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Chemical Name: 2-Nitroanisole
SYNONYMS: o-Nitroanisole
CAS Registry Number: 91-23-6
Molecular Formula: C7H7NO3
Molecular Weight: 153.14 g/mol
Appearance: Pale yellow liquid
Odor: Slightly sweet, aromatic smell
Suggested Uses: Dye intermediates, chemical synthesis, research laboratories
Manufacturer/Supplier Details: Available through standard chemical suppliers or manufacturers handling aromatic nitro compounds
Hazard Classification: Flammable liquid, Acute Toxicity (Oral, Inhalation), Skin and Eye Irritant, Suspected Carcinogen
GHS Label Elements: Signal word DANGER; pictograms for flame, health hazard, and exclamation mark
Hazard Statements: May cause damage to organs through prolonged or repeated exposure, Harmful if swallowed, Causes skin and eye irritation, May cause respiratory irritation, Suspected of causing cancer
Precautionary Statements: Wear personal protective equipment, avoid release to the environment, wash skin thoroughly after handling, use in well-ventilated areas, do not breathe vapors or mists
Target Organs: Liver, kidney, central nervous system, skin, respiratory system
Main Ingredient: 2-Nitroanisole
Chemical Purity: ≥ 98% by weight
Impurities: Trace related aromatic nitro compounds ≤ 2%
Additives: No stabilizing additives reported
Other Components: No other substances or mixtures considered hazardous present in concentrations above regulatory disclosure thresholds
Inhalation: Remove person to fresh air, monitor breathing, seek immediate medical attention if symptoms persist. Provide oxygen or artificial respiration if breathing becomes difficult.
Skin Contact: Remove contaminated clothing, wash affected skin area with plenty of water and soap for at least 15 minutes, seek medical treatment for persistent irritation, launder contaminated clothing before reuse.
Eye Contact: Rinse eyes immediately with water for at least 15 minutes, lifting eyelids to ensure thorough flushing, obtain prompt medical evaluation even if no symptoms appear.
Ingestion: Do not induce vomiting, rinse mouth with water, never give anything by mouth to an unconscious person, transport to medical facility as soon as possible.
Symptoms of Exposure: Irritation to mucous membranes, headache, nausea, dizziness, possible confusion or loss of coordination, skin redness or rash, eye discomfort, increased risk with prolonged or high-concentration exposure.
Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, water spray (not directly on burning liquid)
Unsuitable Extinguishing Media: Direct water jet may spread the fire
Specific Hazards: Vapors can form explosive mixtures with air, combustion releases toxic fumes including oxides of nitrogen, carbon monoxide, and carbon dioxide
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective gear, prevent runoff from entering drains or water sources
Fire-Fighting Instructions: Move containers from fire area if possible, cool adjacent containers with water spray, avoid inhaling vapors or smoke
Personal Precautions: Evacuate unnecessary personnel, ventilate area, use personal protective equipment including respiratory, eye and skin protection.
Environmental Precautions: Prevent spillage or runoff into soil, waterways, drains, or sewers, notify relevant authorities if contamination occurs
Containment Methods: Absorb spill with inert material like sand, earth, or vermiculite, collect in suitable containers for disposal
Cleaning Methods: Wash residual material from surfaces with water while containing runoff, ventilate area after cleanup
Disposal of Contaminated Material: Treat as hazardous waste, follow federal, state, and local regulations for safe disposal
Safe Handling Guidelines: Use in a well-ventilated space, avoid contact with eyes, skin, or clothing, avoid inhaling vapors, Handle with proper protective equipment
Preventive Measures: Keep containers tightly sealed when not in use, avoid static discharge, ground and bond all containers during transfer
Storage Recommendations: Store in cool, dry, well-ventilated area, away from heat sources or open flames, segregate from strong oxidizers, acids, and bases
Container Materials: Use chemical-resistant containers such as glass or high-density polyethylene, keep product away from incompatible substances
Incompatibilities: Strong oxidizing agents, strong acids, alkalis, reducing agents may provoke hazardous reaction
Exposure Limits: No occupational exposure limits established by OSHA, ACGIH; minimize exposure as much as possible
Engineering Controls: Chemical fume hood recommended for laboratory work, use of process enclosures or local exhaust if large volumes handled
Personal Protection: Nitrile or neoprene gloves, safety goggles, face shield for splash risk, lab coat or protective coveralls, use approved respirator for vapor or mist levels above exposure limits
Hygiene Measures: Wash hands before breaks, after handling, and after work, do not eat, drink, or smoke while working with this chemical
Appearance: Pale yellow oily liquid
Odor: Faint aromatic
pH: Not applicable (neutral organic compound)
Boiling Point: 257-259°C
Melting Point: -2°C
Flash Point: 120°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable
Vapor Pressure: 0.03 mmHg at 25°C
Vapor Density: 5.3 (air = 1)
Relative Density: 1.232 g/cm³ at 25°C
Solubility in Water: Approximately 0.3 g/L at 25°C (slightly soluble)
Partition Coefficient (log Kow): 1.8
Auto-ignition Temperature: 405°C
Decomposition Temperature: Not available
Viscosity: Low to moderate viscosity, value not specified
Chemical Stability: Stable under ordinary conditions of handling and storage
Reactivity: Not reactive under normal conditions, forms hazardous gases with incompatible chemicals
Condition to Avoid: High temperature, open flames, sources of ignition, incompatible contact with oxidizers or strong acids
Hazardous Decomposition Products: Oxides of nitrogen, carbon monoxide, carbon dioxide
Polymerization: Does not polymerize
Incompatibility: Strong oxidizing agents, strong acids, alkalis, reducing agents, avoid mixing with agents increasing explosive or heat release potential
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Effects: Causes skin and eye irritation, headache, dizziness, gastrointestinal discomfort, possible liver and kidney effects
Chronic Effects: Prolonged exposure may impact liver and kidney function, risk of methemoglobinemia, possible carcinogenicity (IARC classification 2B, possibly carcinogenic to humans)
Carcinogenicity: Animal studies indicate increased risk for tumors in multiple organs after chronic exposure, limited human data, concern for occupational exposure
Mutagenicity: Mutagenic effects reported in laboratory testing
Reproductive Toxicity: No reliable data available
LD50 (oral, rat): Between 740 and 1000 mg/kg
Symptoms of Overexposure: Cyanosis, weakness, anemia, headache, breathing difficulties, nausea, vomiting, possible depression of central nervous system
Ecotoxicity: Toxic to aquatic organisms, risk for long-term adverse effects in aquatic environment
Persistence and Degradability: Not readily biodegradable, may persist in soil and sediments
Bioaccumulative Potential: Moderate potential based on log Kow values, risk of build-up in aquatic food chains
Mobility in Soil: Moderately adsorbed to soil particles, possible migration to groundwater under certain conditions
Other Adverse Effects: Breakdown products may be harmful to wildlife and plants, avoid uncontrolled release to environment
Regulatory Ecological Status: Not classified as marine pollutant for transport, but should be handled to minimize ecological damage
Waste Treatment Methods: Incinerate in approved hazardous waste facility, do not discharge to sewer or environment
Hazardous Waste Regulations: Dispose according to local, regional, and national hazardous waste laws
Container Disposal: Rinse empty containers with water and solvent, dispose as hazardous waste, do not reuse for other chemicals
Storage before Disposal: Store waste in corrosion-resistant containers, clearly labeled and kept secure until transported for proper disposal
Other Disposal Precautions: Chemical must not enter water courses, do not mix with incompatible substances prior to disposal
UN Number: 2810
Proper Shipping Name: Toxic Liquid, Organic, n.o.s. (contains 2-Nitroanisole)
Hazard Class: 6.1 (Toxic substances)
Packing Group: III (Low danger)
Labeling Requirements: Toxic, consult transport regulations
Special Provisions: Avoid heat, direct sunlight, mechanical shock; containers must be tightly closed and leakproof
Environmental Hazards: Not marine pollutant, but take emergency action to prevent spillage during transit
Transport in Bulk: Not recommended except in dedicated, suitable containers with proper hazard signage
Occupational Safety: Subject to workplace control under OSHA Hazard Communication rules (29 CFR 1910.1200), proper MSDS must accompany all shipments
Chemical Inventory Listing: Found on TSCA inventory, regulated in EU under REACH Annex XVII restrictions, covered in similar chemical regulatory registries worldwide
Labeling Requirements: GHS-compliant pictograms and warning phrases
Carcinogen Status: IARC class 2B; not currently listed as confirmed carcinogen by NTP or OSHA, but precaution warranted
Reportable Quantity (RQ): Not assigned a specific RQ under CERCLA, handle using best-practice protocols for aromatic nitro compounds
Other Laws: Regulations on quantities stored, used, and released may apply at federal, state, and local levels; regular review of changing regulations highly advised for handlers and employers
