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Product Name: 3-Ethoxyaniline
Chemical Formula: C8H11NO
CAS Number: 536-66-3
Synonyms: m-Ethoxyaniline, 3-Ethoxybenzenamine
Recommended Use: Chemical synthesis, research, intermediate for organic compounds
Supplier: Refer to the label or purchase documentation for contact information
Emergency Contact: Refer to company’s emergency number or Poison Control
GHS Classification: Acute toxicity – Oral (Category 4); Acute toxicity – Dermal (Category 4); Eye irritation (Category 2A); Skin irritation (Category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, in contact with skin or inhaled; Causes skin irritation; Causes serious eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, fumes, gas, mist, vapors, spray; Wash skin thoroughly after handling; Use only outdoors or in a well-ventilated area; Wear protective gloves, eye protection, and face protection
Chemical Identity: 3-Ethoxyaniline
Common Name: 3-Ethoxyaniline
Concentration: ≥98% (commercial grade)
Impurities: <1% (varies with source), low levels of related anilines possible
EC Number: 208-639-4
Inhalation: Move to fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin with water for at least 15 minutes, seek medical advice for irritation or sores
Eye Contact: Rinse immediately with plenty of water for several minutes, remove contact lenses if present, continue rinsing, contact ophthalmologist
Ingestion: Rinse mouth, do not induce vomiting, give water to drink if conscious, seek immediate medical attention
Most Important Symptoms/Effects: Headache, nausea, respiratory discomfort, irritation of eyes and skin; prolonged exposure can cause methaemoglobinaemia
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Hazards: Emits toxic fumes under fire conditions (nitrogen oxides, carbon monoxide, carbon dioxide)
Special Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Advice for Firefighters: Keep containers cool with water spray, avoid runoff, evacuate area in case of large fire, prevent firewater contamination
Personal Precautions: Wear appropriate protective clothing, eye, and face protection, ensure adequate ventilation
Environmental Precautions: Prevent further leakage or spillage, do not let product enter drains or watercourses, inform authorities if significant spill occurs
Methods for Cleanup: Absorb with inert material (sand, earth, vermiculite), collect in suitable closed containers, wash spill site after material pickup, ventilate area
Special Instructions: Use non-sparking tools, avoid dust generation, monitor area for vapors
Handling: Avoid contact with skin, eyes, and clothing, use with adequate ventilation, do not inhale vapors or fumes, handle in a chemical fume hood
Storage: Keep container tightly closed in a cool, dry, and well-ventilated place, segregate from incompatible substances (strong oxidizers, acids), store away from food and animal feed
Incompatibilities: Strong acids, strong oxidizing agents, nitrosating agents
Occupational Exposure Limits: No specific limits established in most jurisdictions; minimize exposure to the lowest feasible level
Engineering Controls: Use local exhaust ventilation, eye wash stations, safety showers
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), splash goggles, lab coat or apron, appropriate respirator if ventilation inadequate
Hygiene Measures: Remove contaminated clothing, wash hands after handling, do not eat, drink, or smoke near the product, launder clothing before reuse
Appearance: Clear to slightly yellow liquid
Odor: Aromatic, amine-like
Boiling Point: 221–223 °C
Melting Point: -6 °C
Flash Point: 108 °C (closed cup)
Autoignition Temperature: 455 °C
Vapor Pressure: 0.04 mmHg @ 25 °C
Solubility: Soluble in organic solvents (ethanol, ether), sparingly soluble in water
Density: 1.034 g/cm³ @ 25 °C
pH: Not applicable (non-aqueous solution)
Partition Coefficient (log Pow): ~1.5 (estimated)
Viscosity: Not determined
Chemical Stability: Stable under recommended storage conditions
Hazardous Reactions: May react with strong oxidizing agents, acids, and nitrosating agents
Decomposition Products: Emits toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide under severe heating
Polymerization: Not expected under normal conditions
Conditions to Avoid: Heat, flames, strong light, incompatible materials
Acute Toxicity: LD50 (oral, rat): ~750 mg/kg; LD50 (dermal, rabbit): ~1,210 mg/kg
Inhalation: Harmful if inhaled, may cause respiratory irritation
Skin Corrosion/Irritation: Causes moderate irritation, risk of dermatitis with prolonged contact
Eye Damage/Irritation: Causes significant eye irritation
Chronic Effects: Prolonged exposure may affect blood (methaemoglobinaemia), CNS, liver, kidneys
Carcinogenicity: Not classified as carcinogenic by OSHA, IARC, or NTP
Mutagenicity: No adequate data available
Reproductive Toxicity: Data insufficient
Ecotoxicity: Toxic to aquatic organisms (fish LC50 [96hr] estimated at 10–50 mg/L)
Persistence and Degradability: Limited information; expected to degrade slowly in environment
Bioaccumulation: Potential for moderate bioaccumulation
Mobility: Limited mobility in soil; moderately volatile
Other Information: May cause long-term effects in aquatic environment, do not discharge into drains or surface waters
Disposal Methods: Dispose of as hazardous waste according to local, regional, national, and international regulations
Contaminated Packaging: Rinse with suitable solvent, dispose as hazardous material
Waste Codes: Consult local regulations for specific disposal requirements
Special Precautions: Do not release to the environment, avoid landfill if possible
UN Number: 2273
UN Proper Shipping Name: 3-Ethoxyaniline
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Marine Pollutant: No data
Special Precautions: Keep away from incompatible materials, transport separately from foodstuffs
Shipping Labels: Toxic substance (skull and crossbones symbol)
OSHA Status: Hazardous
TSCA Inventory: Listed
EINECS: 208-639-4
REACH Status: Exempted under Art 2(7)(a), otherwise handle as hazardous
SARA Title III - Section 313: Not subject to reporting
California Proposition 65: Not listed
WHMIS Classification: Toxic Material, D1B (immediate and serious toxic effects); skin/eye irritant
Other National/International Regulations: May be subject to various chemical control laws globally; always check current national legislation
