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Product Name: 3,3'-Dichlorobenzidine Hydrochloride
Chemical Formula: C12H10Cl2N2•2HCl
Synonyms: o,o'-Dichlorobenzidine dihydrochloride
CAS Number: 612-83-9
Manufacturer: Please refer to supplier information
Intended Use: Intermediate for dyes and pigments, laboratory chemical
Emergency Contact: See local emergency numbers specific to your facility or region
Classification: Carcinogen (Category 1B), Acute Toxicity (Oral, Category 3), Skin sensitizer (Category 1), Eye irritant (Category 2A)
Signal Word: Danger
Hazard Statements: May cause cancer, toxic if swallowed, may cause allergic skin reaction, causes serious eye irritation
Pictograms: Health hazard, Exclamation mark, Skull and crossbones
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Target Organs: Liver, bladder, skin, eyes
Precautionary Statements: Avoid dust, wash hands after handling, wear protective gloves, avoid breathing vapors/dust, do not eat or drink near material
Chemical Name: 3,3'-Dichlorobenzidine Hydrochloride
Concentration: Greater than 97%
Impurities: Minor amounts of related aromatic amines and hydrochloride salt impurities
Other Components: No significant non-hazardous components
Inhalation: Move victim to fresh air, provide artificial respiration if not breathing, administer oxygen if breathing is difficult, seek medical attention
Skin Contact: Wash skin thoroughly with soap and water for at least 15 minutes, remove contaminated clothing, seek medical advice if irritation persists
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek immediate medical attention
Ingestion: Rinse mouth thoroughly with water, never induce vomiting, seek medical help immediately, do not give anything by mouth to an unconscious person
Note for Emergency Responders: Ensure use of personal protective equipment including gloves, goggles, and mask, avoid direct contact with chemical
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray (small fires), use water spray to cool containers exposed to fire
Specific Hazards: May release toxic and corrosive gases (hydrogen chloride, nitrogen oxides, chlorinated aromatic compounds) on decomposition
Protective Equipment: Self-contained breathing apparatus (SCBA) with full protective clothing
Advice for Firefighters: Approach fire from upwind, keep unnecessary personnel away, prevent runoff from fire control from entering waterways
Personal Precautions: Wear respiratory protection, chemical goggles, gloves, and full protective clothing, avoid inhalation or skin contact
Environmental Precautions: Do not allow to enter drains, surface water, or soil, contain spill if safe
Cleanup Methods: Sweep up material carefully using tools that do not create dust, place in appropriate labeled waste container, ventilate area, wash spill site thoroughly after cleanup
Decontamination: Use detergent and water, prevent dust formation
Safe Handling Advice: Use only in well-ventilated areas, minimize dust creation, avoid contact with skin or eyes, wash hands before breaks and at the end of the workday, prevent ingestion or inhalation
Storage Requirements: Store in original container, keep container tightly closed in a dry, cool, well-ventilated area away from incompatible substances (strong oxidizers, acids, bases), store away from direct sunlight and sources of ignition, keep out of reach of children and unauthorized personnel
Incompatible Materials: Strong oxidizing agents, acids, bases, strong reducing agents
Engineering Controls: Use chemical fume hood, mechanical ventilation, keep area dust-free
Exposure Limits: OSHA PEL: 0.1 mg/m3 (as benzidine, carcinogen), ACGIH TLV: 0.1 mg/m3 (skin, carcinogen)
Personal Protective Equipment: NIOSH-approved respirator, chemical safety goggles, impermeable gloves (nitrile, neoprene), lab coat or chemical-resistant coveralls
Hygiene Measures: No eating, drinking, or smoking in work area, wash hands thoroughly after handling, remove contaminated clothing and wash before reuse
Appearance: Light yellow to beige crystalline solid or powder
Odor: Little or none
Melting Point: 257-258°C (decomposes)
Boiling Point: Not available (decomposes before boiling)
Solubility: Soluble in water, sparingly soluble in ethanol
pH: Slightly acidic in aqueous solution
Vapor Pressure: Negligible at room temperature
Relative Density: 1.6 – 1.8 g/cm3
Flash Point: Not flammable under typical conditions
Partition Coefficient: Not determined
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not combustible, forms hazardous decomposition products when heated or exposed to strong acids, bases, or oxidizers
Hazardous Reactions: May produce toxic and corrosive fumes (HCl, nitrogen oxides, chlorinated organics)
Incompatible Materials: Strong oxidizing agents, strong acids, bases
Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, chlorinated aromatic compounds
Conditions to Avoid: Heat, sunlight, moisture, incompatible materials
Acute Toxicity: LD50 (oral, rat): 195 mg/kg
Chronic Health Effects: Proven carcinogenicity in animal studies, associated with bladder and liver tumors, may cause genetic mutations
Routes of Exposure: Ingestion, inhalation, dermal, ocular
Symptoms of Exposure: Skin irritation, eye irritation, respiratory tract symptoms, sensitization
Target Organs: Liver, kidney, bladder, blood
Sensitization: May cause allergic skin response
Mutagenicity: Reported genotoxic effects in experimental animals
Carcinogenicity Classification: IARC Group 2A (Probably carcinogenic to humans), NTP Known Carcinogen, OSHA Regulated Carcinogen
Environmental Fate: May persist in soil and sediments, potential for bioaccumulation
Aquatic Toxicity: Toxic to fish and invertebrates, LC50 (fish, 96h): data not fully available, but evidence points toward high toxicity
Mobility: Low volatility, movement through soil is likely to be limited, adheres to organic matter
Persistence and Degradability: Slow breakdown in environment, subject to microbial degradation but substantial persistence in water/soil
Ecotoxic Effects: Harmful to aquatic life with long-lasting effects, may disrupt aquatic ecosystems
Other Hazards: Avoid release to the environment, inform appropriate authorities in case of large spills
Waste Disposal Methods: Collect and place in approved, labeled containers for hazardous waste, follow federal, state, and local regulations for disposal, do not discharge to sewer or environment
Container Disposal: Triple rinse and puncture empty containers before disposal, treat as hazardous waste
Special Instructions: Incineration in an approved chemical incinerator with afterburner and scrubber preferred, chemical degradation requires expert supervision
UN Number: UN 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains 3,3'-Dichlorobenzidine Hydrochloride)
Transport Hazard Class: 6.1 (Toxic Substances)
Packing Group: II
Marine Pollutant: Yes
Special Precautions: Avoid release during transport, comply with all local, national, and international regulations, keep container tightly closed and upright
Labeling Requirements: Toxic symbol, environmentally hazardous
OSHA: Regulated carcinogen under OSHA standard 29 CFR 1910.1003
EPA: Listed as hazardous waste (U072), subject to reporting under SARA Title III Section 313
TSCA: Listed in the Toxic Substances Control Act Inventory
CERCLA: Reportable Quantity (RQ): 10 pounds
State Regulations: California Proposition 65: Listed carcinogen
Other International Regulations: Subject to regulation under REACH (EU), WHMIS (Canada—carcinogen, highly toxic), transport regulations in accordance with ADR, IMDG, and IATA
