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Product Name: 3-Bromopropyne
Chemical Formula: C3H3Br
Synonyms: Propargyl bromide, 1-bromo-2-propyne
Company Identification: Manufacturer name and emergency contact supplied on request
CAS Number: 106-96-7
Recommended Use: Laboratory chemicals, synthesis intermediate
Not intended for: Food, drug, cosmetic, or household use
GHS Classification: Acute toxicity (oral, dermal, inhalation): Category 2; Skin corrosion/irritation: Category 1B; Eye damage/irritation: Category 1; Specific target organ toxicity (single exposure): Category 3
Signal Word: Danger
Hazard Statements: Fatal if swallowed, in contact with skin, or if inhaled. Causes severe skin burns and eye damage. May cause respiratory irritation.
Pictograms: Skull and crossbones, Corrosion, Exclamation mark
Precautionary Statements: Do not breathe dust, fume, gas, mist, vapors, or spray. Wash hands and face thoroughly after handling. Use only outdoors or in a well-ventilated area. Wear protective gloves, clothing, and eye and face protection.
Route of Exposure: Inhalation, skin contact, eye contact, ingestion
Chemical Name: 3-Bromopropyne
Synonyms: Propargyl bromide
Concentration: 99% or greater
CAS Number: 106-96-7
Impurities/Additives: Trace organics possible; not expected to alter hazard classification
Inhalation: Remove person to fresh air. Seek immediate medical attention. If breathing stops, administer artificial respiration and use oxygen if trained.
Skin Contact: Remove contaminated clothing. Immediately rinse skin with plenty of water for at least 15 minutes. Get medical attention right away.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing, seek urgent medical advice.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting. Get immediate medical help.
Most important symptoms and effects: Severe burns, difficulty breathing, intense pain at contact site, dizziness, loss of consciousness
Protective equipment for first responders: Self-contained breathing apparatus, chemical protective clothing
Suitable Extinguishing Media: Dry chemical, carbon dioxide, or foam. Use water spray only to cool containers.
Unsuitable Extinguishing Media: Direct water stream may cause chemical to spread.
Specific Hazards: Toxic gases such as hydrogen bromide, carbon monoxide, and carbon dioxide may form under fire conditions.
Special Protective Equipment: Wear self-contained breathing apparatus and full protective suit.
Other Information: Remove containers from fire area if this can be done without risk. Contain and collect contaminated water for disposal.
Personal Precautions: Prevent inhalation, skin and eye contact by using personal protective equipment. Remove all sources of ignition.
Environmental Precautions: Do not allow to enter drains, surface or groundwater.
Cleanup Methods: Ventilate area. Use inert absorbent material, such as dry earth or sand, to contain leak or spill. Scoop up and place in a suitable, tightly closed chemical waste container for proper disposal. Decontaminate spill area with sodium bisulfite or sodium thiosulfate solution; rinse with water.
Preventive Actions: Evacuate non-essential personnel, ensure proper ventilation, and monitor vapor levels if possible.
Precautions for Safe Handling: Avoid breathing vapors or contact with eyes, skin, or clothing. Use fume hood, ensure immediate access to emergency eyewash and shower.
Storage Conditions: Store in a tightly closed, properly labeled container in a cool, dry, well-ventilated place. Keep away from sunlight, heat sources, strong oxidizers, and acids.
Incompatible Materials: Strong bases, strong oxidizing agents, sources of ignition, acids
Safe Transfer Procedures: Ground and bond containers when transferring. Use non-sparking tools.
Exposure Limits: No occupational exposure limits established by OSHA, ACGIH, or NIOSH as of review date.
Engineering Controls: Use local exhaust ventilation, fume hood, proper chemical storage.
Personal Protective Equipment: Chemical splash goggles, face shield, impervious gloves (e.g., butyl rubber or nitrile), flame-retardant lab coat, full body suit for significant spills.
Respiratory Protection: NIOSH/MSHA-approved air-purifying respirator for organic vapors or self-contained breathing apparatus for high vapor areas or spill response.
Hygiene Measures: Wash hands, face, and contaminated clothing thoroughly after handling. Do not eat, drink, or smoke in work areas.
Appearance: Colorless to pale yellow liquid
Odor: Pungent, acrid
Odor Threshold: Not established
pH: Not applicable
Melting Point: −80°C
Boiling Point: 89–91°C
Flash Point: 14°C (closed cup)
Evaporation Rate: Data not available
Flammability: Flammable liquid
Explosion Limits: Lower: 2.1% vol, Upper: data not available
Vapor Pressure: 38 mmHg @ 25°C
Vapor Density: 3.9 (air = 1)
Relative Density: 1.5 (water = 1)
Solubility: Slightly soluble in water; miscible with common organic solvents
Partition coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: 375°C
Decomposition Temperature: Not determined
Viscosity: Not available
Chemical Stability: Stable under recommended storage conditions. Unstable at elevated temperatures, in presence of moisture, and exposure to light.
Conditions to Avoid: Heat, flames, sparks, direct sunlight, contact with air and moisture
Substances to Avoid: Strong oxidizing agents, strong bases and acids, reducing agents
Hazardous Decomposition: Hydrogen bromide, carbon oxides, corrosive and toxic fumes
Polymerization: May occur under improper storage conditions, violent with incompatible substances
Acute Toxicity: Oral (rat) LD50: 23 mg/kg. Dermal (rabbit) LD50: 210 mg/kg. Inhalation (rat) LC50: 27 ppm/4h
Corrosivity: Causes severe burns to skin and eyes.
Inhalation: Highly toxic, symptoms include cough, shortness of breath, headache, nausea, pulmonary edema, and respiratory failure with high exposure.
Skin/Eye Contact: Causes blistering, burning, redness, pain, permanent tissue damage possible.
Ingestion: Symptoms include abdominal pain, vomiting, diarrhea, chemical burns to mouth, throat, and stomach.
Sensitization: Not known to cause skin or respiratory sensitization.
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA.
Reproductive Toxicity: Data insufficient for classification
Additional Information: Repeated exposure may cause organ damage, especially to liver, kidneys, and central nervous system.
Ecotoxicity: Very toxic to aquatic organisms. May cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Not readily biodegradable.
Bioaccumulation Potential: No significant bioaccumulation expected due to low water solubility.
Mobility in Soil: Expected to be mobile; may contaminate groundwater.
Other Adverse Effects: Releases to the environment must be avoided; hazardous to flora and fauna in spills.
Environmental Fate: Breaks down slowly under environmental conditions, especially in absence of oxygen.
Waste Treatment Methods: Dispose of contents and container in accordance with local, state, and federal regulations. Consult licensed hazardous waste disposal contractor.
Container Handling: Do not reuse container; triple rinse and offer for recycling if approved.
Additional Advice: Do not dump into drains or waterways. Incinerate at a properly permitted facility with appropriate emission controls.
Large Quantities: Coordinate with hazardous waste management for collection and destruction.
UN Number: UN2345
Proper Shipping Name: 3-Bromopropyne
Hazard Class: 6.1 (Toxic), 3 (Flammable liquid)
Packing Group: I
Label: Toxic, flammable liquid
Marine Pollutant: Yes
Special Precautions: Keep away from heat, sparks, open flames. Ensure containers remain upright and secure during transit.
Additional Transport Notes: Emergency response guidebook reference 151
TSCA: Listed on the US Toxic Substances Control Act inventory
SARA Title III: Listed under Sections 302, 304, 313 as extremely hazardous substance
OSHA: Classified hazardous per OSHA Hazard Communication Standard
REACH (Europe): Subject to restrictions on manufacture and use
WHMIS (Canada): Controlled product, Class D1A, D1B, B2
California Proposition 65: Not listed
Other Regulations: Subject to stringent workplace exposure and environmental release controls in multiple jurisdictions, due to high acute toxicity and environmental hazard profile
