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Product Name: 2-Nitro-4-Cresol
Synonyms: 4-Hydroxy-2-nitrotoluene, p-Cresol, 2-nitro-
CAS Number: 99-54-7
Molecular Formula: C7H7NO3
Manufacturer: Provided by chemical supplier, contact information typically found on container label
Emergency Phone Number: Chemtrec: 1-800-424-9300
Recommended Use: Laboratory chemical, research and development
Restrictions: Not for food, drug, or household use
GHS Classification: Acute toxicity (oral, dermal), Skin corrosion/irritation, Eye damage/irritation, Specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, suspected of causing genetic defects
Symbol: Exclamation mark, Health hazard
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Symptoms: Irritation, headache, dizziness, nausea, possible methemoglobinemia
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves and eyewear
Chemical Name: 2-Nitro-4-Cresol
CAS Number: 99-54-7
EC Number: 202-763-0
Purity: Typically >98%
Impurities: Trace toluene derivatives, unspecified
Ingredient Status: Single substance
Inhalation: Remove from exposure. Move person to fresh air. Seek medical attention if respiratory symptoms appear.
Skin Contact: Remove contaminated clothing, rinse affected area with plenty of water for at least 15 minutes. Wash with soap and water. Medical attention suggested for persistent irritation.
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes, making sure to keep eyelids open. Immediate medical help is critical if irritation persists.
Ingestion: Rinse mouth, do not induce vomiting unless directed. Immediate medical attention critical. Observe for symptoms such as dizziness, vomiting, or confusion.
Notes to Physician: Provide symptomatic and supportive treatment. Observe for signs of methemoglobinemia.
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide. Avoid direct water jet to avoid dust spread.
Specific Hazards: During heating or fire, toxic vapors such as nitrogen oxides and carbon monoxide can be released.
Protective Equipment: Firefighters need self-contained breathing apparatus and protective clothing.
Fire Response: Remove containers from danger zone if not at risk. Cool adjacent containers with water spray. Stay upwind and prevent runoff into drains.
Combustion Products: Carbon oxides, nitrogen oxides, phenolic compounds.
Personal Precautions: Keep unauthorized personnel away. Wear appropriate protective gear, such as gloves, goggles, respirator.
Environmental Precautions: Prevent further spillage or leakage if safe. Do not allow material to reach sewers or water systems.
Containment and Cleanup: Use inert absorbent for small spills. Sweep up and place in suitable containers for proper disposal. Wash contaminated surface with soap and water.
Methods for Disposal: Dispose of as hazardous chemical waste. Provide adequate ventilation during cleanup.
Precautions for Safe Handling: Avoid contact with skin, eyes and clothing. Do not breathe dust or fumes. Wash hands thoroughly after handling.
Storage Conditions: Store in tightly closed containers in a cool, dry, well-ventilated place away from incompatible substances, such as strong oxidizers or bases.
Safe Handling Note: Handle only in fume hood or controlled environments with suitable personal protective equipment.
Incompatibilities: Avoid contact with acids, alkalis, and powerful oxidants.
Other Storage Info: Store at room temperature, shielded from direct sunlight, away from heat sources.
Occupational Exposure Limits: No ACGIH or OSHA values specifically listed for this compound. Use similar precautions as for nitrophenols or cresols.
Ventilation: Use with local exhaust and general ventilation, preferably within a fume hood.
Personal Protection: Wear chemical-resistant gloves (nitrile recommended), safety goggles, lab coat or similar protective clothing, and in dusty situations NIOSH/OSHA-approved respirator.
Hygiene Measures: Wash thoroughly after handling. Do not eat, drink, or smoke during use.
Contaminated Clothing: Remove and wash contaminated clothing before reuse.
Appearance: Pale yellow to yellow-brown crystalline powder
Odor: Phenolic, slightly sharp
Odor Threshold: Not determined
pH: 5-6 (0.1% solution in water)
Melting Point: 105–110°C
Boiling Point: Decomposes before boiling
Flash Point: Not established, expected to be over 110°C
Flammability: Not highly flammable but may burn under specific conditions
Vapor Pressure: Negligible at room temperature
Solubility: Slightly soluble in water, more soluble in organic solvents such as ethanol, ether
Partition Coefficient (log Kow): 1.91
Decomposition Temperature: Decomposes ≥ 200°C
Density: 1.35 g/cm³ (approximate)
Chemical Stability: Stable under normal temperature and pressure with proper storage.
Reactivity: Can react with strong acids, strong bases, and oxidizing agents.
Hazardous Decomposition: Emits toxic fumes of nitrogen oxides and carbon oxides when heated strongly.
Possibility of Hazardous Reactions: No hazardous polymerization expected. Violent reaction with strong oxidants possible.
Conditions to Avoid: High temperatures, sparks, open flames, incompatible chemicals.
Acute Toxicity: Oral LD50 (rat): 600 mg/kg. Data for similar cresol derivatives support this range.
Chronic Effects: Repeated or prolonged contact may cause organ damage, primarily affecting blood, kidneys, or liver.
Carcinogenicity: No IARC, NTP, or OSHA listings; not classed as carcinogen, but evidence of mutagenic effects in some studies.
Irritation: Causes skin and eye irritation. Can cause respiratory tract irritation if inhaled.
Sensitization: No confirmed sensitization data but potential as with phenolic agents.
Target Organs: Blood, liver, kidneys, skin, eyes.
Aquatic Toxicity: Harmful to aquatic life. Estimated LC50 (fish, 96hr): as low as 5–10 mg/L.
Persistence and Degradability: Slowly degradable. Contains nitro and cresol groups resistant to rapid breakdown.
Bioaccumulation Potential: Log Kow suggests moderate bioaccumulation.
Mobility in Soil: Limited mobility due to partial water solubility.
Other Adverse Effects: Toxic to aquatic organisms, possible risk of long-term adverse effects.
Disposal Methods: Dispose of contents according to federal, state, and local environmental regulations. Do not drain into sewers or allow to reach waterways.
Container Disposal: Empty containers must be handled as hazardous, triple rinsed, or incinerated by licensed waste contractor.
Sewage Disposal: Prohibited.
Recycling or Reuse: Not advised due to toxicity and contamination risk.
UN Number: Not assigned for this compound. For similar nitrophenols, check as UN 1663, Toxic solid, organic.
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Shipping Name: Toxic solid, organic, n.o.s. (contains 2-Nitro-4-Cresol)
Marine Pollutant: Yes
Labels Required: Toxic, Keep Away From Foodstuffs
Special Precautions: Keep away from incompatible materials and moisture. Ensure containers are sealed and upright.
TSCA Status: Listed
REACH Status: Not registered; research use exemptions possible.
SARA Title III (Sections 302/313): Not listed as extremely hazardous, but similar nitro-aromatic compounds may be regulated.
California Proposition 65: Not specifically listed
WHMIS Classification (Canada): D1B - Toxic Material, D2B - Irritant
Hazard Symbols: Xn (Harmful), Xi (Irritant)
Inventory Status: Listed in most major chemical inventories worldwide
