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Product Name: 3-Bromopropionitrile
Synonyms: β-Bromopropionitrile, 3-Bromopropanenitrile
CAS Number: 109-76-2
EC Number: 203-702-9
Recommended Use: Laboratory reagents and chemical manufacturing
Manufacturer/Supplier: Contact laboratory chemical supplier
Emergency Phone: Refer to local poisoning center or facility-specific emergency number
GHS Classification: Acute Toxicity (Oral, Inhalation, Dermal) Category 3; Skin Irritation Category 2; Eye Irritation Category 2; Acute Aquatic Toxicity Category 1
Signal Word: Danger
Hazard Statements: Toxic if swallowed, inhaled, or in contact with skin; Causes skin and eye irritation; Very toxic to aquatic life
Pictograms: Skull and crossbones, Exclamation mark, Dead fish/tree
Precautionary Statements: Avoid breathing dust, vapors, or spray; Wear protective gloves, clothing, and eye protection; Do not release to the environment
Physical Effects: Potential respiratory, dermal, and gastrointestinal tract irritation; Eye and skin irritation
Chemical Name: 3-Bromopropionitrile
Synonyms: Propiononitrile, 3-bromo-
Concentration: ≥99%
Molecular Formula: C3H4BrN
Molecular Weight: 133.97 g/mol
Impurities: Trace halogenated byproducts (if present, consult analysis sheet)
Inhalation: Move to fresh air right away; keep airway clear; provide oxygen if breathing is difficult; contact medical personnel immediately
Skin Contact: Remove contaminated clothing; rinse skin with plenty of water for at least 15 minutes; seek medical advice
Eye Contact: Rinse cautiously with water for several minutes, making sure to remove contact lenses if present; seek medical help immediately
Ingestion: Do not induce vomiting; rinse mouth with water if conscious; never give anything by mouth to an unconscious person; call toxicology center or physician
Most Important Symptoms: Burning sensation, coughing, headache, nausea, skin redness, eye pain
Notes for Physician: Treat symptomatically and supportively; monitor respiratory and cardiovascular function; consider delayed pulmonary effects
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Unsuitable Media: Avoid straight water streams
Specific Hazards: Produces toxic gases under fire conditions, such as hydrogen bromide and nitrogen oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, full protective gear
Firefighting Remarks: Stay upwind; cool tanks with water spray; avoid inhaling combustion byproducts
Hazardous Combustion Products: Hydrogen bromide, carbon oxides, nitrogen oxides
Personal Precautions: Wear chemical-resistant gloves, protective clothing, and goggles; avoid inhalation or direct contact
Environmental Precautions: Prevent further leakage or spillage; do not let product enter drains, waterways, or soil
Cleanup Methods: Absorb with inert materials (e.g., vermiculite, sand); place in a chemical waste container; ventilate affected area well
Decontamination: Wash site of spill with soap and water after removal of material
Disposal: Dispose of according to local, national, and international regulations
Handling: Use in well-ventilated fume hood; avoid breathing vapors and contact with skin or eyes; keep away from puddles or open flames; wear personal protection
Storage Conditions: Store in tightly closed containers; keep in a cool, dry, well-ventilated area away from sunlight and incompatible substances
Incompatibles: Strong oxidizers, strong acids, strong bases
Storage Temperature: Recommend storage at 2-8°C
Special Requirements: Separate from food and feedstuffs; avoid storing near chlorinated solvents or metals
Occupational Exposure Limits: No established limits for 3-Bromopropionitrile; handle as hazardous
Engineering Controls: Use chemical fume hood, emergency shower, eyewash station
Personal Protective Equipment: Chemical splash goggles, face shield, nitrile gloves, lab coat, chemical-resistant apron
Respiratory Protection: Use NIOSH-approved respirator if workplace exposure limits are exceeded or irritation is experienced
Hygiene Measures: Wash hands thoroughly after handling; do not eat or drink in work area
Exposure Monitoring: Regular air monitoring can help ensure safe workplace concentrations
Appearance: Colorless to light yellow liquid
Odor: Sharp, acrid
Odor Threshold: Not determined
pH: Not applicable
Melting Point/Freezing Point: -44°C
Boiling Point: 163°C
Flash Point: 67°C (closed cup)
Flammability: Combustible
Explosive Limits: Not available
Vapor Pressure: 2 mmHg (20°C)
Vapor Density: 4.6 (Air = 1)
Specific Gravity/Density: 1.53 (water=1)
Solubility: Slightly soluble in water, miscible with organic solvents
Partition Coefficient (Log Kow): 0.5 - 1.5 (estimated)
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Not available
Chemical Stability: Stable under recommended storage conditions
Reactive With: Strong oxidizing agents, strong acids, bases
Polymerization: Not expected to occur
Decomposition Products: Hydrogen bromide, carbon oxides, nitrogen oxides
Hazardous Reactions: Reacts with strong oxidants producing toxic gases
Conditions to Avoid: Extreme heat, open flames, incompatible materials
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Effects: Toxic if swallowed, inhaled, or by skin contact; burning sensation, coughing, nausea, headache
Skin Corrosion/Irritation: Can cause redness and pain
Eye Damage/Irritation: Redness, pain, possible severe irritation
Respiratory Effects: Breathing difficulties, choking sensation, upper respiratory tract irritation
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Reproductive Toxicity: No data available
LD50 (oral, rat): ~60 mg/kg
LD50 (dermal, rabbit): Data not available
Chronic Effects: Prolonged exposure may affect central nervous system, liver, kidneys
Other Data: No known mutagenic or teratogenic effects in humans
Toxicity: Very toxic to aquatic organisms; may cause long-term adverse effects in aquatic environment
Persistence and Degradability: Not readily biodegradable
Bioaccumulative Potential: Low (estimated, log Kow below 3)
Mobility in Soil: Likely to be mobile, poses risk of groundwater contamination
Other Adverse Effects: Harmful to most aquatic life, including fish, invertebrates
Avoid Release: Prevent spillage from entering waterways
Waste Treatment Methods: Incinerate with flue gas scrubber or dispose via licensed hazardous waste facility
Contaminated Packaging: Triple rinse containers before recycling or disposal; consult local disposal requirements
Precautions: Avoid disposal in household garbage, sewage, or surface water
Regulatory Information: Observe local and national environmental regulations for proper chemical waste disposal
UN Number: 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (Contains 3-Bromopropionitrile)
Transport Hazard Class: 6.1 (Toxic)
Packing Group: II
Environmental Hazards: Marine pollutant
Transport Labels: Toxic
Special Precautions: Keep away from incompatible materials and foodstuffs during transport; avoid rough handling or breakage
OSHA Status: Subject to the Hazard Communication Standard
TSCA: Listed in the Toxic Substances Control Act inventory
SARA 313: Not listed
REACH: Subject to registration; manufacturer or importer must ensure compliance
EINECS/ELINCS: Listed
WHMIS Classification: D1B (Toxic material), D2B (Other toxic effects)
Other Regulations: Subject to restrictions under local and national chemical safety and environmental protection acts
Labeling Requirements: Clearly labeled with GHS pictograms, signal and hazard statements, and manufacturer contact information for compliance
