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Product Name: 2-Nitro-4-Toluidine
Chemical Formula: C7H8N2O2
Molecular Weight: 152.2 g/mol
CAS Number: 99-55-8
Synonyms: 4-Methyl-2-nitroaniline, para-methyl ortho-nitroaniline
Recommended Use: Dye intermediate, organic synthesis
Manufacturer Contact: Company name, address, phone number
Emergency Phone Number: Chemtrec, local applicable emergency response number
Classification: Acute toxicity (Oral, Dermal, Inhalation), Skin Sensitizer, Eye Irritation, Aquatic Hazard
Signal Word: Warning
GHS Labels: Skull and crossbones, exclamation mark, aquatic toxicity
Hazard Statements: Toxic if swallowed, causes skin irritation, may cause allergic skin reaction, causes serious eye irritation, toxic to aquatic life with long lasting effects
Precautionary Statements: Avoid contact with skin and eyes, wash thoroughly after handling, wear protective gloves/protective clothing/eye protection/face protection, avoid release to the environment, do not eat, drink or smoke when using this product
Chemical Name: 2-Nitro-4-Toluidine
Concentration: ≥99% by weight
Impurities: May contain minor amounts of related aromatic amines or nitro derivatives due to technical manufacturing processes
Additives: None identified
Inhalation: Move person to fresh air, maintain breathing, seek medical attention if symptoms persist or appear
Skin Contact: Remove contaminated clothing, wash thoroughly with soap and water, seek medical advice for persistent irritation or allergic reaction
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, remove contact lenses if present and easy to do, seek medical attention
Ingestion: Rinse mouth, do not induce vomiting, administer water if conscious, seek immediate medical assistance
Symptoms/Effects: Burning sensation, headache, nausea, respiratory irritation, allergic reactions, possible cyanosis
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Unsuitable Media: Strong water jets can spread contamination
Specific Hazards: Emits toxic fumes such as nitrogen oxides and carbon monoxide during combustion
Special Protective Equipment: Wear positive pressure self-contained breathing apparatus and full protective gear
Firefighting Instructions: Isolate area, keep upwind, use water spray to cool containers exposed to fire, minimize spread of runoff
Personal Precautions: Evacuate unprotected personnel, avoid skin and eye contact, prevent inhalation of dust
Protective Equipment: Use respirator, chemical-resistant gloves, eye protection, and protective clothing
Environmental Precautions: Prevent release to sewers, waterways, or soil
Containment and Cleanup: Cover spill with inert absorbent material, scoop into suitable labeled container, avoid generating dust, ventilate area, wash contaminated surfaces with water and detergent
Handling: Avoid breathing dust or vapor, use only with adequate ventilation, avoid contact with skin and eyes, use proper personal protective equipment, wash hands before breaks or eating, keep away from food and beverages
Storage: Store in tightly closed container in dry, cool, well-ventilated place, keep away from incompatible materials such as strong oxidizers and reducing agents, protect from direct sunlight and moisture conditions, clearly label storage area for hazardous chemicals
Engineering Controls: Use local exhaust ventilation or process enclosure to minimize exposure
Eye Protection: Chemical safety goggles or face shield
Skin Protection: Gloves made of nitrile or neoprene, lab coat or apron, closed footwear
Respiratory Protection: Approved particulate respirator in cases of insufficient ventilation or dust generation
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing and wash before reuse, avoid direct skin contact
Appearance: Yellow to orange crystalline solid
Odor: Slight aromatic or amine-like
Odor Threshold: Not determined
pH: Not available
Melting Point: 109–112 °C
Boiling Point: 350 °C at 760 mmHg
Flash Point: Not available
Flammability: Not classified as flammable
Vapor Pressure: Very low at room temperature
Solubility: Slightly soluble in water, soluble in ethanol, ether, and benzene
Partition Coefficient (log Kow): Data unavailable
Decomposition Temperature: Data unavailable
Viscosity: Not applicable
Density: 1.28 g/cm³ at 20°C
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not indicative of hazardous reactivity under normal use
Conditions to Avoid: High temperatures, sparks, open flames, sources of ignition, moisture
Materials to Avoid: Strong acids, strong bases, strong oxidizing and reducing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, possibly toxic amine and nitro compounds
Potential Acute Effects: Harmful if swallowed, irritant to skin and eyes, potential respiratory irritant
Chronic Exposure: May cause sensitization by skin contact, effects on blood (methemoglobinemia), possible risk of cancer based on amine classification
LD50 (Oral Rat): Approximately 100–500 mg/kg, indicating moderate to high toxicity
LD50 (Dermal Rabbit): Approx. 600–800 mg/kg
Likely Routes of Exposure: Inhalation, ingestion, eye or skin contact
Symptoms: Cyanosis, dizziness, headache, nausea, irritation, allergic response
Acute Toxicity: Highly toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: May not easily degrade, persistent under some conditions
Bioaccumulative Potential: Potential for bioaccumulation in aquatic organisms
Mobility in Soil: Limited mobility due to low water solubility
Other Adverse Effects: Harmful impact on microorganisms and lower aquatic life, risk of contamination for surface and groundwater through improper disposal
Waste Disposal Methods: Dispose of in accordance with local, regional, and national regulations, incineration in authorized facility preferred, do not discharge to surface water or sewage
Contaminated Packaging: Empty containers retain product residue, treat as hazardous waste, triple rinse and puncture before recycling or disposal
Other Disposal Recommendations: Consult with hazardous waste disposal specialists or local environmental authorities for proper procedures, do not attempt disposal by dilution or evaporation
UN Number: 1661
UN Proper Shipping Name: 2-Nitro-4-Toluidine
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Environmental Hazards: Marine pollutant, toxic to aquatic life
Special Precautions for User: Avoid direct contact, ensure containers are tightly closed and properly labeled, transport separately from foods and animal feeds, emergency schedule (EmS) and transport documentation as per regional and international regulations
Safety, Health, and Environmental Regulations Specific for the Substance: Subject to reporting under EPA SARA Title III and CERCLA for hazardous chemical inventory
OSHA: Listed as hazardous under Occupational Safety and Health Administration guidelines
TSCA: Listed in the Toxic Substances Control Act Inventory
EU Regulations: Classified as hazardous, subject to REACH Annex XVII restrictions for hazardous amines
Other Requirements: Proper labeling, restricted workplace exposure, use of engineering and PPE controls, regular safety training for personnel handling the product, National and local limits for air, water, and soil contamination, compliance with international transport standards (IATA/ICAO, IMDG, ADR)
