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Product Name: 2-Bromobutane
Chemical Formula: C4H9Br
Synonyms: sec-Butyl bromide
CAS Number: 78-76-2
Recommended Use: Laboratory chemical, pharmaceutical intermediate, organic synthesis
Manufacturer: Refer to your procurement documentation
Contact Information: Emergency telephone details included on packaging
UN Number: 2344
GHS Classification: Flammable liquids (Category 3), Acute toxicity oral (Category 4), Acute toxicity dermal (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A)
Label Elements: Flame, Exclamation mark
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Harmful if swallowed, in contact with skin, or inhaled. Causes skin and eye irritation. May cause respiratory irritation.
Precautionary Statements: Keep away from heat, sparks, open flames. Avoid breathing vapors or mists. Wear protective gloves and eye protection.
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Substance: 2-Bromobutane
CAS Number: 78-76-2
Content: >99% by weight
Impurities: Potentials include traces of 1-bromobutane, water, and organic residues from synthesis
Inhalation: Move exposed person to fresh air. Maintain open airway. For persistent symptoms like coughing or dizziness, seek medical attention.
Skin Contact: Immediately remove contaminated clothing. Rinse skin thoroughly with soap and water. Seek medical evaluation if irritation persists.
Eye Contact: Rinse cautiously with water for at least 15 minutes, holding eyelids open. Remove contact lenses if present and easy to do. Call for medical care if pain, redness, or blurred vision lasts.
Ingestion: Rinse mouth with water. Do not induce vomiting. If feeling unwell or if ingestion was significant, consult medical personnel right away.
Most Important Symptoms/Effects: Skin irritation, eye damage, respiratory discomfort, abdominal pain, headache
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water mist
Specific Hazards: Vapors can form explosive mixtures with air. Combustion produces hydrogen bromide, carbon oxides, and other toxic gases.
Protective Equipment: Firefighters use self-contained breathing apparatus, full protective gear
Special Procedures: Use water spray to cool containers exposed to fire. Prevent runoff to sewers.
Personal Precautions: Evacuate unprotected personnel. Avoid vapor inhalation. Provide ventilation. Wear suitable PPE—gloves, eye protection, lab coat.
Environmental Precautions: Prevent spillage from entering drains, soil, or water sources. Notify authorities if environmental contamination occurs.
Methods for Clean-Up: Absorb with inert material like sand or vermiculite. Place in a suitable closed chemical waste container. Clean contaminated area with water and detergent.
Handling: Keep away from ignition sources. Use non-sparking tools and explosion-proof equipment. Avoid inhalation and contact with skin, eyes, or clothing. Work under fume hood.
Storage: Store in cool, dry, well-ventilated area in tightly closed containers. Keep containers upright, away from incompatible materials such as strong oxidizing agents. Use approved flammable chemical storage cabinets. Protect from sunlight and heat sources.
Engineering Controls: Use in chemical fume hood. Ensure safety showers and eyewash stations are accessible. Maintain good general ventilation.
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile recommended), safety goggles or face shield, flame-resistant laboratory coat. For large volumes, use respiratory protection with organic vapor cartridge.
Hygiene Measures: Wash hands thoroughly after handling. Do not eat, drink, or smoke in work area.
Occupational Exposure Limits: No established threshold limit value (TLV) for 2-bromobutane. Follow local guidelines.
Appearance: Colorless to pale yellow liquid
Odor: Sweet, ether-like
Molecular Weight: 137.02 g/mol
Boiling Point: 91–93°C (195–199°F)
Melting Point: –112°C (–170°F)
Flash Point: 17°C (63°F), closed cup
Autoignition Temperature: 450°C (842°F)
Vapor Pressure: 55 mm Hg at 20°C
Solubility: Insoluble in water. Soluble in ethanol, ether, and chloroform.
Density: 1.25 g/cm3 at 20°C
Viscosity: Not available
Partition Coefficient: log Pow = 2.28
Chemical Stability: Stable under recommended storage conditions
Reactivity: May react violently with strong oxidizers, alkali metals, and strong bases. Vapors form flammable mixtures with air.
Hazardous Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide
Conditions to Avoid: Heat, flames, sparks, strong sunlight, incompatible chemicals
Polymerization: Not reported under normal conditions
Acute Toxicity: Oral rat LD50 approximately 1,800 mg/kg. Inhalation LC50 information limited. Harmful if swallowed, inhaled, or absorbed through skin.
Skin Corrosion/Irritation: Results in redness and dryness upon repeated contact
Serious Eye Damage/Irritation: Exposure leads to pain, watering, possible temporary injury
Respiratory Sensitization: Vapor inhalation causes throat irritation, coughing, short breath
Chronic Effects: Prolonged contact could increase risk of dermatitis
Other Information: Not considered carcinogenic, mutagenic, or a reproductive toxin by current classification criteria
Toxicity to Aquatic Life: Moderate toxicity toward aquatic organisms. LC50 (fish, 96 hr): >10 mg/L estimated
Persistence and Degradability: Not easily biodegradable, slow breakdown in soil and water
Bioaccumulative Potential: Expected to bioaccumulate in aquatic species based on log Pow value
Mobility in Soil: Low, due to hydrophobic nature
Other Adverse Effects: Harmful impact if released in significant quantities.
Disposal Methods: Collect waste into sealed, clearly labeled containers. Dispose as hazardous waste through licensed chemical disposal contractor.
Contaminated Packaging: Rinse empty containers with an appropriate solvent. Containers retain product residues; dispose accordingly.
Local Regulations: Observe all regional, national, and international disposal regulations.
UN Number: 2344
Proper Shipping Name: 2-Bromobutane
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: II
Label: Flammable Liquid
Environmental Hazards: Not considered marine pollutant.
Special Precautions: Avoid shock, keep containers upright and secure during transport.
TSCA: Listed on the US Toxic Substances Control Act inventory
EINECS/ELINCS: Listed, EINECS No. 201-203-6
OSHA: Flammable liquid, regulated hazardous substance
WHMIS (Canada): B2 (flammable liquid), D2B (toxic)
REACH: Subject to European REACH regulation requirements
Other National Regulations: Product classified and labeled in accordance with EC Directives and respective national laws.
