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Product Name: 21-Hydroxy-20-Methylpregn-4-En-3-One
Synonyms: 21-Hydroxy-20-methylpregn-4-en-3-one; Steroid intermediate
Recommended Use: Laboratory chemical, pharmaceutical research, chemical synthesis intermediary
Manufacturer: [Manufacturing Organization]
Contact Information: [Address, emergency phone, business phone]
GHS Classification: Skin Irritant (Category 2), Eye Irritant (Category 2A), Specific organ toxicity (repeated exposure, Category 2)
Pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: Causes skin irritation; May cause damage to organs through prolonged or repeated exposure; Causes serious eye irritation
Precautionary Statements: Avoid breathing dust; Wear protective gloves, eye protection; Wash hands after handling; Seek medical advice if symptoms persist
Physical Hazards: No robust fire or explosion risk under normal handling
Chemical Identity: 21-Hydroxy-20-Methylpregn-4-En-3-One
CAS Number: [CAS Number]
EC Number: [EC Number]
Purity: ≥98%
Impurities: Trace related steroids, solvents below reporting threshold
Molecular Formula: C22H32O3
Inhalation: Move person to fresh air. Seek medical attention if symptoms develop—coughing, shortness of breath.
Skin Contact: Rinse skin with plenty of water; remove contaminated clothing. Call for medical help if irritation continues.
Eye Contact: Flush immediately with clean water for at least 15 minutes, and keep eyelids open. Consult a physician.
Ingestion: Do not induce vomiting; rinse mouth with water if the affected individual is conscious. Seek immediate medical care.
Suitable Extinguishing Media: Carbon dioxide, dry chemical, water spray, foam.
Unsuitable Media: Direct water jets, as this could disperse material.
Hazardous Combustion Products: Carbon oxides, potentially irritating or toxic fumes
Protective Equipment for Firefighters: Full protective gear and positive pressure self-contained breathing apparatus
Advice for Firefighters: Avoid breathing combustion gases; cool containers exposed to fire with water spray.
Personal Precautions: Use appropriate PPE—protective gloves, safety goggles, dust mask or respirator.
Environmental Precautions: Prevent further leakage or spillage if safe; avoid runoff into soil, drains, and waterways.
Methods for Cleanup: Sweep up (avoid generating dust); collect in closed containers for proper disposal; ventilate area; wash spill area with detergents.
Handling: Avoid skin and eye contact; wear suitable PPE; use with adequate ventilation or local exhaust.
Storage Conditions: Store in tightly closed containers away from incompatible materials; cool, dry, well-ventilated area recommended.
Incompatibilities: Strong oxidizing agents, acids/herbicides
Specific End Uses: Intended for research and professional use only
Exposure Limits: No workplace exposure limits established
Engineering Controls: Fume hood or general exhaust ventilation recommended
Personal Protection: Chemical-resistant gloves (nitrile recommended), safety glasses with side shields, lab coat, appropriate respirator for dust if concentration exceeds exposure guideline.
Hygiene Measures: Wash hands after handling, remove contaminated clothing, clean before reuse
Appearance: White to off-white crystalline powder
Odor: No characteristic odor
Odor Threshold: Not determined
pH: Not applicable
Melting Point: 205-215°C
Boiling Point: Not determined (decomposes before boiling)
Flash Point: Not applicable
Flammability: Non-flammable as supplied
Explosive Limits: Not determined
Vapor Pressure: Negligible
Solubility: Poorly soluble in water; soluble in DMSO, ethanol
Partition Coefficient (n-octanol/water): Not measured
Decomposition Temperature: Above 250°C
Viscosity: Not applicable
Stability: Stable under standard temperatures and recommended use conditions
Reactivity: No dangerous reactions expected under normal conditions
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, irritant fumes
Conditions to Avoid: High heat, strong acids, oxidizing agents, prolonged UV exposure
Polymerization: Will not occur
Routes of Exposure: Inhalation, ingestion, skin or eye contact
Acute Toxicity: LD50 not established in animal models; dust may irritate upper respiratory tract
Skin Corrosion/Irritation: Prolonged exposure may cause skin irritation, redness
Serious Eye Damage/Irritation: May result in pain, redness, tearing
Carcinogenicity: No experimental data indicating carcinogenicity in lab animals
Reproductive Toxicity: No conclusive data; handle as possible reproductive hazard
Other Data: Chronic exposure may pose risks to hormone cycles or organ systems; effects not fully characterized
Toxicity: Not expected to be acutely toxic to aquatic organisms, but lack of complete assessment limits certainty
Persistence and Degradability: Likely to be persistent based on structure; slow environmental degradation
Bioaccumulative Potential: Moderate potential due to lipophilic structure; further studies recommended
Mobility in Soil: Limited mobility due to low water solubility
Other Adverse Effects: Avoid discharge into environment; effects on microflora unknown
Waste Treatment Methods: Disposal through licensed chemical waste contractor; follow local, regional, and national regulations
Contaminated Packaging: Empty containers should be handled as hazardous; dispose as per product
Special Precautions: Prevent environmental release during disposal
UN Number: Not regulated under ADR/RID, IMDG, IATA
Proper Shipping Name: Not regulated
Transport Hazard Class: Not classified
Packing Group: Not assigned
Special Precautions: Protect from physical damage during transport; avoid exposure to direct sunlight and moisture
TSCA: Substance not listed in the United States Toxic Substances Control Act inventory
REACH Status: Not registered for ECHA evaluation
SARA/OSHA: Material not regulated under major U.S. hazard lists
WHMIS Classification: Not classified as a controlled product in Canada
Other Regulations: Users must comply with local, national, and international regulations regarding laboratory chemicals; safety training and documentation required
