© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Chemical Name: 2-Fluoroaniline
Chemical Formula: C6H6FN
CAS Number: 348-54-9
Molecular Weight: 111.12 g/mol
Physical Form: Usually shows up as a slightly yellowish liquid, with a distinct, unpleasant odor. Even at room temperature, it can get to the nerves just from a whiff. Volatile organic compounds like this leave their mark not only in the test tube but in the air around us, so inhalation becomes a real issue for anyone nearby.
Main Hazards: Toxic by inhalation and skin absorption, and can cause severe irritation to skin, eyes, and respiratory system. Exposure can bring headaches, nausea, and even more severe symptoms like liver or kidney distress after heavier contact. Vapors may affect the central nervous system. A splash into the eyes can lead to lasting damage. Classified as harmful if swallowed. People handling it know it’s flammable, which adds a layer of worry where heat or sparks exist.
Substance: 2-Fluoroaniline
Purity: Typically above 98% in scientific settings, the main risk stems from the compound itself rather than impurities. No stabilizers or additives commonly present. You’re dealing straight with the chemical; what you see is what you get.
Inhalation: Remove the person to fresh air immediately. If breathing becomes labored, oxygen support often enters the conversation. Medical attention can’t wait.
Skin Contact: Take off contaminated clothing right away and soak the affected area with water for at least fifteen minutes.
Eye Contact: Rinse with plenty of water, holding eyelids open. The burning and risk of permanent damage push this up the urgency scale.
Ingestion: Do not trigger vomiting. Rinse mouth and drink water if possible and get medical help without delay.
Suitable Extinguishing Agents: Dry chemical, foam, or carbon dioxide step up best. Water only to cool containers, not for direct fire attack.
Specific Hazards: Toxic fumes like hydrogen fluoride and nitrogen oxides blow off during combustion. Firefighters face risk from both heat and toxic exposure.
Protective Equipment: Self-contained breathing apparatus and full protective clothing are the usual gear in a fire—a reminder that chemical fires rarely match typical fires in risk.
Personal Precautions: Respiratory protection and chemical-resistant gloves stand between the handler and lasting health effects. Ventilation is key; don’t let fumes linger. Avoid skin contact and block access to the affected area.
Containment: Absorb small spills with inert material (like sand or vermiculite). Shovel into containers for disposal. Larger releases call for professional cleanup due to vapor and toxicity.
Environment: Prevent runoff into drains and waterways, as this compound carries risks for aquatic life.
Handling: Always use with local exhaust or outdoors, under a fume hood. Extended skin, eye, and lung exposure can’t be underestimated. No eating, drinking, or smoking in the area. Contamination on surfaces or clothing brings risk long after a shift ends.
Storage: Keep sealed in a cool, well-ventilated space away from heat and ignition sources. Store separately from oxidizers and acids, as reactions can lead to fire or gas release. Ventilate storage spaces well to prevent vapor build-up.
Engineering Controls: Fume hoods or other mechanical ventilation become non-negotiable in any lab or plant where this is used.
PPE: Splash goggles or face shields defend against splashes. Gloves made from nitrile or neoprene hold up best. Lab coats and aprons keep the chemical off your skin, and, for higher-risk work, a respirator designed for organic vapors proves its worth fast.
Exposure Limits: Not always formally established, but guidelines for similar anilines or fluorinated aromatics should drive workplace monitoring.
Appearance: Light yellow to colorless oily liquid.
Odor: Sharp and pungent, alerts most folks immediately.
Boiling Point: Around 182°C
Melting Point: Roughly 2°C
Solubility: Slightly soluble in water, but mixes well with most organic solvents.
Vapor Pressure: Noticeably volatile at room temperature, so airborne release is a clear concern.
Flash Point: Usually falls near 65°C, below many hot process lines.
Stability: Keeps stable in recommended storage, but prolonged light or air exposure can yield hazardous decomposition products.
Reactivity: Reacts with strong oxidizers, acids, and acid chlorides. Mixing with these brings heat, gas, or even fire risk.
Acute Toxicity: Toxic by ingestion, inhalation, or skin absorption. Reported LD50 in rats—ranging around several hundred milligrams per kilogram—reminds us that even small amounts can cause severe harm.
Symptoms: Headache, dizziness, methemoglobinemia, and, with higher exposures, collapse or organ injury.
Chronic Risks: Repeated contact may affect blood, liver, and kidneys. Some aromatic amines have connections to long-term cancer risks, so this isn’t a chemical for shortcuts or guesswork in the lab or plant.
Aquatic Toxicity: Harmful to fish and aquatic invertebrates after release. Persistent in water and can travel fast.
Soil Fate: Tends to resist natural breakdown, so contamination from a spill could hang around. Improper disposal sends a downstream risk into both local soils and broader water systems.
Bioaccumulation: Little direct data, but the structure gives reason to think build-up in the food chain is possible if releases keep happening.
Chemical Waste Handling: Collection in closed, labeled containers designed for hazardous waste is the safe bet. On-site neutralization is not typical since incomplete reactions risk unsafe residues.
Incineration: High-temperature incineration at government-approved plants is the safest approach. Landfill or drain disposal is not an option for anything besides trace contamination from packaging, and even that is rarely advised. Treating it lightly kicks the risk down the line to groundwater, wildlife, and people who never signed up for it.
UN Number: 2733 (for aniline derivatives with similar properties)
Class: Toxic substance
Packing Group: III, for lower immediate hazard but still requiring strict controls during transport.
Proper Shipping Name: 2-Fluoroaniline
Special Precautions: Packaging designed to prevent leaks or vapor build-up, with clear hazard labels. Shipping containers stay secured upright, away from potential impacts or sources of heat.
Lab and Workplace Limits: Occupational health agencies suggest similar tight limits as for aniline and related substances—skin, inhalation, and eye contact need minimizing.
Right-to-Know Laws: Facilities using this chemical answer to governments with strict reporting requirements.
Environmental Regulations: Restrictions or bans on water discharge in regions with strong chemical management policies. Waste tracking and documentation laws make sure disposal doesn’t skip any steps.
Worker Safety: Hazard communication standards like training, labeling, and documentation protect not just scientists, but also support staff and anyone who comes near storage or disposal areas.
