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Product Name: 2-Bromo-2-Methylpropane
Synonyms: tert-Butyl bromide, t-Butyl bromide, tert-Butylbromid
Chemical Formula: C4H9Br
CAS Number: 507-20-0
Recommended Use: Chemical synthesis, laboratory reagent, organic intermediate
Manufacturer: Listed on container label
Contact Address: Refer to supplier’s details
Emergency Telephone Number: Provided by supplier on request
GHS Classification: Flammable liquids (Category 2); Skin irritation (Category 2); Eye irritation (Category 2A); Specific target organ toxicity - single exposure (Category 3); Acute aquatic toxicity (Category 2)
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor. Causes skin and eye irritation. May cause drowsiness or dizziness. Toxic to aquatic life.
Pictograms: Flame, exclamation mark, environment
Precautionary Statements: Keep away from ignition sources. Avoid breathing fumes or vapors. Wear protective gloves, clothing, and eye protection. Avoid release into the environment.
Other Hazards: No data for PBT or vPvB assessments. Vapors heavier than air and may travel along surfaces to distant ignition points.
Chemical Name: 2-Bromo-2-Methylpropane
Concentration: ≥98%
CAS Number: 507-20-0
EC Number: 208-066-4
Impurities or Stabilizing Additives: No relevant impurities at reported concentrations
Inhalation: Move exposed person to fresh air without delay. Seek medical attention if symptoms such as headache, dizziness, or respiratory discomfort appear.
Skin Contact: Take off contaminated clothing. Rinse skin with plenty of water for at least 15 minutes. Get medical advice if irritation persists or chemical burns develop.
Eye Contact: Flush immediately and continuously with water for at least 15 minutes, ensuring eyelids are held open. Remove contact lenses if possible. Obtain medical help at once.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly with water. Get immediate medical attention. Never give anything by mouth to someone who is losing consciousness.
Most Important Symptoms: Dizziness, headache, nausea, dermatitis, eye redness, tingling of skin.
Immediate Medical Attention Needed: Call for support if exposed in large amounts, or if symptoms develop or persist. Treatment is symptomatic.
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, carbon dioxide, or water spray for cooling.
Unsuitable Extinguishing Media: Direct water jet may cause chemical splatter.
Specific Hazards: Releases bromine-containing vapors, hydrogen bromide, and carbon oxides during combustion. Vapors can form explosive mixtures with air.
Protection for Firefighters: Use full protective gear including self-contained breathing apparatus. Keep containers cool with water spray from a safe distance.
Special Procedures: Move undamaged containers from fire area if safe. Dike runoff water to prevent environmental contamination.
Personal Precautions: Remove all non-response personnel. Wear chemical protection (respirator, gloves, goggles, suit). Evacuate area if necessary. No smoking, eliminate ignition sources.
Environmental Precautions: Prevent product from entering drains, watercourses, or soil. Inform authorities in case of significant spill.
Containment: Dam and absorb spillage with inert non-combustible material, such as sand or earth.
Cleanup Methods: Shovel absorbed material into a labeled, leak-proof container for disposal. Ventilate area after cleaning. Wash contaminated surface with water and detergent.
Safe Handling: Handle in well-ventilated areas. Ground containers and transfer equipment. Avoid splashing, breathing vapors, and contact with skin or eyes. No open flames, sparks, or hot surfaces. Use non-sparking tools.
Hygiene Practices: Wash hands and face after working. Remove contaminated clothing right away.
Storage Conditions: Store in cool, well-ventilated area away from incompatible substances. Keep container tightly closed in a dry place. Protect from light and heat.
Incompatible Materials: Strong oxidizers, alkali metals, nitric acid, strong bases.
Packaging Materials: Use material resistant to brominated hydrocarbons (glass, some plastics).
Control Parameters: No established workplace exposure limits in most jurisdictions. Monitoring of air levels advisable where used frequently or in large amounts.
Engineering Controls: Use chemical fume hood with forced ventilation. Emergency eyewash and safety shower in work area.
Personal Protection:
- Respiratory Protection: Approved respirators (organic vapor cartridge or air-supplied) if vapor levels exceed limits.
- Hand Protection: Nitrile, neoprene, or PVA gloves recommended.
- Eye Protection: Tightly fitting chemical safety goggles. Face shield for large volumes.
- Skin and Body: Lab coat or apron, impervious protective clothing for bulk handling.
Environmental Controls: Do not discharge into drains or surface waters. Use leak-proof storage and plumbing. Regular checks for leaks.
Appearance: Colorless liquid
Odor: Sweet, ether-like
Odor Threshold: No data available
pH: Not applicable (non-aqueous)
Melting Point/Freezing Point: -122°C
Boiling Point: 71-72°C
Flash Point: -8°C (closed cup)
Evaporation Rate: No data available
Flammability: Highly flammable liquid and vapor
Upper/Lower Flammability Limits: 8.5% (upper), 1.7% (lower; estimated)
Vapor Pressure: 260 mmHg at 20°C
Vapor Density: 4.6 (air = 1)
Relative Density: 1.23 at 20°C
Solubility: Practically insoluble in water; miscible with most organic solvents
Auto-Ignition Temperature: 460°C
Decomposition Temperature: Data not available
Partition Coefficient (n-octanol/water): Log Kow approx. 2.7
Viscosity: Data not available
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reacts with strong oxidizers, strong bases, alkali metals, nitric acid
Hazardous Reactions: May form explosive mixtures with air. Reaction with water, strong bases, or nucleophiles produces tert-butyl alcohol and hydrogen bromide
Conditions to Avoid: Heat, flames, sparks, static discharge, sunlight
Hazardous Decomposition Products: Hydrogen bromide, carbon monoxide, carbon dioxide, bromine gases
Polymerization: Does not polymerize under normal conditions
Likely Exposure Routes: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Oral LD50 (rat): estimated 1090 mg/kg. Inhalation LC50 (rat, 4h): estimated 15 mg/L. Dermal LD50: data not available
Skin Corrosion/Irritation: Causes irritation; repeated contact may cause dermatitis
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory Effects: Vapors can cause drowsiness, dizziness, and irritation
Cancer, Mutagenicity, Reproductive Toxicity: No confirmed evidence, but use with caution due to lack of long-term data
STOT—Single Exposure: Drowsiness or dizziness possible
STOT—Repeated Exposure: Data not sufficient for full assessment
Symptoms of Overexposure: Irritation of eyes, nose, throat, skin; headache, nausea, vomiting, dizziness
Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term effects in the aquatic environment
Persistence and Degradability: Not readily biodegradable; persistent in the environment
Bioaccumulation Potential: Moderate (Log Kow ~2.7)
Mobility in Soil: Low water solubility; may persist in soil, especially under anaerobic conditions
Other Adverse Effects: Brominated hydrocarbons may be toxic to aquatic species even at low concentrations. Do not allow material to contaminate groundwater or the wider environment.
Waste Treatment Methods: Dispose through licensed chemical waste contractor in accordance with local, national, and regional regulations. Incineration in a chemical incinerator with afterburner and scrubber preferred method.
Contaminated Packaging: Rinse with water or appropriate solvent before disposal. Dispose of rinsate as hazardous waste. Do not re-use container without proper decontamination.
Other Disposal Recommendations: Do not pour into drains, water courses, or onto the ground. Seek guidance from environmental authorities for proper methods in your jurisdiction.
UN Number: UN 1129
Proper Shipping Name: tert-Butyl bromide
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: II
Labels Required: Flammable liquid (3)
Special Precautions: Keep away from heat and sources of ignition. Handle carefully during transport to prevent container breakage or leakage.
Environmental Hazards: Marine pollutant. Report accidental releases to appropriate agencies.
Transport Regulations: Complies with ADR/RID, IMDG, IATA/ICAO rules for hazardous chemicals.
Classification and Labeling: Follows GHS, OSHA Hazard Communication Standard, European CLP Regulation (EC) No 1272/2008
Inventory Listings: Listed in TSCA, EINECS/ELINCS, DSL/NDSL inventories
US Regulations: SARA 313 listed (toxic chemical). CERCLA RQ: Not determined
EU Regulations: Subject to REACH registration and restriction (Annex XVII for certain uses)
Restrictions: Use and disposal strictly regulated in several countries due to acute toxicity and environmental impact
Other Information: Observe all chemical safety directives and workplace exposure advisories. Employers must supply adequate instruction and training for safe handling and use.
