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Name: 3-Fluorotoluene
Chemical Formula: C7H7F
Other Names: meta-Fluorotoluene
CAS Number: 352-70-7
Description: Colorless, flammable liquid with a noticeable aromatic odor.
Uses: Intermediate for pharmaceuticals, agrochemicals, chemical synthesis.
Physical Hazards: Highly flammable liquid and vapor; can ignite at room temperature; vapors create explosive mixtures with air.
Health Hazards: Causes skin and eye irritation upon direct contact; inhalation can lead to central nervous system symptoms like headache or dizziness; ingestion may cause digestive discomfort and toxicity.
Environmental Hazards: Harmful to aquatic life; potential for groundwater contamination if spilled or disposed without care.
GHS Classification: Flammable liquids (Category 2); Acute toxicity – Oral (Category 4); Skin irritation (Category 2); Eye irritation (Category 2A).
Main Component: 3-Fluorotoluene — ≥ 99% by weight
Chemical Family: Fluorinated aromatic hydrocarbons
Common Impurities: Trace toluene, other fluorotoluene isomers (usually below 1%)
Inhalation: Move to fresh air immediately; if breathing feels difficult, seek medical attention; symptoms like dizziness or nausea may develop even after short-term exposure.
Skin Contact: Remove contaminated clothing; wash thoroughly with soap and water; persistent irritation calls for healthcare evaluation.
Eye Contact: Rinse carefully with plenty of water for about 15 minutes; remove contact lenses if present; medical help recommended if discomfort continues.
Ingestion: Do not give anything by mouth to an unconscious person; rinse mouth with water, avoid inducing vomiting; get specific medical attention right away.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, alcohol-resistant foam; avoid using water except for small fires.
Specific Hazards: Releases dense, toxic fumes including hydrogen fluoride and carbon monoxide when burning; in enclosed spaces, vapors can travel and cause flashback.
Protective Equipment: Wear full firefighting gear with self-contained breathing apparatus; stay upwind, cool containers with water spray to prevent explosion.
Firefighting Precautions: Keep runoff out of sewers and waterways; if safe, remove containers from fire area.
Personal Precautions: Ventilate area to prevent vapor buildup; wear chemical-resistant gloves, goggles or face shield, and appropriate protective clothing.
Environmental Precautions: Contain spills quickly to keep them away from drains, soil, and natural waterways; small leaks can spread fast due to vapor volatility.
Methods for Clean-up: Absorb with inert material like sand or vermiculite; collect in sealed, labeled containers for disposal; wash area with large amounts of water afterwards.
Special Notes: Avoid contact with open flames or heat during cleanup; be careful not to breathe vapors or touch with bare skin.
Handling: Operate in well-ventilated spaces or use local exhaust; keep away from sparks, hot surfaces, and flames; avoid inhaling vapors and direct skin or eye contact.
Storage: Store in tightly closed containers, in a cool, dry, and correctly ventilated spot away from sources of heat and ignition; segregate from oxidizing agents and acids.
Transfer Considerations: Use grounded containers and tools to avoid creating static electricity.
Incompatibles: Strong oxidizers, acids, bases; store separately to prevent dangerous reactions.
Engineering Controls: Use fume hoods, explosion-proof equipment, and local exhaust ventilation; keep working concentrations low.
Personal Protective Equipment: Nitrile or neoprene gloves, chemical safety goggles or face shield, lab coat or apron, flame-resistant clothing; use a respirator if ventilation is inadequate or working in a confined space.
Exposure Limits: No nationwide occupational exposure limit set, but general toluene threshold values may offer a reference point for minimizing exposure.
State: Liquid
Appearance: Clear, colorless
Odor: Aromatic, sweet-smelling
Boiling Point: Around 138°C
Melting Point: −41°C
Flash Point: Between 29–32°C (closed cup)
Solubility: Insoluble in water; mixes well with common organic solvents
Vapor Pressure: Moderate at room temperature
Density: About 1.03 g/cm³ at 20°C
Partition Coefficient (Log Kow): Estimated 2.5–2.8
Stability: Remains stable in normal conditions with adequate ventilation and storage.
Reactivity: Reacts vigorously with strong oxidizers, acids, and bases.
Hazardous Decomposition: Burning releases hydrogen fluoride, carbon monoxide, carbon dioxide, and other toxic byproducts.
Polymerization: Not known to occur under ordinary circumstances.
Probable Routes of Exposure: Inhalation, skin contact, eye contact, ingestion.
Acute Effects: Short exposure can cause irritation of eyes, respiratory tract, and skin; inhalation may depress the central nervous system.
Chronic Effects: Prolonged or repeated exposure might lead to liver and kidney effects, headaches, or tiredness.
Carcinogenicity: No clear evidence of carcinogenic action in humans; related aromatic solvents raise questions over time.
Sensitization: Generally not considered a significant sensitizer to skin or respiratory tract.
Ecotoxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Breakdown in nature takes time; volatilizes readily but can linger in soils and groundwater.
Bioaccumulation: Could build up in fish and other organisms, especially where water is contaminated.
Mobility: Flows readily and evaporates quickly in air but adheres to organic content in soil.
Disposal Method: Send waste or unused product to certified chemical disposal facilities; do not pour down the drain; do not burn in open air or regular incinerators.
Contaminated Packaging: Rinse and triple-wash containers, then treat as hazardous waste according to local laws.
Environmental Protection: Never dispose in common trash or municipal landfills; always prevent leaks or spills during transport to disposal sites.
Regulatory Advice: Local and regional laws dictate disposal best practices; always check before discarding.
UN Number: Often classified under flammable liquids, UN 1993
Shipping Name: Flammable liquid, n.o.s. (contains 3-fluorotoluene)
Hazard Class: 3 (Flammable Liquids)
Packing Group: II
Labels: Flammable liquid labels required on packages
Transport Precautions: Keep tightly closed and upright; ground containers during transfer; segregate from incompatible goods during transport.
Global Regulations: Often not specifically regulated but covered under regulations for hazardous, flammable organics.
United States: Listed in TSCA inventory; workplace regulations may apply under OSHA for chemical hazards.
European Union: Covered by REACH as a hazardous substance; classified per CLP (Classification, Labelling and Packaging regulation).
Other Jurisdictions: Local chemical safety and workplace laws may set additional handling, storage, and reporting requirements; adapt protocols to regional standards.
