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Product Name: 2-Nitrobromobenzene
Chemical Formula: C6H4BrNO2
CAS Number: 577-19-5
EC Number: 209-400-3
Synonyms: o-Bromonitrobenzene, 1-Bromo-2-nitrobenzene
Recommended Use: Intermediate in organic synthesis, chemical research
Supplier Identification: Chemical manufacturer or distributor details provided on product label
Emergency Contact: Local poison control or fire department, manufacturer’s emergency telephone number
GHS Classification: Acute toxicity (oral, dermal, inhalation), Skin irritation, Eye irritation, Specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed, harmful in contact with skin, harmful if inhaled, causes skin irritation, causes serious eye irritation, may cause damage to organs through prolonged or repeated exposure
Precautionary Statements: Avoid breathing dust or vapors, wash thoroughly after handling, use in well-ventilated areas, wear protective gloves, clothing, eye and face protection
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Chemical Name: 2-Nitrobromobenzene
Identified Impurities: Product usually contains less than 1% unidentified organics; trace organohalide impurities could be present
Concentration: More than 98% by weight
Chemical Class: Aromatic nitro compounds
Additional Information: No major stabilizers or preservatives
Inhalation: Move exposed person to fresh air; seek medical attention if symptoms develop, such as coughing or difficulty breathing
Skin Contact: Remove contaminated clothing, rinse skin with soap and plenty of water, medical attention for irritation or allergic reactions
Eye Contact: Rinse thoroughly with clean water for at least fifteen minutes; remove contact lenses if present and seek immediate medical attention
Ingestion: Rinse mouth, do not induce vomiting, get medical aid promptly, monitor for signs of nausea or abdominal pain
Notes for Medical Personnel: Treat symptomatically, monitor for methemoglobinemia, provide supportive care
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray for larger fires
Specific Hazards Arising From Chemical: Burns may release toxic gases such as nitrogen oxides, hydrogen bromide, and carbon oxides
Protective Equipment: Wear self-contained breathing apparatus, chemical-resistant suit, avoid inhalation of combustion products
Advice for Firefighters: Cool exposed containers with water, keep away from runoff, avoid direct contact with releases
Personal Precautions: Evacuate non-essential personnel, wear appropriate personal protection (respirator, gloves, eyewear, protective clothing)
Environmental Precautions: Prevent further leakage or spillage if safe to do so, do not release into waterways, soil, or drains
Clean-Up Methods: Absorb spills with inert material (sand, vermiculite), collect into chemical waste container, ventilate area, clean contaminated area with water and detergent
Safe Handling Procedures: Use only in fume hood or well-ventilated space; minimize dust generation; avoid inhalation, ingestion, or skin contact
Safe Storage Conditions: Store in tightly sealed original containers, away from direct sunlight, moisture, oxidizers, acids, and heat sources
Incompatible Materials: Strong oxidizers, acids, reducing agents
Special Requirements: Only trained personnel should handle bulk quantities; keep away from ignition sources
Recommended Engineering Controls: Local exhaust ventilation, general room ventilation, safety shower and eyewash station in the work area
Exposure Limits: No established OSHA, ACGIH or NIOSH limits for 2-nitrobromobenzene; good industrial hygiene practices advised
Personal Protective Equipment (PPE): Chemical splash goggles, gloves made from nitrile or neoprene, laboratory coat or chemical protective suit; NIOSH-approved respirator for dusty or poorly ventilated areas
Hygiene Measures: Wash hands after handling, remove contaminated clothing before leaving work area, do not eat, drink, or smoke while using product
Appearance: Pale yellow to yellow crystalline solid
Odor: Weak aromatic odor
Odor Threshold: Not available
pH: Not applicable (solid)
Melting Point/Freezing Point: 56–59°C
Boiling Point: 273°C (decomposes)
Flash Point: 133°C (closed cup)
Evaporation Rate: Not available
Flammability: Not highly flammable but combustible
Vapor Pressure: Low; less than 0.01 mmHg (25°C)
Solubility in Water: Low; slightly soluble
Partition Coefficient (log Pow): 2.8
Vapor Density: Heavier than air
Relative Density: 1.77 g/cm³
Autoignition Temperature: Not available
Decomposition Temperature: Above 250°C (releases toxic fumes)
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizers, acids, reducing agents
Conditions to Avoid: Excess heat, open flames, moisture, incompatible chemicals
Hazardous Decomposition Products: Nitrogen oxides, hydrogen bromide, carbon monoxide and dioxide
Polymerization: Not known to occur
Likely Routes of Exposure: Skin contact, eye contact, inhalation, ingestion
Acute Toxicity: Oral LD50 (rat) approximately 500 mg/kg; slight to moderate toxicity by skin or inhalation
Skin Irritation: Causes irritation; allergic reactions possible on prolonged exposure
Eye Damage/Irritation: Causes moderate to strong irritation
Inhalation Effects: May cause respiratory tract irritation, coughing, shortness of breath
Sensitization: No known respiratory sensitizing effects
Chronic Effects: Prolonged exposure may affect liver, kidneys, or cause methemoglobinemia
Carcinogenicity: No data indicating carcinogenic potential in current literature
Reproductive/Developmental Toxicity: No established effects on fertility or development
Ecotoxicity: May be harmful to aquatic organisms, possible long-term adverse effects in aquatic environments
Persistence and Degradability: Not readily biodegradable; may persist in environment
Bioaccumulation Potential: Moderate, due to log Pow above 2
Mobility in Soil: Low solubility suggests limited mobility; may bind to soil particles
Other Environmental Hazards: Do not release to environment without proper treatment
Disposal Methods: Incinerate in accordance with local, regional, and national regulations, preferably at licensed hazardous waste facility
Contaminated Packaging: Dispose of as hazardous waste, do not reuse containers
Waste Codes: Consult local regulatory requirements for proper classification and handling
Precautions: Do not allow product or contaminated material to enter surface water, groundwater, or sewage system; use appropriate containment
UN Number: 2810
Proper Shipping Name: Toxic liquids, organic, n.o.s. (contains 2-nitrobromobenzene)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Not classified as marine pollutant under IMDG; may still pose local aquatic risk
Special Precautions: Avoid release during transport, ensure drums or packaging are well-sealed and labelled
OSHA Status: Not listed as hazardous by OSHA, but handle as toxic chemical
TSCA Inventory: Listed
REACH Status: Registered or pre-registered (within EU)
Label Elements: GHS label required; hazard pictogram (exclamation mark, health hazard), signal word required
SARA Title III: Not listed as an extremely hazardous substance, not subject to Section 313 reporting
Other Regulations: Chemical subject to workplace control, environmental discharge controls, voluntary exposure assessments in several countries
Workplace Labelling Requirements: Container labels must show product identifier, hazard statements, supplier details, precautions, and appropriate pictograms
