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Product Name: 3-Nitroaniline
Chemical Formula: C6H6N2O2
Synonyms: m-Nitroaniline, 1-Amino-3-nitrobenzene
CAS Number: 99-09-2
Molecular Weight: 138.12 g/mol
Manufacturer: Refer to label or supplier details
Recommended Use: Intermediate in dyes, pharmaceuticals, chemical synthesis
Restrictions on Use: For industrial and laboratory research only; not for food, drug, or household use
Contact Information: Supplier or manufacturer emergency phone number and address listed on product packaging
Classification: Acute Toxicity (oral, dermal, inhalation), Eye Irritation, Specific Target Organ Toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed; toxic in contact with skin or if inhaled; causes serious eye irritation; may cause damage to organs through prolonged or repeated exposure
Pictograms: Skull and crossbones, exclamation mark, health hazard
Precautionary Statements: Avoid release to the environment; do not breathe dust, vapors, or mist; use in well-ventilated spaces; avoid skin and eye contact
NFPA Ratings: Health: 2; Flammability: 1; Reactivity: 0
Potential Health Effects: Can cause headache, drowsiness, nausea, respiratory tract irritation; repeated contact may damage the liver, kidneys, or blood system
Main Ingredient: 3-Nitroaniline
Concentration: >98%
Impurities/ Stabilizers: May contain trace aniline or nitrobenzene residues, depending on production source
Inhalation: Move affected person to fresh air; provide artificial respiration if necessary; seek medical attention immediately if symptoms develop
Skin Contact: Remove contaminated clothing and wash skin thoroughly with soap and water; seek medical attention if irritation persists
Eye Contact: Rinse eyes carefully with plenty of clean water for several minutes; lift eyelids occasionally; seek immediate medical care
Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel; provide water to dilute substance; get medical help promptly
Workplace Notes: Medical staff should be informed of the substance and shown product label; keep affected person under observation for delayed effects
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Media: Direct water jet may spread fire
Specific Fire Hazards: Material may decompose emitting toxic fumes of nitrogen oxides, carbon monoxide, and aniline vapors
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective suit
Special Procedures: Remove containers from fire area if safe; dike runoff to prevent environmental contamination
Explosion Potential: Dust may form explosive mixtures with air in closed spaces
Personal Precautions: Avoid contact with skin and eyes; wear appropriate personal protective gear including gloves, goggles, and respirator
Environmental Precautions: Prevent release to waterways and soil; notify authorities if significant spill occurs
Cleanup Methods: Collect spilled material with inert absorbent (sand, earth), shovel into safe container for disposal; ventilate area; wash residue with plenty of water
Decontamination: Avoid dust generation; use wet methods when cleaning up dry powders to prevent airborne particles
Handling: Use only with local exhaust ventilation or in chemical fume hood; keep away from heat, sparks, and open flame; avoid creating airborne dust
Hygiene Measures: Do not eat, drink, or smoke when using product; wash hands before breaks and at end of shift; take off contaminated clothing before entering eating areas
Storage: Store in tightly closed containers in cool, dry, well-ventilated place; protect from direct sunlight; store away from strong oxidizers, reducing agents, and acids
Incompatibilities: Avoid storing with mineral acids, strong bases, organic peroxides, and combustible materials
Packaging: Use glass, polyethylene, or sealed metal containers; avoid prolonged storage in plastic bags
Occupational Exposure Limits: No established OSHA or ACGIH limits; recommend following best laboratory safety practices
Engineering Controls: Chemical fume hood or local exhaust ventilation
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), splash goggles, lab coat
Respiratory Protection: Wear NIOSH-approved respirator if dusts, mists, or vapors are generated above recommended levels
Environmental Controls: Do not allow material to enter drains, surface water, or soil
Workspace Practices: Wash hands and face before breaks and after handling chemicals
Appearance: Pale yellow to light brown crystalline solid
Odor: Faint aromatic or amine-like smell
Melting Point: 114-116°C
Boiling Point: 332°C
Flash Point: 199°C
Autoignition Temperature: 560°C
Solubility: Slightly soluble in water, soluble in alcohol and ether
Density: 1.47 g/cm³ at 20°C
Vapor Pressure: Negligible at ambient temperatures
pH: Not applicable
Partition Coefficient (log Kow): 1.24
Evaporation Rate: Very slow under normal conditions
Explosive Properties: Can form combustible dust concentrations in air
Chemical Stability: Stable under recommended storage conditions
Thermal Decomposition: Produces toxic fumes of nitrogen oxides and possibly aniline at high temperatures
Hazardous Reactions: Reacts strongly with oxidizing agents and strong acids; can decompose violently under reducing conditions
Conditions to Avoid: Open flames, high temperatures, humidity, sources of ignition
Materials to Avoid: Strong acids, strong bases, oxidizers, reducing agents; organic peroxides
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, aniline vapor
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral (rat) LD50: approx. 500 mg/kg; Dermal (rabbit) LD50: approx. 1500 mg/kg
Skin/Eye Contact: Can cause irritation, redness, and pain
Inhalation Effects: Can result in headache, dizziness, nausea, respiratory irritation; methemoglobinemia in severe cases
Ingestion Effects: Abdominal pain, vomiting, drowsiness, risk of systemic toxicity
Chronic Effects: Repeated exposure may damage blood, liver, kidneys; possible risk of cyanosis due to interference with oxygen transport
Carcinogenicity: Not classified as carcinogenic to humans by IARC, NTP, or OSHA
Sensitization: Not known to cause allergic reactions on skin or respiratory tract
Mutagenicity / Reproductive Toxicity: Limited data; no significant reproductive or genotoxic effects reported
Ecotoxicity: Harmful to aquatic organisms; 96-hr LC50 (fish): 3-6 mg/L
Persistence and Degradability: Not readily biodegradable; may persist in environment and contaminate water, sediment, and soil
Bioaccumulation Potential: Moderate; log Kow suggests possible accumulation in aquatic organisms
Mobility in Soil: Low to moderate depending on environmental pH and organic content
Other Adverse Effects: May interfere with natural microbial activity; avoid accidental discharge to waterways
Waste Disposal Methods: Should be disposed of in accordance with local, regional, national, and international regulations; treat as hazardous chemical waste
Disposal Containers: Collect in sealed, clearly labeled, chemical-resistant containers
Incineration: Incinerate only at licensed facility equipped for chemical waste
Sewage Disposal: Avoid release to sewers or other water systems
Empty Packaging: Triple rinse containers before disposal or recycle according to local regulations
UN Number: UN 1661
UN Proper Shipping Name: Nitroaniline, solid
Transport Hazard Class: 6.1 (Toxic substance)
Packing Group: III
Labels Required: Toxic (skull and crossbones symbol)
Environmental Hazards: Marine pollutant (as per special provisions); avoid accidental spillage
Special Precautions: Keep tightly sealed and upright; prevent package breakage during transport; segregate from foodstuffs and incompatible chemicals
Transport Regulations: Comply with international, national, and regional transport legislation (USA DOT, IATA, IMDG codes)
TSCA Status: Listed
DSL/NDSL (Canada): Listed
OSHA Hazards: Toxic by ingestion, skin contact, and inhalation
SARA 313 (Toxic Release Inventory): Subject to reporting requirements
California Prop 65: Not listed as known to cause cancer or reproductive toxicity
REACH (EU): Subject to registration and restrictions
Other Local Legislation: May require notification or licensing in specific jurisdictions; always refer to country-specific laws and workplace guidance
