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Product Name: (2S)-Cis-Hydroxylactam
Chemical Formula: C4H7NO2
Synonyms: 2-Hydroxy-4,5-dihydro-1H-pyrrol-2(3H)-one, Hydroxy-pyrrolidinone
CAS Number: 123456-78-9
Recommended Use: Research, pharmaceutical intermediate, chemical synthesis
Supplier: Refer to distributor’s contact information
Emergency Contact: Local health and safety office or poison control center
Classification: Eye irritation (Category 2A), Skin sensitization (Category 1), Specific target organ toxicity (Category 3, respiratory system)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation; May cause respiratory irritation; Can lead to skin sensitization with prolonged contact
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust/fume/gas/mist/vapors/spray; Wash hands thoroughly after handling; Wear protective gloves and eye/face protection
Potential Health Effects: Irritation to eyes, skin, respiratory tract; Possible allergic reaction on skin
Chemical Name: (2S)-Cis-Hydroxylactam
Chemical Formula: C4H7NO2
Concentration: >98% (pure substance)
Impurities: Trace organic material from synthesis (<0.5%)
Other Components: No additional stabilizers or preservatives used
Ingestion: Rinse mouth with water, never induce vomiting, seek immediate medical attention
Inhalation: Move affected individual to fresh air, loosen tight clothing, seek medical advice if symptoms persist
Skin Contact: Wash affected area with plenty of soap and water, remove contaminated clothing and footwear, consult a healthcare provider if irritation develops
Eye Contact: Rinse eyes carefully with water for several minutes, remove contact lenses if present, keep eyelids apart and flush with continuous water flow, seek medical attention promptly if irritation continues
Important Symptoms: Redness, itching, swelling of exposed tissues, coughing or shortness of breath possible after inhalation
Notes for Doctor: Symptomatic treatment, monitor for allergic reactions or respiratory complications
Suitable Extinguishing Media: Water mist, dry chemical, carbon dioxide, or foam
Unsuitable Media: Strong water jets as splashing may spread material
Specific Hazards: Thermal decomposition may produce nitrogen oxides, carbon oxides, irritating vapors or fumes
Firefighter Protection: Use self-contained breathing apparatus and full protective gear
Firefighting Advice: Cool exposed containers with water spray, stay upwind of fire
Personal Precautions: Use personal protective equipment, avoid breathing vapor or dust, ventilate area
Environmental Precautions: Prevent entry into waterways, drains, or soil
Containment: Collect spillage with inert absorbent material such as sand or diatomaceous earth, avoid raising dust
Clean-Up Methods: Transfer to a suitable container for proper disposal, wash spill area thoroughly, ventilate location
Notification: Report large spills to local authorities as required
Handling: Keep away from open flames, hot surfaces and sources of ignition, avoid formation of dust or aerosols
Safe Practices: Wear suitable personal protective equipment, work in a chemical fume hood
Hygiene: Do not eat, drink, or smoke while handling, always wash hands after use
Storage Conditions: Store in tightly closed containers, in a dry, cool, and well-ventilated area, keep container upright and sealed
Incompatible Materials: Strong oxidizers, strong acids, alkali materials
Storage Life: Stable under recommended storage conditions, avoid exposure to direct sunlight, humidity
Occupational Exposure Limits: No OSHA PEL or ACGIH TLV established for this substance
Engineering Controls: Work in a properly functioning chemical fume hood, ensure local exhaust ventilation
Personal Protective Equipment: Wear chemical-resistant gloves (like nitrile), splash-proof safety goggles, lab coat or apron
Respiratory Protection: Use approved mask or respirator if dust or vapor concentrations exceed safe levels
Environmental Protection: Use closed systems or local exhaust, avoid release into environment
Appearance: White to pale beige crystalline powder
Odor: Mild, almost odorless
Odor Threshold: Not established
pH (1% Solution): Approximately 7.0-8.0
Melting Point: 156–160°C
Boiling Point: Decomposes before boiling
Flash Point: Not easily flammable, >200°C
Solubility in Water: Moderately soluble
Solubility in Other Solvents: Slightly soluble in ethanol, insoluble in non-polar solvents
Vapor Density: Not applicable (non-volatile)
Partition Coefficient: log Kow ≈ -0.3 (estimated)
Evaporation Rate: Not applicable
Auto-ignition Temperature: >260°C
Decomposition Temperature: >170°C
Molecular Weight: 101.10 g/mol
Viscosity: Not applicable (solid substance)
Chemical Stability: Stable under normal use and storage, sensitive to strong acids and bases
Conditions to Avoid: Excess heat, moisture, strong sunlight, sources of ignition
Materials to Avoid: Reactive with oxidizing agents, strong reducing agents, acid chlorides
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, other unidentified organic fragments
Reactivity: May react with strong oxidants, not self-reactive
Polymerization: No hazardous polymerization expected
Acute Toxicity: No precise data, studies suggest low oral and dermal toxicity in animal models
Irritation/Corrosion: Eye and skin irritant potential; significant exposure may cause redness, itching, swelling
Sensitization: Repeated or prolonged contact can occasionally lead to allergic-type skin responses
LC50/LD50: Not determined in humans, acute oral LD50 in rodents estimated at >2000 mg/kg
Chronic Effects: No long-term studies available; persistent exposure likely to irritate mucous membranes
Carcinogenicity: Not listed by IARC, NTP, OSHA
Mutagenicity: No in vitro or in vivo mutagenicity reported
Reproductive Toxicity: Data lacking, careful handling recommended
Route of Exposure: Eyes, skin, ingestion, inhalation possible
Ecotoxicity: No reliable studies available, limited data suggest low to moderate toxicity for aquatic life
Persistence and Degradability: Expected to be slowly biodegradable under aerobic conditions, breakdown products not fully identified
Bioaccumulation Potential: Low, based on predicted log Kow value
Mobility in Soil: Likely moderate to high mobility based on water solubility and partition coefficients
Aquatic Toxicity: No data for fish, daphnia, or algae; prudent practice avoids introducing into groundwater, rivers, lakes
Waste Treatment Methods: Handle as hazardous chemical waste due to potential sensitization and unknown environmental impact
Container Handling: Triple rinse containers, then dispose in accordance with local chemical waste procedures
Recycling or Reuse: Not recommended unless purity can be verified by qualified personnel
Local Regulations: Consult local and national environmental authorities for approved waste handling methods
Avoid: Discharge to sewage systems, storm drains, or open land
UN Number: Not classified for transport under most national and international regulations
Transport Hazard Class: Not regulated as dangerous
Packing Group: Not assigned
Proper Shipping Name: (2S)-Cis-Hydroxylactam
Special Precautions: Secure tightly closed container, store away from incompatible materials, protect from physical damage
Transportation Labels: None required
U.S. Regulations (TSCA): Not listed on TSCA inventory, for research use only
Europe (REACH): Not registered, recommended only for R&D under the direction of technically qualified persons
SARA Title III: Not subject to reporting requirements
California Prop 65: Not listed
Canadian DSL/NDSL: Not listed
Hazard Communication: Handled as a laboratory chemical, safety training required
Other Information: Chemical must be used in accordance with applicable chemical hygiene and safety practices
