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Substance Name: 3-Nitro-4-Toluidine
Synonyms: 4-Amino-3-nitrotoluene
CAS Number: 89-62-3
Recommended Use: Used in dyes, pigments, and organic synthesis
Manufacturer Contact: Emergency phone and supplier details must appear on the label
Address: Manufacturer’s registered workplace, city, country
Email: Safety support contact
GHS Classification: Acute toxicity (oral, dermal, inhalation) – Category 4; Skin irritation – Category 2; Eye irritation – Category 2A; Aquatic Chronic toxicity – Category 3
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes skin and eye irritation; Suspected of causing cancer; May cause damage to organs through prolonged or repeated exposure; Harmful to aquatic life with long lasting effects
Precautionary Statements: Avoid breathing dust; Wash thoroughly after handling; Do not eat, drink, or smoke when using; Wear protective gloves, clothing, eye protection
Chemical Name: 3-Nitro-4-Toluidine
Common Synonyms: 4-Methyl-3-nitroaniline
Chemical Formula: C7H8N2O2
Molecular Weight: 152.15 g/mol
Ingredient Purity: ≥98%
Impurities: Typically less than 2% related organics or process residues
Other Components: No significant stabilizers or additives included
Inhalation: Move victim to fresh air, keep at rest in a position comfortable for breathing, seek medical help if symptoms develop
Skin Contact: Remove contaminated clothing, wash skin with plenty of water and soap, do not use solvents, seek medical attention for irritation or persistent symptoms
Eye Contact: Rinse with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical help if irritation persists
Ingestion: Rinse mouth, do not induce vomiting, provide water if victim is alert, seek immediate medical advice
Most Important Symptoms: Respiratory irritation, skin rash, dizziness, nausea; medical observation required due to possible delayed effects
Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide, do not use water jet
Special Hazards: Emits toxic fumes of nitrogen oxides and carbon monoxide if burned
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full body protective suit
Advice for Firefighters: Use water spray to keep containers cool, avoid breathing smoke or combustion products, isolate area and ventilate
Personal Precautions: Wear chemical-resistant gloves, goggles, and protective clothing; use a respirator in case of dust formation
Environmental Precautions: Prevent runoff to drains or water sources, inform environmental authorities if contamination occurs
Cleanup Methods: Sweep up carefully, avoid dust creation, place material in clearly labeled containers, ventilate contaminated area, dispose as hazardous waste
Decontamination: Wash affected surface with water and mild detergent after removal
Safe Handling: Use only in a well-ventilated area; keep away from food and beverages; avoid inhalation, ingestion, and skin contact; wear proper PPE; ensure emergency showers and eyewash stations are nearby
Storage Conditions: Store in original tightly sealed containers at room temperature in dry, cool, well-ventilated, and lockable locations, away from incompatible substances such as strong oxidizers and acids; avoid exposure to direct sunlight and heat sources
Specific End Use: Used in laboratory, research, and industrial synthesis with restricted access for trained users
Occupational Exposure Limits: No specific national OELs established; minimize exposure as much as possible using available methods
Engineering Controls: Local exhaust ventilation, general room ventilation, closed system operations where possible
Respiratory Protection: NIOSH/MSHA-approved respirator for dusts and organic chemicals
Skin Protection: Chemical-resistant gloves (nitrile, neoprene), protective clothing including lab coat or coverall
Eye Protection: Safety goggles or face shield
Hygiene Measures: Wash hands after handling; no eating, drinking, or smoking in work area; regular maintenance and inspection of PPE
Appearance: Pale yellow to orange-brown solid, crystalline powder
Odor: Faint aromatic odor
Odor Threshold: Not determined
pH Value: Not applicable (insoluble in water)
Melting Point: 115–119 °C
Boiling Point: Decomposes before boiling
Flash Point: 151 °C (open cup)
Evaporation Rate: Not determined
Flammability: Not classified as highly flammable, can burn at high temperatures
Vapor Pressure: Negligible at ambient temperature
Solubility: Sparingly soluble in water; soluble in alcohol and hot organic solvents
Partition Coefficient (log Kow): 2.16 (estimated)
Vapor Density: Not determined
Viscosity: Not applicable
Auto-Ignition Temperature: Not determined
Explosive Properties: Not explosive
Oxidizing Properties: Not classified as oxidizing
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not reactive under normal use
Hazardous Reactions: None known under normal use
Conditions to Avoid: Excessive heat, open flames, and incompatible materials
Incompatible Materials: Strong oxidizers, strong acids, reducing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, and possibly toxic aromatic compounds during decomposition or combustion
Acute Toxicity: Harmful if swallowed, inhaled, or absorbed through the skin; LD50 oral (rat): 390 mg/kg
Skin Corrosion/Irritation: Causes moderate skin irritation on contact
Serious Eye Damage/Irritation: Produces eye irritation
Respiratory Sensitization: May cause respiratory irritation
Skin Sensitization: Not classified as sensitizing by available data
Carcinogenicity: Suspected human carcinogen by analogy to related nitroanilines
Mutagenicity: No mutagenic effects observed in standard tests
Reproductive Toxicity: Data insufficient, reproductive effects not established
Repeated Dose Toxicity: Prolonged exposure may damage organs such as the liver, kidneys, or blood system
Symptoms of Exposure: Drowsiness, headache, cyanosis, methemoglobinemia with prolonged or high exposure
Aquatic Toxicity: Harmful to aquatic organisms; EC50 (Daphnia magna): 19 mg/L (48 hours)
Persistence and Degradability: Moderately persistent, not readily biodegradable
Bioaccumulative Potential: Potential for bioaccumulation in aquatic organisms due to moderate log Kow
Mobility in Soil: Low mobility, tends to adsorb to soils and sediments
Other Adverse Effects: May cause long-term hazards in the environment, avoid uncontrolled release
Waste Disposal Methods: Incinerate in a chemical waste facility equipped for nitrogen compounds or handle as hazardous waste with an approved contractor
Contaminated Packaging: Dispose of packaging as hazardous waste, ensure containers are completely emptied before final disposal
Environmental Precautions: Prevent waste from entering surface or ground water, drains, or sewers
Disposal Codes: Follow local, national, and international regulations for hazardous waste
UN Number: 1661
UN Proper Shipping Name: Nitroaniline compounds, solid
Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Yes (marked as a Marine Pollutant if shipped by sea)
Special Precautions: Avoid spillage, use sealed containers, secure all packaging during transport
Transport Labels: Toxic, Environmentally hazardous
Safety, Health, and Environmental Regulations: Covered under global chemical inventories such as TSCA (US), REACH (EU), DSL (Canada), ENCS (Japan)
Labeling: Clearly labeled as hazardous, with risk and safety phrases per regional regulation
Workplace Controls: Subject to local occupational exposure controls; employers must provide safety training and MSDS access
Restrictions: Restricted for use by qualified personnel, may require reporting or special permits depending on jurisdiction
Other Notes: Subject to international shipping and storage regulations due to classification as a toxic solid
