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Name: 3-Methylpiperidine Chemical formula: C6H13N Synonyms: 3-Methylhexahydropyridine CAS Number: 626-58-4 Appearance: Colorless to pale yellow liquid, distinct ammonia-like odor Usage: Intermediate in organic synthesis, catalyst, specialty chemical production
GHS Classification: Flammable liquid (Category 3), Acute toxicity (Oral Category 3, Dermal Category 3, Inhalation Category 4), Skin corrosion/irritation (Category 1B) Signal Word: Danger Hazard Statements: Flammable liquid and vapor, Toxic if swallowed or in contact with skin, Causes severe skin burns and serious eye damage, Harmful if inhaled Main Risks: Severe burns to skin, risk of vapor inhalation, nausea, central nervous system effects Pictograms: Flame, skull and crossbones, corrosion, exclamation mark
Main ingredient: 3-Methylpiperidine (approx. 99% purity) Impurities: Trace levels of related piperidine compounds possible Formulation additives: None reported in standard lab settings
Inhalation: Remove to fresh air immediately; respiratory distress requires medical attention. Observe for coughing, shortness of breath, wheezing. Skin contact: Remove contaminated clothing, rinse affected area with running water for at least 15 minutes, seek prompt medical attention due to risk of chemical burns. Eye contact: Rinse cautiously with water for 15 minutes, hold eyelids apart, rapid response critical due to corrosivity. Ingestion: Rinse mouth if conscious, do not induce vomiting, immediate medical care needed. Notes for doctors: Treat symptomatically, monitor for respiratory distress, consider risk of delayed pulmonary issues and metabolic acidosis.
Suitable extinguishing media: Alcohol-resistant foam, dry chemical powder, carbon dioxide; water spray for cooling only Specific hazards: Vapors may form explosive mixtures with air, may release toxic nitrogen oxides, carbon monoxide during combustion Personal protective equipment: Full protective suit, self-contained breathing apparatus Advice for firefighters: Fight fire from a safe distance, use water spray to cool containers, avoid inhalation of fumes
Spill response: Evacuate area, ventilate space, eliminate ignition sources Personal protection: Chemical-resistant gloves, goggles, apron, respirator for vapor exposure Clean up: Absorb with inert material like sand or vermiculite, collect in suitable container, avoid direct contact Environmental precautions: Prevent entry into waterways, soil, sewers, report significant spills to local authorities
Handling tips: Use only in well-ventilated areas, avoid skin and eye contact, keep away from heat, flames, and static Storage requirements: Store in tightly closed container, cool, dry, and segregated from acids, oxidizers, and ignition sources Transfer advice: Ground and bond containers during transfer to prevent static buildup
Engineering Controls: Local exhaust ventilation, fume hoods, explosion-proof equipment Exposure limits: No established OSHA or ACGIH TLV; minimize exposure as much as possible Personal protection: Gloves made of nitrile or neoprene, splash-resistant goggles, laboratory coat, use of respirators where vapor concentration is significant Hygiene measures: Wash hands before eating, avoid drinking or smoking while handling, remove contaminated clothing immediately
Physical state: Liquid Color: Colorless to yellow Odor: Strong, amine-like Boiling point: Around 144°C Melting point: -27°C Flash point: Approx. 29°C (closed cup) Density: 0.85 g/cm³ Vapor pressure: Moderate at room temperature Miscibility: Soluble in alcohols, moderately soluble in water
Chemical stability: Stable under recommended conditions Reactivity: Violent reactions with oxidizers, acids, strong reducing agents possible Incompatible materials: Strong acids, oxidizing agents, acid chlorides, acid anhydrides Hazardous decomposition products: Nitrogen oxides, carbon oxides under fire or decomposition Conditions to avoid: Heat, open flame, sources of ignition, poor ventilation
Routes of exposure: Inhalation, ingestion, skin and eye contact Acute effects: Severe irritation of skin, eyes, mucous membranes; nausea, headache, drowsiness if inhaled Chronic toxicity: No long-term studies in humans, risk of dermatitis or sensitization from repeated contact LD50 (oral, rat): Approximately 200 mg/kg LD50 (dermal, rabbit): Data limited, but high toxicity expected based on similar amines Additional notes: Respiratory tract irritation and central nervous system depression possible with significant exposure
Aquatic toxicity: Toxic to aquatic organisms, risk of long-term effects in aquatic environment Mobility: Mobile in soil, may reach groundwater; volatile so potential for atmospheric release Persistence and degradability: May undergo slow biodegradation, but exact data limited Bioaccumulation: Unlikely to significantly bioaccumulate based on molecular size and solubility
Disposal method: Chemical incineration with proper emission controls preferred Avoid: Dumping in sewers, water systems, or landfill Container disposal: Rinse with compatible solvent, dispose of according to local hazardous waste regulations Legal requirements: Follow regional and national hazardous waste disposal laws
UN Number: UN2733 Proper shipping name: 3-Methylpiperidine Transport hazard class: 3 (Flammable liquid) Packing group: II Special transport advice: Use corrosion-resistant materials in transport containers, segregate from acids and oxidizers
Global regulations: Listed under various chemical safety frameworks (REACH, TSCA) Hazard statements required: Flammable, toxic, corrosive labeling, SDS provision to users Workplace controls: Subject to risk management plans, chemical hygiene standards in many jurisdictions Additional guidance: Training in chemical handling, emergency response planning, incident reporting protocols all play essential roles in risk mitigation for anyone involved with 3-Methylpiperidine
