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Product Name: 2-Nitrobiphenyl
Synonyms: o-Nitrobiphenyl, 2-Biphenylnitro
CAS Number: 86-51-1
Molecular Formula: C12H9NO2
Molecular Weight: 199.21 g/mol
Recommended Use: Research, synthesis, intermediate
Manufacturer: Details available from supplier
Emergency Contact: Chemtrec, 1-800-424-9300 (US)
Classification: Acute Toxicity (Oral, Dermal, Inhalation), Carcinogenicity (IARC Group 2B), Eye and Skin Irritant
Signal Word: Danger
Hazard Statements: Toxic if swallowed or inhaled; Harmful to skin and eyes; Suspected of causing cancer; May cause damage to organs through prolonged or repeated exposure
Pictograms: Health hazard, exclamation mark, skull and crossbones
Route of Exposure: Skin contact, inhalation, ingestion
Chemical Name: 2-Nitrobiphenyl
CAS Number: 86-51-1
Concentration: ≥98%
Impurities: Trace biphenyls, nitro compounds
Inhalation: Move to fresh air. Seek medical attention if symptoms continue. Oxygen may help breathing. Remove contaminated clothing.
Ingestion: Rinse mouth thoroughly, keep individual at rest, seek immediate medical help. Do not induce vomiting unless directed by medical personnel.
Skin Contact: Wash skin thoroughly with soap and water. Remove contaminated clothing and wash before reuse. Get medical attention for persistent irritation or symptoms.
Eye Contact: Rinse eyes cautiously for several minutes under running water. Remove contact lenses if present and easy to do. Get prompt medical advice.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide (CO2), foam
Unsuitable Media: Straight water jets (may spread fire)
Hazardous Combustion Products: Emits toxic and irritating gases such as nitrogen oxides, carbon oxides
Protective Equipment: Self-contained breathing apparatus, full protective gear
Firefighting Instructions: Cool containers with water spray. Prevent runoff from entering drains or watercourses.
Personal Precautions: Keep unnecessary personnel away. Avoid inhalation, skin, and eye contact. Use protective clothing and a NIOSH-approved respirator, gloves, chemical goggles.
Environmental Precautions: Avoid release into environment, prevent spill from entering waterways and soil. Evacuate spill area.
Clean-Up Methods: Soak up with inert absorbent material (sand, earth, vermiculite), collect in securely labeled containers for proper disposal. Ventilate area, wash spill zone thoroughly after material pickup.
Handling: Use in well-ventilated areas. Do not inhale dust, vapor, or spray. Avoid contact with skin, eyes, and clothing. Wear proper PPE at all times. Avoid eating, drinking, and smoking where material is handled.
Storage: Keep container tightly closed in a secure, cool, dry, and well-ventilated area. Store chemicals away from heat, sparks, hot surfaces, and incompatible materials including strong oxidizers and acids. Label containers properly and segregate from non-chemicals.
Occupational Exposure Limits: No OSHA PEL, ACGIH TLV, or NIOSH REL established for this substance, but minimize all exposure.
Engineering Controls: Use fume hoods or local exhaust ventilation to control dust/vapors in workspace.
Personal Protection: NIOSH-approved respirator, impervious gloves, face shield or chemical safety goggles, lab coat or coveralls, closed-toe shoes. Eye-wash and safety shower stations required.
Hygiene: Wash hands thoroughly after handling, remove protective equipment before entering eating or rest areas.
Appearance: Yellow crystalline solid
Odor: Mild aromatic
Odor Threshold: Not determined
pH: Not applicable
Melting Point: 70-74°C (158-165°F)
Boiling Point: 350°C (662°F) at 760 mmHg
Flash Point: 171°C (340°F)
Evaporation Rate: Not available
Flammability: Not highly flammable, avoid open flame
Vapor Pressure: Low, negligible at room temperature
Vapor Density: Not available
Solubility: Insoluble in water; soluble in ethanol, ether
Partition Coefficient (log Kow): Approx. 3.63
Decomposition Temperature: Not available
Viscosity: Not applicable
Chemical Stability: Stable under normal conditions of storage and use
Reactivity: Avoid strong oxidizing agents, reducing agents, acids
Polymerization: Not expected under normal conditions
Hazardous Decomposition: Decomposes to toxic fumes like NOx and COx on heating or burning
Conditions to Avoid: Excessive heat, incompatible substances, moisture
Routes of Exposure: Skin, eyes, inhalation, ingestion
Acute Toxicity: Toxic (LD50 oral, rat: 300 mg/kg); symptoms include headache, dizziness, nausea
Chronic Effects: Prolonged exposure may damage liver, kidneys, and other organs; skin absorption risk
Carcinogenicity: IARC 2B (possibly carcinogenic to humans)
Mutagenicity: Evidence of genetic toxicity in animal studies
Reproductive Effects: No conclusive data, avoid unnecessary exposure
Sensitization: May cause allergic skin or respiratory reaction in some individuals
Aquatic Toxicity: Toxic to aquatic organisms; acute LC50 (fish, 96hr): 5-50 mg/L
Persistence and Degradability: Not readily biodegradable; may persist in environment
Bioaccumulation Potential: Moderate based on estimated log Kow
Mobility: Low mobility in soil due to low water solubility
Other Adverse Effects: May cause long-term adverse effects in the aquatic environment
Waste Handling: Collect chemical waste in properly labeled, sealed containers. Do not dispose of in municipal waste or natural environments.
Disposal Methods: Incinerate at an approved chemical waste facility, following all local, state, and federal regulations.
Container Disposal: Triple rinse, puncture, and send empty containers to licensed waste handler.
Regulatory Requirements: Follow all waste management regulations, report large spills to authorities.
UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (2-Nitrobiphenyl)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Marine Pollutant: Yes
Special Precautions: Keep containers securely closed and upright. Avoid exposure to heat and vibration during transport. Emergency responders should have proper protective equipment.
U.S. Regulations: Listed on TSCA Inventory; subject to SARA 313 (toxic chemical); RCRA hazardous waste
International Status: Included in several country-specific inventories, regarded as hazardous under EU REACH and other regulations
Hazard Categories: Immediate (acute) health hazard, delayed (chronic) health hazard, environmental hazard
Labeling: Proper GHS and hazard communication labels required at all times during storage, handling, and transport.
