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Product Name: 2-Bromobenzoyl Chloride
SYNONYMS: o-Bromobenzoyl chloride, 2-bromobenzenecarbonyl chloride
CAS No.: 4219-25-0
Formula: C7H4BrClO
Company Identification: (Manufacturer and supplier details, including address, contact number, and emergency phone number provided by supplier)
Recommended Uses: Used in organic synthesis, chemical research, and pharmaceutical intermediates
GHS Classification: Acute Toxicity (Inhalation) Category 3, Skin Corrosion/Irritation Category 1B, Eye Damage/Irritation Category 1, Specific Target Organ Toxicity Single Exposure Category 3
Label Elements: Danger; toxic if inhaled, causes severe skin burns and eye damage, may cause respiratory irritation
Hazard Statements: H331: Toxic if inhaled, H314: Causes severe skin burns and eye damage, H335: May cause respiratory irritation
Precautionary Statements: Wear protective gloves/protective clothing/eye protection/face protection, avoid breathing dust/fume/gas/mist/vapors/spray, use only outdoors or in a well-ventilated area, wash skin thoroughly after handling
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Chemical Name: 2-Bromobenzoyl Chloride
CAS Registry Number: 4219-25-0
Concentration: 98-100% by weight
Inhalation: Move the affected person into fresh air, keep comfortable for breathing, seek medical attention, administer oxygen if breathing is difficult
Skin Contact: Immediately remove contaminated clothing, rinse skin with large amounts of water for at least 15 minutes, seek medical help
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing while calling for immediate medical help
Ingestion: Do not induce vomiting, rinse mouth thoroughly with water, never give anything by mouth to an unconscious person, get medical attention
Suitable Extinguishing Media: Dry sand, carbon dioxide, dry chemical powder, do not use water directly on material
Specific Hazards: Releases hydrogen chloride, bromine, and phosgene gases upon burning or contact with water
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear. Approach from upwind and avoid low lying areas, as heavy vapors may accumulate
Combustion Products: Carbon oxides, hydrogen chloride, bromide fumes, phosgene
Decomposition Hazards: Decomposes on heating or contact with moisture, producing toxic and corrosive fumes
Personal Precautions: Evacuate all non-essential personnel, ventilate area, avoid skin and eye contact, wear chemical-resistant gloves, safety goggles, and protective clothing
Environmental Precautions: Prevent entry into sewers, drains, or watercourses, inform relevant authorities in case of environmental contamination
Cleanup Methods: Absorb spill with inert material such as dry earth or vermiculite, collect and place in suitable, labeled chemical waste container, do not allow contact with water or moist air
Decontamination: Clean contaminated surfaces thoroughly with dilute sodium bicarbonate solution, rinse area with plenty of clean water while monitoring for corrosive residues
Handling: Work in chemical fume hood, avoid inhalation of vapors, prevent contact with skin, eyes, and clothing, use only with proper exhaust ventilation, keep containers tightly closed
Storage: Store in cool, dry, well-ventilated area away from sources of moisture, heat, and incompatible substances such as strong bases and oxidizing agents, keep container tightly sealed and protected from light
Special Requirements: Segregate from acids, alkalis, oxidizers and amines. Use secondary containment to avoid accidental spills. Protect from physical damage
Engineering Controls: Use chemical fume hood, provide eyewash stations and safety showers in work area
Occupational Exposure Limits: No OSHA PEL or ACGIH TLV established
Personal Protection: Wear impervious gloves, chemical splash goggles, laboratory coat, and full-face respirator if ventilation is inadequate
Respiratory Protection: NIOSH/MSHA approved respirator suitable for organic vapors, chemical cartridge type for acid gases during spill or high exposure risk
Other Protection: Ensure thorough hand washing after handling, wash contaminated clothing before reuse
Appearance: Clear to pale yellow liquid
Odor: Sharp, pungent, lachrymatory
Molecular Weight: 219.47 g/mol
Boiling Point: 126-130°C at 10 mmHg
Melting Point: 13-15°C
Flash Point: Not available
Solubility: Reacts with water, soluble in organic solvents such as acetone, benzene, and chloroform
Vapor Pressure: Not determined
Density: 1.65 g/cm³
pH: Not applicable
Chemical Stability: Stable in dry, sealed containers under recommended storage conditions
Reactivity: Violently hydrolyzed by water or moist air producing hydrogen chloride and 2-bromobenzoic acid
Incompatible Materials: Water, strong bases, oxidizing agents, alcohols, amines
Hazardous Decomposition Products: Hydrogen chloride, bromide fumes, possible phosgene, corrosive acidic vapors
Conditions to Avoid: Exposure to moisture, high temperatures, contact with incompatible substances
Acute Toxicity: Harmful/toxic if inhaled, can cause severe respiratory irritation and lung edema, corrosive to skin and eyes with risk of permanent damage
Sensitization: No data available
Chronic Exposure: May aggravate pre-existing respiratory, skin, or eye conditions, repeated exposure produces dermatitis and respiratory symptoms
Carcinogenicity: Not listed by NTP, IARC, OSHA
LD50 (oral, rat): No published data
Symptoms of Over Exposure: Burning pain in nose, throat, and eyes, coughing, labored breathing, skin ulcers, eye injury, possible vomiting if ingested
Toxicity: Harmful to aquatic life due to acidity and reactivity
Persistence and Degradability: Hydrolyzes rapidly in presence of water, breakdown products may persist
Bioaccumulative Potential: No data available
Mobility in Soil: Expected to adsorb to soil based on chemical structure, not likely to leach significantly
Other Effects: Accidental discharge may cause localized pH elevation and harm aquatic organisms. Requires immediate containment and neutralization
Waste Treatment Methods: Collect residues and absorbents in labeled, leak-proof containers, neutralize cautiously with dilute sodium carbonate or alkaline agents in a controlled manner under a fume hood
Disposal of Contaminated Packaging: Rinse thoroughly, treat as hazardous waste, dispose of in accordance with local, state, federal, and national regulations
Environmental Precautions: Do not discharge into waterways, soil, or storm drains. Consult licensed waste contractor for proper disposal
UN Number: UN 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (2-Bromobenzoyl chloride)
Transport Hazard Class: 8, Corrosive
Packing Group: II
Label: Corrosive
Special Precautions: Avoid contact with moisture, keep containers upright and secure, conduct periodic inspection during transit, transport in compliance with national and international regulations
OSHA Status: Hazardous by definition of Hazard Communication Standard
TSCA Status: Listed
SARA Title III: Not subject to Section 313 reporting
REACH Status: Registration, evaluation, and authorization required for import into the European Union
Other Regulations: Subject to workplace labeling, hazard communication, and environmental protection laws. Requires proper training and compliance with chemical safety procedures for shipment, handling, and disposal
