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Product Name: 3-Nitroanisole
Chemical Formula: C7H7NO3
CAS Number: 604-25-3
Other Names: m-Nitroanisole, m-Methoxynitrobenzene
Recommended Use: Laboratory reagent, intermediate in chemical manufacturing
Supplier Info: Reference local distributor or supplier details
Emergency Contact: Refer to local emergency services or poison control center
GHS Classification: Harmful if swallowed or inhaled, causes skin and eye irritation
Hazard Symbols: Exclamation Mark, Health Hazard
Signal Word: Warning
Hazard Statements: Harmful if swallowed. May cause respiratory irritation and possible damage with prolonged exposure.
Precautionary Statements: Avoid inhalation of dust, fumes, or vapors. Wash thoroughly after handling. Do not eat, drink, or smoke when using this material.
Pictograms: GHS07 (Exclamation mark)
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Chemical Name: 3-Nitroanisole
Synonyms: m-Nitroanisole
Content: ≥99% pure
Impurities: Not expected to contain impurities contributing to classification
Inhalation: Remove victim to fresh air. Provide oxygen if breathing is difficult. Seek medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing. Wash skin with plenty of water and soap for several minutes.
Eye Contact: Rinse thoroughly with plenty of water for several minutes, lifting eyelids occasionally. Seek medical attention.
Ingestion: Rinse mouth; do not induce vomiting. Seek immediate medical advice.
Most Important Symptoms: Coughing, irritation of the respiratory tract, headache, dizziness, possible allergic reaction on repeated contact
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Media: None identified
Hazardous Combustion Products: Emits toxic fumes such as nitrogen oxides and carbon oxides upon burning
Protective Equipment: Full protective clothing, self-contained breathing apparatus (SCBA)
Advice for Firefighters: Control spill and water runoff; fight fire from safe distance; use water spray to cool unopened containers
Personal Precautions: Evacuate area, ensure adequate ventilation, avoid breathing dust or vapor
Environmental Precautions: Prevent further leakage or spillage if safe to do so; avoid release to the environment
Methods for Clean-Up: Collect and place spilled material in closed containers for disposal. Clean contaminated surface thoroughly. Use proper personal protective equipment
Spill Control: Wear personal protective gear; absorb spill with inert material such as sand; ventilate area; do not allow product to reach drains or water sources
Handling: Handle with care in well-ventilated space. Avoid contact with skin, eyes, and clothing. Prevent formation of dust and aerosols.
Storage: Store in a tightly closed container, in a cool, dry, well-ventilated area. Separate from incompatible materials such as oxidizers, acids, and bases.
Safe Practices: Wash thoroughly after handling; keep container closed when not in use; store away from food and beverages
Occupational Exposure Limits: No established limits for 3-Nitroanisole; use general dust/vapor controls
Engineering Controls: Work in a chemical fume hood or provide adequate general ventilation
Personal Protective Equipment: Protective gloves (nitrile), tightly fitting safety goggles, lab coat; respiratory protection when higher concentrations or lack of ventilation
Hygiene Measures: Do not eat, drink, or smoke during handling; wash hands after use
Environmental Exposure Controls: Use containment to prevent environmental contamination
Appearance: Pale yellow crystalline solid
Odor: Slight aromatic odor
Molecular Weight: 153.14 g/mol
Melting Point: 40–44°C
Boiling Point: 274–275°C
Solubility: Slightly soluble in water, soluble in organic solvents
Vapor Pressure: Very low at room temperature
Density: 1.28 g/cm³
pH: Not applicable
Flash Point: Above 110°C
Partition Coefficient (log Kow): About 1.7
Autoignition Temperature: Not available
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Not considered reactive under recommended conditions
Hazardous Reactions: Strong oxidizers can cause fire or explosion.
Decomposition Products: Toxic gases such as nitrogen oxides and carbon monoxide can result from thermal decomposition
Incompatible Materials: Strong oxidizing agents, acids, strong bases
Acute Toxicity: Harmful if swallowed or inhaled; LD50 (oral, rat): 2,800 mg/kg
Skin Irritation: May cause irritation on repeated or prolonged contact
Eye Irritation: Can provoke irritation
Inhalation Effects: Respiratory tract irritation, coughing, possible central nervous system effects (headache, dizziness)
Chronic Effects: Prolonged or repeated exposure could cause dermatitis, possible sensitization
Carcinogenicity: Not classified as carcinogenic by IARC or NTP
Mutagenicity: Not mutagenic based on available data
Other Data: No evidence available for reproductive toxicity
Aquatic Toxicity: Moderately toxic to aquatic life, based on chemical structure and case comparisons
Persistence and Degradability: Not readily biodegradable
Bioaccumulation Potential: Expected to have low bioaccumulation due to moderate log Kow
Mobility in Soil: Limited mobility anticipated because of low water solubility
Other Adverse Effects: Prevent product from entering water sources and soil
Waste Treatment Methods: Dispose of as hazardous waste per local regulations.
Waste Packaging: Use approved containers for chemical waste disposal
Handling Contaminated Packaging: Rinse thoroughly; treat as chemical waste
Disposal Restrictions: Never discharge into environment, soil, or sewers
Additional Information: Consult waste disposal authority for classification and disposal guidance
UN Number: Not regulated for transport under most national and international rules
Transport Hazard Class: Not classified as hazardous for transport
Packing Group: Not assigned
Proper Shipping Name: 3-Nitroanisole
Special Precautions: Avoid spillage or exposure during loading and transport; ensure secure packaging
Environmental Hazards: Not classified as marine pollutant
TSCA (US): Listed
EINECS/ELINCS (EU): Listed (210-000-2)
OSHA: No specific PEL established
WHMIS (Canada): D2B (Toxic material causing other toxic effects)
REACH (EU): Not registered; for laboratory and research use
Other Regulations: Follow local regulations for safe chemical handling and reporting
