in Soil: Low mobility due to low water solubility and high sorption to soil organic matter.
Persistence and Degradability: Likely persistent, resistant to biodegradation based on aromatic nitro structure.
Bioaccumulative Potential: Strong tendency to bioaccumulate based on predicted partition coefficient (log Kow > 3).
Other Adverse Effects: Decomposition products can bioaccumulate and cause disruption in aquatic food chains.
Precaution: Prevent release to surface water and soil. Inform appropriate environmental agencies in case of large spillage.
Waste Disposal: Dispose through licensed chemical waste contractors. Do not pour into drains or municipal waste streams.
Contaminated Packaging: Treat packaging as hazardous. Clean completely before recycling or incinerate via approved facility. Label and store containers until collection.
Special Precautions: Consult local, regional, and national guidance for chemical waste classifications. Adhere to standards of US Resource Conservation and Recovery Act (RCRA) or European Waste Catalogue (EWC) as appropriate.
UN Number: Not regulated under UN Model Regulations for Transport of Dangerous Goods.
Proper Shipping Name: 3-Nitroiodobenzene
Transport Hazard Class: Not classified as hazardous for land (ADR/RID), air (IATA), or sea (IMDG) shipments, if packed properly.
Packing Group: Not assigned
Environmental Hazards: Avoid exposure to water or release into environment during transport.
Special Transport Precautions: Protect against rough handling, moisture, and excessive heat during transit. Secure containers against shifting or rupture.
EU Regulations: Not classified as a substance of very high concern (SVHC) or subject to Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) restrictions as of last revision. Follow General Product Safety Directive and CLP guidelines.
US Regulations: Not explicitly listed in federal regulations such as TSCA, CERCLA, or SARA Title III as a hazardous chemical; local state regulations may apply.
International Inventories: Notified to EINECS, present in Canadian DSL, Japanese ENCS, and Australian AICS inventories. Check specific jurisdiction for most current status.
Other Guidance: Laboratory personnel should review site-specific chemical safety protocols. Users must consult regular updates from regulatory authorities for new risk data or restrictions.
