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Material Safety Data Sheet: 3-Bromopropionyl Bromide

Identification

Product Name: 3-Bromopropionyl Bromide
Chemical Formula: C3H4Br2O
Synonyms: Propanoyl bromide, 3-bromo-, 3-Bromopropanoic acid bromide
CAS Number: 818-70-4
Recommended Use: Laboratory chemicals, industrial research, organic synthesis
Manufacturer Information: [Insert accurate contact details for producer or supplier here]
Emergency Contact Number: [Insert 24-hour emergency number here]

Hazard Identification

Classification: Corrosive, toxic, harmful if inhaled or exposed to skin, causes severe burns and serious eye damage, irritant to respiratory system
GHS Label Elements:
Pictograms: Corrosive, toxic, environmental
Signal Word: Danger
Hazard Statements: Causes severe skin and eye burns, toxic if inhaled, may cause respiratory irritation, harmful to aquatic life, possible tissue destruction upon contact
Precautionary Statements: Avoid breathing dust or vapor, wear protective clothing, use only in well-ventilated areas, avoid release to the environment, wash hands after handling

Composition / Information on Ingredients

Substance: 3-Bromopropionyl Bromide
Chemical Purity: ≥98%
Chemical Formula: C3H4Br2O
Molecular Weight: 231.87 g/mol
Impurities: Potential halo acid contaminants, residual solvents from manufacture

First Aid Measures

General Advice: Move exposed individual to fresh air, remove contaminated clothing, seek immediate medical attention
Inhalation: Remove to fresh air, monitor breathing and provide oxygen as required, consult a doctor right away
Skin Contact: Rinse with plenty of water for at least 15 minutes, remove contaminated clothing and shoes, seek medical attention for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing for a minimum of 15 minutes, get immediate medical attention
Ingestion: Do not induce vomiting, rinse mouth thoroughly, seek medical attention immediately, never give anything by mouth to an unconscious person

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Special Hazards: May emit hydrogen bromide, carbon monoxide, carbon dioxide, and corrosive vapors when heated
Fire Fighting Instructions: Wear full protective gear including positive pressure self-contained breathing apparatus
Protective Measures: Cool containers exposed to fire with water spray, avoid inhalation of dangerous decomposition products
Explosion Hazard: Non-flammable, but reacts violently with water to produce corrosive fumes

Accidental Release Measures

Personal Precautions: Wear chemical splash goggles, gloves, respirator, and full protective clothing
Environmental Precautions: Prevent further leakage or spillage if safe, contain run-off, avoid release into sewers and watercourses
Spill Cleanup Methods: Ventilate area, neutralize spills with sodium bicarbonate or lime, absorb residue with inert material such as sand or vermiculite, place in labeled container for disposal
Notification Procedures: Notify government or environmental authorities if release moves outside facility boundaries

Handling and Storage

Safe Handling: Use only in fume hood, avoid all bodily contact, never breathe vapors or allow skin contact, keep away from sources of ignition
Personal Protection: Wear impervious gloves, protective goggles, chemical apron, face shield as required
Safe Storage: Keep container tightly sealed in cool, dry, well-ventilated area, store away from water, alcohols, oxidizing agents, bases
Incompatible Materials: Strong bases, water, alcohols, oxidizers, moisture sensitive chemicals
Storage Temperature: Store at 2-8°C, do not freeze, avoid excessive heat

Exposure Controls and Personal Protection

Occupational Exposure Limits: No data from ACGIH, OSHA; minimize exposure as much as possible using engineering controls
Engineering Controls: Fume hood recommended, local exhaust ventilation, minimize vapor accumulation
Hand Protection: Butyl rubber or nitrile chemical-resistant gloves
Eye Protection: Chemical splash goggles, face protection
Skin Protection: Chemical-resistant lab coat, apron, long sleeves
Respiratory Protection: NIOSH/MSHA-approved respirator for vapors above permissible limits
Hygiene Measures: Wash hands thoroughly after handling, no eating or drinking in work area

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Sharp, acrid, pungent
Odor Threshold: No data available
pH: Not applicable
Melting Point: No data, probably below room temperature
Boiling Point: 100-102°C
Flash Point: Not determined
Evaporation Rate: No data
Flammability: Not flammable
Explosion Limits: Not available
Vapor Pressure: No data
Vapor Density: No data
Relative Density: 2.02 g/cm³ at 20°C
Solubility: Decomposes in water, soluble in organic solvents
Partition Coefficient: Not determined
Auto-ignition Temperature: No data
Decomposition Temperature: May decompose above boiling

Stability and Reactivity

Chemical Stability: Stable if stored correctly in original, sealed container
Reactivity: Reacts with water, alcohols, bases with rapid hydrolysis, releases hydrogen bromide fumes
Hazardous Reactions: Violent reaction with water or alcohol, possible explosion with alkali metals
Hazardous Decomposition: Hydrogen bromide, toxic, corrosive gases
Conditions to Avoid: Moisture, heat, sunlight, incompatible substances
Incompatible Materials: Water, oxidizers, strong bases, alcohols

Toxicological Information

Acute Toxicity: Harmful if inhaled, toxic by skin absorption and ingestion (quantitative LD50 not well established)
Skin Corrosion/Irritation: Causes burns, redness, blistering
Serious Eye Damage/Irritation: Causes severe damage, risk of blindness
Respiratory Sensitization: Irritating to mucous membranes and respiratory tract
Repeated Exposure: Risk of tissue destruction, possible target organ toxicity
Carcinogenicity: No classification; insufficient animal data
Mutagenicity: No established hazard, no reliable long-term studies
Reproductive Toxicity: Not determined, avoid exposure especially during pregnancy

Ecological Information

Ecotoxicity: Harmful to aquatic organisms, possible long-term effects, rapid hydrolysis in environment
Mobility: Not mobile in soil, binds to organic matter, hydrolyzes
Persistence: Not persistent, decomposes in water
Bioaccumulation: Not expected due to rapid breakdown
Degradation: Breaks down in water to bromide ions and related acid byproducts
Other Adverse Effects: Contributes to aquatic acidity, makes water toxic to fish and invertebrates

Disposal Considerations

Waste Disposal: Dispose via licensed chemical waste contractor, follow local, regional, national regulations
Incineration: Suitable only if incinerator is equipped for halogenated waste
Container Disposal: Triple rinse, puncture, dispose in authorized landfill
Disposal Precautions: Do not dispose down the drain, avoid environmental release, inform authorities if substantial release occurs

Transport Information

UN Number: 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (3-Bromopropionyl Bromide)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Label(s): Corrosive
Environmental Hazards: Dangerous for the environment, marine pollutant designation may apply
Special Precautions: Ship in original, sealed packaging, trained staff only
Transport Regulations: Comply with IATA, IMDG, ADR transportation guidelines

Regulatory Information

Inventory Status: Listed on TSCA, EINECS, other national inventories
OSHA Status: Regulated as corrosive, toxic substance
SARA Title III: Not specifically listed, but emergency planning and reporting may be required under general hazardous chemicals
RCRA Status: Classified hazardous waste under D Code for corrosive materials
Other Regulation: Comply with REACH, Canadian WHMIS, Australian ADG code, Japanese PRTR law
Label Requirement: Corrosive, toxic, harmful to environment; proper hazard phrases and precautionary measures must appear
Risk Phrases: R34, R37 (Causes burns, irritant to respiratory system)
Safety Phrases: S26, S36/37/39, S45 (In case of contact with eyes, rinse immediately; wear suitable protective clothing; in event of accident seek medical advice)