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Chemical Name: 3-Nitrobromobenzene
Other Names: m-Bromonitrobenzene
Chemical Formula: C6H4BrNO2
Molecular Weight: 202.01 g/mol
Recommended Use: Intermediate for organic synthesis, research and analytical chemistry
Supplier Contact: Emergency phone and address details should be kept ready for consultation before use
CAS Number: 585-79-5
Physical State: Solid, crystalline powder
Color: Pale yellow with a faint aromatic odor
GHS Classification: Acute Toxicity (oral, dermal), Eye Irritant, Skin Irritant
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled. Causes serious eye irritation. Causes skin irritation. May cause respiratory discomfort.
Pictograms: Exclamation mark
Precautionary Statements: Wear gloves, goggles, and a lab coat. Avoid breathing dust. Wash hands thoroughly after handling. Do not eat or drink near work area. Avoid release to the environment.
Chemical Identity: 3-Nitrobromobenzene
Purity: Over 98% for laboratory-grade batches
Impurities / Additives: Traces of unreacted nitrobenzene or bromobenzene, usually below detectable limits
Hazardous Components: No other ingredients contribute significantly to hazards according to OSHA criteria
Eye Contact: Immediately flush with water for at least 15 minutes, keeping eyelids apart. Seek medical attention if irritation or vision changes occur.
Skin Contact: Remove contaminated clothing, wash exposed skin with soap and water. If irritation develops, consult a medical professional.
Inhalation: Move to fresh air right away. Provide oxygen if breathing is difficult. Seek immediate medical attention for persistent symptoms.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by a healthcare provider. Never give anything by mouth to an unconscious person. Get medical help.
Most Important Symptoms: Burning in eyes, redness of skin, coughing, difficulty breathing, digestive discomfort if swallowed
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide. Do not use water jet directly.
Special Hazards from Combustion: Releases toxic fumes including nitrogen oxides, bromine vapors, carbon monoxide. Smoke may reduce visibility.
Protective Equipment: Firefighters need full protective gear, self-contained breathing apparatus.
Other Recommendations: Keep drums cool by spraying with water to prevent rupture from heat. Move containers from fire area if possible without risk.
Personal Precautions: Put on suitable PPE including respiratory protection and goggles. Evacuate the area if dust clouds form. Avoid breathing dust.
Environmental Precautions: Prevent release into sewers, soil, rivers, or lakes. Inform relevant authorities if environmental contamination occurs.
Methods for Cleanup: Sweep up carefully without raising dust, and place in containers for disposal according to regulations. Ventilate area. Clean contaminated surfaces with soap and water. Double-bag all debris if sending to a landfill.
Safe Handling: Use only in well-ventilated labs with chemical fume hoods. Avoid inhaling dust, skin, or eye contact. Do not eat, drink, or smoke during use. Wash hands and skin thoroughly before breaks and after work.
Storage Conditions: Store tightly sealed in labeled containers. Keep in a dry, cool, well-ventilated location away from sources of heat or ignition, strong acids, bases, and reducing agents.
Other Practices: Protect from direct sunlight and moisture. Separate from food and incompatible chemicals. Keep inventory logs for traceability.
Occupational Exposure Limits: Not established for this specific substance, but best practice relies on local regulations for comparable aromatic nitro compounds.
Engineering Controls: Use fume hoods, local exhaust ventilation, and closed systems if possible.
Personal Protective Equipment: Chemical-resistant gloves (nitrile suggested), safety goggles with side-shields, lab coat, dust mask or respirator if potential for dust inhalation.
General Hygiene: Keep work area clean, avoid cross-contamination, and launder clothing after handling.
Appearance: Pale yellow solid, crystalline
Odor: Slightly aromatic
Melting Point: 80-82°C
Boiling Point: 276-278°C (decomposes)
Solubility: Poorly soluble in water, better in ethanol, ether, acetone
Density: Approximately 1.8 g/cm³
Vapor Pressure: Low at room temperature
pH: Not applicable (solid compound, non-aqueous)
Partition Coefficient (Log Pow): Around 2–3 (estimate)
Flash Point: Not applicable (non-volatile solid at room temperature)
Chemical Stability: Stable under standard laboratory conditions, away from incompatible substances. Deteriorates at high temperature.
Conditions to Avoid: Open flames, heat, sparks, direct sunlight, and moisture.
Incompatible Materials: Strong reducing agents, strong bases, and acids. Avoid mixing with combustible substances.
Hazardous Decomposition Products: Toxic gases: nitrogen oxides, bromine, COx.
Polymerization: Not known to polymerize under normal use.
Acute Toxicity: Harmful by ingestion, inhalation, or skin absorption. Oral LD50 (mouse or rat, estimated): 300–2000 mg/kg depending on source.
Skin Corrosion/Irritation: Skin contact may cause redness, irritation.
Serious Eye Damage/Irritation: Causes pain, redness, watering. Possible corneal injury with prolonged exposure.
Respiratory Sensitization: Prolonged inhalation may cause respiratory irritation or difficulty breathing.
Chronic Effects: Repeated exposure may cause blood or hepatic changes (based on nitroaromatic compound toxicity profiles). Not classified as carcinogenic by IARC.
Other Effects: Allergic skin reactions are possible in susceptible individuals.
Toxicity to Aquatic Life: Harmful to aquatic organisms. Acute aquatic toxicity (Daphnia, fish): low mg/L range (estimated based on similar nitro-aromatic compounds).
Persistence and Degradability: Compound is not readily biodegradable. Persists in soil and water for extended periods.
Bioaccumulation Potential: Moderate bioaccumulation possible due to log Pow values above 2. Could accumulate in higher trophic levels if released in significant quantities.
Mobility in Soil: Moderately mobile in soil, potential for leaching to groundwater.
Other Adverse Effects: No evidence of widespread environmental impact, but excessive release can locally disrupt aquatic life.
Waste Handling: Dispose of unused material and contaminated packaging as hazardous waste, using approved chemical disposal services.
Methods for Disposal: Chemical incineration in an approved facility with afterburner and scrubber for nitrogen oxides. Contaminated solids need to be segregated and labeled.
Prevent Release: Avoid dilution in drains or sewage lines. Never mix with household waste.
Regulations: Disposal must follow all federal, state, and local environmental control regulations.
UN Number: 2811
UN Shipping Name: Toxic solid, organic, n.o.s. (contains 3-Nitrobromobenzene)
Hazard Class: 6.1 (Toxic substances)
Packing Group: III (minor hazard)
Labeling Requirements: Toxic solid, keep labels legible on all containers. Mark with "Marine Pollutant" if transported by sea.
Special Precautions: Transport in tightly closed original containers, upright, away from food, animal feed, and incompatible chemicals.
Transport Regulations: Subject to regulations under ADR/RID, IMDG, IATA as a toxic solid.
US Regulations: Subject to OSHA hazards. Listed in TSCA inventory. SARA 313 reporting required for certain users.
European Regulations: Included in REACH registry. Labeling according to CLP/GHS (Hazard symbols and warning phrases).
Other International Standards: Included in Canadian DSL/NDSL. Subject to chemical control in Japan and China. Requires environmental release monitoring in most industrial settings.
Workplace Hazard Communication: Safety training and information sheets need regular updating. Accessible to all laboratory and transport personnel.
