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Product Name: 3-Nitro-4-Hydroxybenzenearsonic Acid
Synonyms: Roxarsone, 4-Hydroxy-3-nitrophenylarsenic acid
CAS Number: 121-19-7
Recommended Use: Laboratory reagent, research chemical
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Classification: Acute Toxicity (Oral), Acute Toxicity (Dermal), Acute Toxicity (Inhalation), Skin Irritation, Serious Eye Damage, Carcinogenicity, Aquatic Chronic Hazard
GHS Label Elements: Pictograms: Skull and crossbones, Exclamation mark, Corrosive, Environment
Signal Word: Danger
Hazard Statements: Toxic if swallowed or inhaled, Harmful in contact with skin, Causes serious eye damage, May cause cancer, Toxic to aquatic life with long-lasting effects
Precautionary Statements: Do not breathe dust or spray, Wear protective gloves, eye protection, and face protection, Wash skin thoroughly after handling, Do not eat, drink, or smoke when using, Avoid release to the environment
Known Symptoms: Nausea, vomiting, abdominal pain, skin irritation, eye damage, respiratory distress
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Chemical Name: 3-Nitro-4-Hydroxybenzenearsonic Acid
CAS No. 121-19-7
Formula: C6H6AsNO6
Molecular Weight: 263.04 g/mol
Component: 3-Nitro-4-Hydroxybenzenearsonic Acid, >99% by weight
Impurities: None known or present in negligible amounts
General Advice: Seek medical attention immediately for all exposures
Inhalation: Move victim to fresh air, provide oxygen if breathing is difficult, monitor for respiratory distress
Skin Contact: Remove contaminated clothing, wash affected area thoroughly with soap and water, seek medical advice if irritation persists
Eye Contact: Rinse cautiously with clean water for at least 15 minutes, keep eyelids open, contact an ophthalmologist
Ingestion: Rinse mouth with water, do not induce vomiting, provide water to drink only if conscious, urgent medical treatment required
Main Symptoms and Effects: Gastrointestinal discomfort, severe skin/eye irritation, coughing, shortness of breath, headache
Medical Attention: Immediate observation recommended, treat symptomatically
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: None identified for this material
Specific Hazards: Toxic fumes of arsenic oxides, nitrogen oxides may be released from combustion
Protective Equipment: Self-contained breathing apparatus (SCBA), full protective firefighting clothing
Firefighting Instructions: Keep containers cool with water spray, avoid runoff entering waterways, remain upwind, evacuate non-emergency personnel
Explosion Hazards: Dust may form explosive mixtures with air under certain conditions
Personal Precautions: Evacuate area, ensure proper ventilation, use personal protective equipment including respirator, gloves, and goggles
Environmental Precautions: Prevent spillage from entering drains, surface waters, or soil
Containment: Collect spillage using non-sparking tools, avoid creating dust, absorb residues with inert material (sand, vermiculite)
Clean-up Procedures: Place in suitable, labeled chemical waste containers, dispose of via approved hazardous waste facility
Decontamination: Thoroughly wash spill site and affected equipment after cleanup
Handling: Avoid handling without appropriate safety measures, minimize dust generation, use only in a chemical fume hood, avoid breathing vapors or mists
Hygiene Measures: Wash hands thoroughly after use, avoid eating or drinking around this material, remove contaminated clothing before leaving work area
Storage Requirements: Keep in tightly closed original container, store in a cool, dry, well-ventilated area away from food, incompatible materials (strong oxidizers, reducing agents, bases)
Incompatibilities: Alkalis, strong oxidizers, reducing agents
Storage Class: Toxic solid, hazardous to water
Control Parameters: Occupational Exposure Limits: ACGIH TLV (as As): 0.01 mg/m³, OSHA PEL (as As): 0.01 mg/m³
Engineering Controls: Local exhaust ventilation, use of glove box or fume hood when handling powder or solutions
Respiratory Protection: NIOSH-approved respirator for arsenic compounds, especially if airborne concentrations exceed exposure limits
Skin Protection: Use chemical-resistant gloves (nitrile, neoprene), full laboratory coat
Eye/Face Protection: Chemical safety goggles, face shield if risk of splashing or dust
Other Protective Measures: Use appropriate footwear, avoid skin contact, have eye-wash stations and safety showers available
Appearance: Yellow to light brown crystalline powder
Odor: Odorless
Melting Point: Decomposes above 190°C
Boiling Point: Not determined
Solubility: Slightly soluble in cold water, more soluble in hot water
pH: Not determined for solid; solution is acidic
Vapor Pressure: Negligible at room temperature
Density: ~1.7 g/cm³
Partition Coefficient (n-octanol/water): Not available
Flash Point: Not applicable
Auto-ignition Temperature: No data
Explosion Limits: Not available
Evaporation Rate: Not applicable
Viscosity: Not applicable (solid)
Chemical Stability: Stable under standard conditions, degrades under prolonged exposure to moisture, heat, light
Conditions to Avoid: High temperature, moisture, incompatible materials
Hazardous Reactions: Reacts with oxidizing agents, strong bases, and acids producing toxic gas
Incompatible Materials: Strong oxidizers, strong acids, alkalis
Decomposition Products: Toxic arsenic oxides, nitrogen oxides, carbon oxides
Polymerization: Will not occur under normal laboratory conditions
Likely Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Toxicity: LD50 (oral, rat): Approx. 100-200 mg/kg; data suggests high acute toxicity
Chronic Effects: Long-term exposure linked to skin, respiratory, cardiovascular, and neurological toxicity
Carcinogenicity: IARC: Group 1 (Carcinogenic to humans - for arsenic compounds), NTP: Known to be human carcinogen
Mutagenicity: Evidence of genetic toxicity in laboratory animals
Reproductive Toxicity: Animal studies indicate risk of teratogenicity, impaired fertility
Symptoms of Exposure: Nausea, vomiting, diarrhea, abdominal cramps, skin rashes, eye irritation, headache, impaired hepatic/renal functions
Additional Data: Toxic effects may be delayed, repeated exposure increases risk of accumulation and chronic illness
Aquatic Toxicity: Very toxic to aquatic life, LC50 (fish): <1 mg/L
Persistence and Degradability: Not readily biodegradable, persistent in soil and sediments
Bioaccumulation: Strong potential to bioaccumulate in aquatic organisms
Mobility in Soil: Moderate to low mobility, absorbs to soil particles
Effects on the Environment: Arsenic compounds can disrupt aquatic ecosystems, toxic at low concentrations
Other Adverse Effects: Long-term ecological impact due to persistence, regulatory action in many countries restricts use and disposal
Waste Treatment Methods: Dispose as hazardous waste in accordance with federal, state, local, or national regulations
Disposal of Contaminated Packaging: Triple rinse containers, puncture, and send to licensed hazardous waste handler
Specific Disposal Instructions: Do not dispose to wastewater, sewers, or uncontrolled public landfills
Further Information: Seek advice of local environmental authorities, retain chemical identity labels
UN Number: UN1557
UN Proper Shipping Name: Arsenic compounds, solid, n.o.s. (3-Nitro-4-Hydroxybenzenearsonic acid)
Transport Hazard Class: 6.1 (Toxic Substance)
Packing Group: II
Environmental Hazard: Marine pollutant
Transport Labels: Toxic, Environmentally hazardous substance
Special Precautions: Transport only in secure, labeled containers, protect from physical damage, keep away from foodstuffs
Additional Regulations: Subject to national and international transport regulations (ADR, IMDG, IATA)
U.S. Regulations: TSCA: Listed, CERCLA Reportable Quantity: 1 lb, SARA Title III Section 313: Arsenic compounds regulated
International Regulations: Listed on EINECS/ELINCS (EU), WHMIS (Canada): Class D Division 1B (very toxic material), REACH: Subject to authorization and restriction
OSHA: Regulated as a hazardous substance
State Regulations: California Proposition 65: Listed as a chemical known to cause cancer and reproductive toxicity
Other Information: Subject to export and import controls, environmental emissions limits apply in many jurisdictions, restrictions on use in agriculture and animal feed
