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Chemical Name: 2-Bromotoluene
Synonyms: o-Bromotoluene, ortho-Bromotoluene
Chemical Formula: C7H7Br
Molecular Weight: 171.04 g/mol
CAS Number: 95-46-5
Recommended Use: Used as an intermediate in organic synthesis, especially agrochemicals, pharmaceuticals, and dyes
Manufacturer Details: Supplied by chemical manufacturers to research labs and industry
Emergency Contact: Refer to local emergency numbers and manufacturer contacts for chemical incidents
Relevant Restrictions: Not intended for food, drug, or household applications; for laboratory and industrial use only
GHS Classification: Flammable Liquids (Category 3); Acute Toxicity/Inhalation (Category 4); Skin Irritation (Category 2); Eye Irritation (Category 2A)
Pictograms: Flame, Exclamation mark
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor; harmful if inhaled; causes skin irritation; causes serious eye irritation
Precautionary Statements: Keep away from heat, sparks, open flames; no smoking; avoid breathing vapor; use protective gear
Potential Health Effects: Short-term exposure leads to irritation of skin, eyes, and respiratory system; vapor inhalation may induce dizziness, headache, or nausea; prolonged skin contact may cause dermatitis
Environmental Hazards: Toxic to aquatic life with long-lasting effects; prevent release into environment
Chemical Component: 2-Bromotoluene
Concentration: Greater than 98%
Impurities: May contain trace toluene or other brominated benzenes
Stabilizers or Additives: Usually provided neat, without stabilizers
CAS Number: 95-46-5
EC Number: 202-422-2
Other Identifiers: Listed in inventories of the U.S., EU, and Asian territories as a recognized chemical
Inhalation: Move affected person to fresh air immediately; keep at rest and seek medical attention if respiratory symptoms persist or worsen; provide oxygen if breathing becomes difficult
Skin Contact: Remove contaminated clothing; rinse skin thoroughly with water and mild soap for at least 15 minutes; seek medical advice for persistent redness or irritation
Eye Contact: Rinse cautiously with plenty of water for 15 minutes, reducing risk of additional injury; remove contact lenses if present and easy to do; seek immediate medical attention, especially if irritation persists
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical advice promptly; never give anything by mouth to an unconscious person
Main Symptoms/Effects: Irritation of skin, eyes, respiratory system; dizziness, headache, nausea after vapor inhalation; risk of chemical pneumonitis if aspirated
Immediate Medical Attention: Always call poison center or doctor for significant exposures
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, carbon dioxide; use water spray to cool containers, but direct jets may spread material
Unsuitable Extinguishing Media: Do not use high-stream water jets directly on the product
Specific Hazards: Releases toxic fumes under fire conditions, such as hydrogen bromide, carbon oxides; highly flammable liquid and vapor, with risk of explosion from vapor/air mixtures
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear; keep unnecessary personnel away
Special Firefighting Procedures: Dike fire-control water for later disposal; ventilate area after fire-fighting
Additional Information: Containers exposed to fire may rupture explosively; remove them if safe to do so
Personal Precautions: Evacuate all unnecessary personnel; ventilate area; use personal protective equipment including gloves, goggles, and respirators
Environmental Precautions: Prevent spill from entering drains, watercourses, or soil; alert environmental authorities if spill crosses environmental thresholds
Containment Procedures: Stop leak if safe; dike spill with inert absorbent materials like sand or vermiculite; prevent further leakage or spillage
Cleanup Methods: Collect absorbed material in labeled waste containers; wash spill area with large amounts of water; ventilate site to remove vapors
Other Advice: Eliminate ignition sources such as open flames or static discharge; ensure proper waste disposal through licensed chemical waste contractors
Handling: Work with adequate ventilation; wear eye protection, lab coat, and gloves; ground containers and equipment; avoid breathing vapor and contact with skin or eyes; use non-sparking tools
Storage: Store in a tightly closed container in a cool, dry, well-ventilated place away from heat and ignition sources; segregate from acid chlorides, strong oxidizers, and strong bases; keep away from food and animal feed
Storage Stability: Ensure storeroom temperature remains below 30°C (86°F); check regularly for container leaks
Special Requirements: Label containers clearly; implement inventory control and rotation; store only in approved containers; practice good housekeeping to limit vapor buildup
Occupational Exposure Limits: No OSHA, ACGIH, or NIOSH exposure limits established for 2-Bromotoluene; consult local occupational guidelines
Engineering Controls: Use local exhaust ventilation, fume hoods, or equivalent for direct handling and transfers; monitor airborne concentrations periodically
Personal Protective Equipment: Nitrile or neoprene gloves, chemical safety goggles, flame-resistant lab coat
Respiratory Protection: Use NIOSH-approved respirators if engineering controls are insufficient; appropriate filter cartridges for organic vapors
Skin Protection: Use chemical-resistant gloves and splash protection; avoid skin contact by minimizing exposure through good work practices
Hygiene Practices: Wash thoroughly after handling; avoid eating, drinking, or smoking around chemical; launder contaminated clothing before reuse
Appearance: Colorless to pale yellow liquid
Odor: Aromatic, benzene-like scent
Odor Threshold: Not determined
pH: Not applicable (neutral organic liquid)
Melting Point/Freezing Point: -23°C
Boiling Point/Range: 184–186°C
Flash Point: 68°C (closed cup)
Evaporation Rate: Not determined
Flammability: Flammable liquid and vapor
Upper/Lower Flammability: Lower explosion limit 1.1%, upper limit 7.3% (in air)
Vapor Pressure: 1.0 mmHg @ 25°C
Vapor Density: 5.9 (air = 1)
Relative Density: 1.39 (water = 1)
Solubility: Insoluble in water; soluble in organic solvents like ether and ethanol
Partition Coefficient (n-octanol/water): 3.8
Auto-ignition Temperature: 535°C
Decomposition Temperature: Not available
Viscosity: Not determined
Chemical Stability: Stable under standard conditions; avoid prolonged exposure to light and high temperatures
Reactive Materials: Strong oxidizing agents, acid chlorides, strong bases can react violently or cause decomposition
Hazardous Decomposition: Bromine compounds, hydrogen bromide, carbon monoxide, carbon dioxide under fire or decomposition
Hazardous Polymerization: Does not polymerize under normal conditions
Conditions to Avoid: Heat, sources of ignition, incompatible materials
Other Reactivity Notes: May slowly degrade in open air with light exposure
Acute Toxicity: Oral LD50 (rat) estimated around 4000 mg/kg; not acutely lethal at expected exposure levels, but precautions remain necessary
Skin Corrosion/Irritation: Causes moderate irritation after direct contact; prolonged or repeated contact may cause dryness or cracking
Serious Eye Damage/Irritation: Causes significant irritation, possible temporary injury
Respiratory Sensitization: No evidence reported, but inhalation of concentrated vapor can lead to respiratory discomfort
Carcinogenicity: No component listed by IARC, NTP, or OSHA as a known carcinogen
Reproductive Toxicity: No definitive evidence of mutagenic or reproductive effects; insufficient long-term studies
Other Effects: May be absorbed through skin in small amounts; central nervous system depression possible at high exposures
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in aquatic environment; presence in water should be prevented
Persistence and Degradability: Not readily biodegradable in standard tests; persists in sediment and water
Bioaccumulative Potential: Partition coefficient indicates potential for bioaccumulation in aquatic organisms
Mobility in Soil: Low solubility limits leaching, but vapor can migrate if released
Other Adverse Effects: Avoid direct release to environment due to toxicity to fish and invertebrates
Ecological Data: Specific LC50 data scarce, but by analogy to related halogenated aromatics, risk to small aquatic life is notable
Product Disposal: Treat as hazardous waste; incinerate in chemical incinerator equipped with afterburner and scrubber; comply with local, regional, and national regulations
Container Disposal: Triple rinse empty containers; puncture and dispose through approved chemical waste processors
Precautions for Disposal: Prevent material from entering sewers, storm drains, or watercourses during disposal
Reuse Recommendations: Do not attempt to clean for reuse if contaminated
RCRA Waste Code: Consult authority for local classification, but halogenated organics often regulated as hazardous
UN Number: UN1993
Proper Shipping Name: Flammable liquid, n.o.s. (2-Bromotoluene)
Hazard Class: 3 (Flammable Liquids)
Packing Group: III
Labels Required: Flammable Liquid
Marine Pollutant: Yes, according to IMDG
Transport Considerations: Avoid rough handling and physical damage; keep away from food, feed, oxidizers; store and transport in upright, secure containers
Special Precautions: Emergency response guides should accompany shipments; responders need spill and fire procedure training for hazardous chemical transport
U.S. TSCA: Listed in Toxic Substances Control Act Inventory
OSHA Hazard: Classified as hazardous chemical
SARA Title III: Not listed as extremely hazardous, but report spills over reportable quantities
EPCRA: Not listed under Section 313 for special reporting
European Union: Classified as flammable and irritant under CLP; REACH registered and subject to standard handling and notification
Other International Regulations: Australia (AICS), Canada (DSL/NDSL), Japan (ENCS); present on most global inventories
Waste Legislation: Disposal subject to local and national environmental regulations; halogenated compounds often require specialist treatment or incineration
