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Product Name: 2-Nitrobenzenesulfonyl Chloride
Synonyms: Orthonitrobenzenesulfonyl chloride, o-Nitrobenzenesulfonyl chloride, NSC 4084
CAS Number: 612-23-7
Molecular Formula: C6H4ClNO4S
Molecular Weight: 221.62 g/mol
Recommended Use: Chemical synthesis, pharmaceutical intermediates, laboratory reagent
Manufacturer and Contact: Refer to supplier’s literature for phone numbers and emergency contacts
Classification: Acute toxicity (oral, inhalation, dermal), Skin corrosion/irritation, Serious eye damage/eye irritation
Hazard Statements: Harmful if swallowed or inhaled. Causes skin burns and serious eye damage. May cause respiratory irritation.
Pictogram: Corrosive, Exclamation mark
Precautionary Statements: Avoid breathing dust or fumes. Wear protective gloves and eye protection. Use only in well-ventilated area. Wash thoroughly after handling.
Signal Word: Danger
Chemical Identity: 2-Nitrobenzenesulfonyl chloride
Chemical Formula: C6H4ClNO4S
CAS Number: 612-23-7
Concentration: 99% or greater (typical for laboratory purposes)
Impurities: Trace residuals may exist from synthesis; consult supplier for further specification
Inhalation: Remove person to fresh air. Monitor for respiratory distress. Seek immediate medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing. Rinse skin thoroughly with water for at least 15 minutes. Get medical help if irritation develops.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Immediately continue rinsing, and call a physician.
Ingestion: Rinse mouth. Do not induce vomiting. Seek medical care right away.
Most Important Symptoms and Effects: Severe irritation, burns, coughing, difficulty breathing, redness and pain
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Specific Hazards: Emits toxic fumes of nitrogen oxides, sulfur oxides, hydrogen chloride when heated or burned
Protective Equipment: Full protective suit, self-contained breathing apparatus required for firefighters
Special Precautions: Avoid runoff from fire control or dilution water, as it may cause pollution. Move containers out of fire area if safe.
Personal Precautions: Evacuate unnecessary personnel. Avoid inhalation and contact with skin and eyes. Wear appropriate PPE.
Environmental Precautions: Prevent spillage from entering drains, surface water, or soil.
Methods for Clean-up: Absorb spills with inert absorbent material (sand, earth, vermiculite). Place into labeled, sealable containers for waste disposal. Ventilate area and wash spill site after pickup.
Handling: Work in a properly ventilated fume hood. Avoid dust creation and contact with skin, eyes, or clothing. Use appropriate personal protective equipment.
Storage: Store in tightly closed containers. Keep away from moisture, incompatible materials (see Stability and Reactivity). Store in a cool, dry, ventilated area away from heat sources and direct sunlight.
Storage Conditions: Store locked up in corrosion-resistant containers.
Exposure Limits: No specific OEL established; minimize exposure due to toxicity concerns.
Engineering Controls: Use local exhaust ventilation or chemical fume hood to minimize airborne exposure.
Respiratory Protection: Use approved respirator if airborne concentrations exceed recommended limits.
Skin Protection: Impervious gloves (nitrile recommended), lab coat or apron.
Eye Protection: Safety glasses with side shields, splash goggles.
Other Protection: Suitable emergency eye wash and safety shower in work area.
Appearance: Pale yellow crystalline powder
Odor: Not significant or faint irritant
Odor Threshold: Not determined
pH: Not applicable (solid)
Melting Point/Freezing Point: 81-84°C
Boiling Point: Decomposes before boiling
Flash Point: Not available
Evaporation Rate: Not determined
Flammability: Not flammable in solid form
Explosive Properties: Not classified as explosive
Vapor Pressure: Not significant at room temperature
Relative Density: 1.64 g/cm³ (approximate)
Solubility: Slightly soluble in water. Soluble in organic solvents including ether and acetone.
Partition Coefficient (n-octanol/water): Not available
Decomposition Temperature: Above 150°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions. Sensitive to moisture and prolonged contact with air.
Reactivity: Reacts violently with water, amines, alcohols, strong bases, and strong oxidizers. Produces toxic gases on decomposition or hydrolysis.
Decomposition Products: Hydrogen chloride gas, nitrogen oxides, sulfur oxides, other hazardous compounds.
Conditions to Avoid: Exposure to moisture, heat, open flames, incompatible substances.
Polymerization: Not expected to occur.
Acute Toxicity: Harmful if swallowed or inhaled; may cause severe damage to tissue in the mouth, throat, or respiratory tract.
Skin Corrosion/Irritation: Causes severe burns, blistering, pain, and delayed healing.
Serious Eye Damage/Irritation: Can cause blindness, severe pain, and permanent damage.
Respiratory Sensitization: Can cause coughing, sore throat, asthma-like symptoms.
Chronic Effects: No evidence for carcinogenicity, mutagenicity, or reproductive toxicity has been reported, though long-term exposure may aggravate existing medical conditions.
Target Organs: Eyes, skin, respiratory system
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Ecotoxicity: Very toxic to aquatic life based on structural similarity and sulfonyl chloride reactivity.
Persistence and Degradability: Not rapidly biodegradable in the environment. Hydrolysis slowly forms toxic, persistent products.
Bioaccumulation: Potential to bioaccumulate is low; limited data available.
Mobility in Soil: Binds with organic matter, but potential for groundwater contamination if released.
Other Adverse Effects: Produces acidic and toxic byproducts on hydrolysis or incineration.
Waste Disposal Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber in accordance with local, regional, or national regulations.
Contaminated Packaging: Dispose of as hazardous waste. Triple rinse containers before disposal or recycling.
Special Precautions: Do not dispose into the environment or drainage systems.
Regulations: Consult local authorities for specific disposal requirements.
UN Number: 3261
UN Proper Shipping Name: Corrosive Solid, Acidic, Organic, N.O.S. (contains 2-Nitrobenzenesulfonyl chloride)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Labels: Corrosive
Marine Pollutant: Not classified as such under IMDG, but take precautions to avoid spills
Special Transport Precautions: Avoid releasing to environment, secure package to prevent leaks
Workplace Regulations: Covered by OSHA Hazard Communication Standard in the US; classified hazardous for workplace labeling
Environmental Regulations: Subject to reporting under CERCLA due to hazardous properties
Other National/International Regulations: Inventory listings on TSCA (US), EINECS (EU), AICS (Australia), DSL (Canada)
Restrictions: Not regulated under the Montreal Protocol, Rotterdam or Stockholm Conventions; use limited to industrial and laboratory settings
