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Material Safety Data Sheet (MSDS) for 3-Hydroxy Cephalosporin

Identification

Product Name: 3-Hydroxy Cephalosporin
Synonyms: Hydroxy-cephalosporin derivative
Chemical Family: Beta-lactam antibiotic
Recommended Use: Intermediate for pharmaceutical synthesis, antibiotic research
Supplier: Refer to manufacturer details on purchasing documentation
Emergency Contacts: Local emergency response team, Poison Control Center
Molecular Formula: C16H17N3O6S2 (may vary by derivative)
Molecular Weight: Approximately 427.5 g/mol
Product Code: As specified by supplier
CAS Number: Check with supplier for specific variant
Relevant Identified Uses: Research, chemical intermediate
Restrictions on Use: Restricted to trained personnel only

Hazard Identification

GHS Classification: Acute toxicity (oral, dermal, inhalation), Irritant
Pictogram: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause allergic skin reaction, risk of respiratory sensitization
Precautionary Statements: Avoid contact with skin, eyes, clothing; wash thoroughly after handling; use protective equipment
Routes of Exposure: Inhalation, skin contact, ingestion
Effects of Short-Term Exposure: Irritation, nausea, possible headache
Effects of Long-Term Exposure: Allergic reactions, possible respiratory sensitization
Potential Health Effects: Dermatitis, eye inflammation, asthma-like symptoms
Environmental Hazards: Not classified as hazardous to aquatic life, but release into water should be avoided

Composition / Information on Ingredients

Chemical Name: 3-Hydroxy Cephalosporin
Concentration: >95% (as active pharmaceutical ingredient)
Chemical Class: Beta-lactam antibiotic derivative
Impurities: Potential process impurities <1%
Stabilizers/Preservatives: None present in pure form
Additives: None intentionally added

First Aid Measures

Inhalation: Move to fresh air, monitor for respiratory distress, seek medical attention for persistent symptoms
Skin Contact: Remove contaminated clothing, wash skin with soap and water, seek medical advice if irritation persists
Eye Contact: Rinse immediately with plenty of water for up to 15 minutes, get prompt medical attention
Ingestion: Rinse mouth, do not induce vomiting, consult medical personnel
Most Important Symptoms/Effects: Allergic reactions, respiratory irritation, dermatological issues
Advice to Physician: Treat symptomatically, monitor for late-onset allergic reaction
Note to First Responders: Use gloves, eye protection; avoid contact with powder or solution

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: Strong water jet (may spread product)
Specific Hazards: Emits toxic fumes of sulfur oxides, nitrogen oxides, carbon oxides under combustion
Protective Equipment: Wear self-contained breathing apparatus and full turnout gear
Special Procedures: Move containers from fire area, avoid discharge into drains
Unusual Fire Hazards: Dust from solid form may form explosive mixtures with air
Decomposition Products: Hazardous gases including CO, CO2, NOx, SOx

Accidental Release Measures

Personal Precautions: Use gloves, lab coat, chemical goggles, respirator if dusting
Environmental Precautions: Prevent further leakage or spillage if safe to do so; keep out of sewers and waterways
Methods for Clean-Up: Sweep up without creating dust, place in suitable, labeled container for disposal; clean area with water and detergent
Secondary Containment: Use absorbent material if solution form
Waste Disposal: Dispose according to local regulations
Reporting Requirements: Inform responsible authorities in case of large releases

Handling and Storage

Precautions for Safe Handling: Handle in well-ventilated area, avoid contact with skin, eyes, clothing; do not breathe dust or vapors
Technical Measures: Use fume hood, local exhaust ventilation; handle with tools, not bare hands
Storage Conditions: Store in tightly closed container, dry, cool place at 2–8°C, away from incompatible substances
Incompatible Materials: Strong oxidizers, acids, bases
Storage Class: Pharmaceutical intermediates
Packaging Materials: Use original container; secondary containment recommended for larger volumes
Specific End Use(s): Laboratory and pharmaceutical use only

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established occupational exposure limits for this compound
Engineering Controls: Local exhaust ventilation; use of fume hood in laboratory spaces
Respiratory Protection: NIOSH-approved respirator if dust or aerosols may form
Eye Protection: Chemical safety goggles
Skin Protection: Lab coat, impervious gloves, closed shoes
Hygiene Measures: Wash hands before breaks and after handling; do not eat, drink, or smoke when handling
Environmental Controls: Avoid contaminating water, soil, and drains
Monitoring Procedures: Biological monitoring not routinely required

Physical and Chemical Properties

Appearance: White to off-white powder
Odor: No significant odor
Odor Threshold: Not determined
pH: Slightly acidic in aqueous solution
Melting Point: 190–214°C (varies by derivative)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not applicable (solid material)
Flammability: May burn but not readily ignitable
Explosive Limits: Not determined
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Solubility: Soluble in methanol, DMSO, slightly soluble in water
Partition Coefficient (n-octanol/water): Not established
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Decomposes at elevated temperature
Viscosity: Not applicable (solid)

Stability and Reactivity

Chemical Stability: Stable under normal conditions below 25°C, protected from moisture and light
Reactivity: No dangerous reactions known under normal handling
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon oxides
Conditions to Avoid: Excessive heat, open flames, damp storage, exposure to direct sunlight
Polymerization: Will not occur

Toxicological Information

Routes of Exposure: Skin, eyes, inhalation, ingestion
Acute Toxicity: Low to moderate toxicity, LD50 (oral, rat) not well defined, extrapolated from related cephalosporins
Skin Corrosion/Irritation: May cause irritation or redness on prolonged contact
Serious Eye Damage/Irritation: May cause eye irritation
Respiratory Sensitization: Possible risk of asthmatic response in sensitive individuals
Skin Sensitization: Has potential to elicit allergic skin reactions
Germ Cell Mutagenicity: No data available
Carcinogenicity: No classification as carcinogen based on available data
Reproductive Toxicity: No evidence of adverse reproductive effects from analogous compounds
Specific Target Organ Toxicity: Not expected at low exposure, repeated or high-level exposures may affect liver or kidneys
Symptoms of Overexposure: Allergic reaction, rash, bronchospasm, nausea, vomiting

Ecological Information

Ecotoxicity: Not considered toxic to aquatic organisms at environmental concentrations; avoid release
Persistence and Degradability: Readily biodegradable in environmental conditions
Bioaccumulative Potential: Low, based on chemical properties
Mobility in Soil: No data available; likely moderate mobility due to moderate water solubility
Other Adverse Effects: Not expected to contribute to environmental hazard in small-scale laboratory disposal
Aquatic Release: Avoid discharge to surface water or sanitary sewer

Disposal Considerations

Waste Treatment Methods: Incineration in a chemical incinerator with afterburner and scrubber
Product Disposal: Treat as hazardous pharmaceutical waste; follow local, regional, national regulations
Contaminated Packaging: Dispose of according to official regulations
Recommended Disposal Containers: Sealed, labeled containers
Environmental Precautions: Prevent contamination of water sources and soil
Unused Product: Return to licensed disposal contractor, do not landfill
Disposal Restrictions: Avoid open discarding in the environment, prevent aerosol generation

Transport Information

UN Number: Not regulated as a dangerous good for transport
UN Proper Shipping Name: Not classified as hazardous for transport
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Special Precautions: Keep container tightly closed and upright; protect from moisture and excessive heat
IMDG Marine Pollutant: No
ICAO/IATA Packing Instructions: Standard laboratory chemical-appropriate containers
Transport Labeling: No special labeling required
Handling During Transport: Avoid rough handling

Regulatory Information

International Inventory Status: Not listed on major chemical inventories as an active substance
Approvals and Authorizations: For research and development only; not approved for food, drug, cosmetic, or household use
OSHA Hazards: Irritant, sensitizer
US Federal Regulations: Not subject to SARA Title III, CERCLA, or RCRA controls
California Proposition 65: Not listed
WHMIS (Canada): Controlled product classification D2B—Toxic material causing other toxic effects
Labeling Requirements: Laboratory use only, handle as sensitizer and irritant
Other Regulatory Notes: Not classed as a controlled drug or precursor; may be subject to custom or shipping notification