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Product Name: 2-Amino-1,3,4-Thiadiazole
Chemical Formula: C2H3N3S
Synonyms: Aminothiadiazole, Amino-1,3,4-thiadiazole
CAS Number: 496-58-0
Recommended Use: Laboratory reagent, pharmaceutical intermediate, chemical synthesis
Supplier: Check with specific supplier for industrial or academic procurement
Contact Information: Refer to local distributor or company safety manager for handling questions
GHS Classification: Acute toxicity (Oral), Skin irritation, Eye irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust. Wear protective gloves and eye protection. Wash hands after handling. Keep container tightly closed.
Chemical Name: 2-Amino-1,3,4-Thiadiazole
CAS Number: 496-58-0
EC Number: 207-822-0
Concentration: Greater than 98%
Impurities: Trace amounts of related thiadiazoles and byproducts below 2%
Inhalation: Move to fresh air without delay. Seek medical attention if symptoms develop such as headache, dizziness, or respiratory discomfort. Provide oxygen if breathing is difficult.
Skin Contact: Remove contaminated clothing right away. Wash skin with copious amounts of water and non-abrasive soap. Get medical advice if rash or burns appear.
Eye Contact: Rinse eyes cautiously with water for 15 minutes keeping eyelids open. Remove contact lenses if present and possible. Seek evaluation by a medical professional.
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting. Give small sips of water if person is conscious. Obtain medical attention promptly.
General Advice: Provide the product label or MSDS to emergency personnel.
Suitable Extinguishing Media: Use dry chemical, foam, or carbon dioxide for small fires. Water spray can be used for larger fires but avoid using a direct water jet.
Hazards During Fire: Decomposition releases toxic fumes, including nitrogen oxides, sulfur oxides, and ammonia vapors. Combustion may produce noxious gases.
Protective Equipment: Wear full protective clothing including NIOSH-approved self-contained breathing apparatus.
Special Procedures: Cool exposed containers with water spray. Prevent fire-fighting runoff from entering drains and waterways.
Personal Precautions: Put on chemical-resistant gloves, lab coat, and protective eyewear. Avoid breathing in dust or vapors during cleanup.
Environmental Precautions: Prevent spills from seeping into soil, drains, or water bodies. Notify authorities if a significant spill causes environmental contamination.
Clean-Up Methods: Scoop or sweep material into recovery or disposal container. Minimize dust formation. Wash area with copious amounts of water and detergent after removal. Ventilate area before reuse.
Handling: Keep containers sealed when not in use. Work only in well-ventilated areas or with local exhaust ventilation. Avoid contact with skin, eyes, and clothing. Do not ingest, inhalation is also hazardous.
Storage: Store in a cool, dry, and well-ventilated place, away from heat sources and incompatible chemicals like oxidizing agents and acids. Keep container tightly closed in a secure area. Avoid exposure to direct sunlight and humidity. Use secondary containment if available.
Occupational Exposure Limits: No OSHA or ACGIH limits established; minimize exposure through engineering controls.
Engineering Controls: Local exhaust ventilation or fume hood required.
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), safety goggles or face shield, lab coat or apron.
Respiratory Protection: Use an approved particulate respirator if handling large quantities or in poorly ventilated areas.
Hygienic Measures: Wash hands after handling, remove contaminated clothing, do not eat or drink near product.
Appearance: Light yellow to light brown crystalline powder
Odor: Odorless or very faint aromatic scent
Melting Point: 202–205°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable (decomposes)
Solubility: Slightly soluble in water, soluble in ethanol and acetone
Vapor Pressure: Negligible
Specific Gravity: 1.55–1.60 g/cm³
pH (1% solution): Slightly acidic
Other: Stable under recommended conditions, may darken on exposure to air or light
Chemical Stability: Stable under standard storage conditions
Hazardous Reactions: Reacts with strong oxidizers, strong acids, and bases. Contact with potent oxidants may cause ignition or violent reaction.
Decomposition Products: Gives off toxic sulfur oxides, nitrogen oxides, and ammonia vapor when decomposed by heat or combustion.
Other Reactivity: May form dust-air mixtures capable of explosion in finely divided form if exposed to ignition sources.
Acute Toxicity: Oral LD50 (rat): approx. 300–500 mg/kg. Inhalation and dermal exposure may cause local irritation.
Skin Contact: Can cause redness, itching, and dermatitis after prolonged or repeated exposure.
Eye Contact: May result in severe irritation, redness, tearing, and blurred vision.
Chronic Effects: No long-term data in humans; repeated high-level exposure can produce cumulative effects in laboratory animals.
Carcinogenicity: Not classed as carcinogenic by IARC, NTP, or OSHA based on available data.
Other: No evidence of reproductive toxicity or mutagenicity in standard tests.
Aquatic Toxicity: Harmful to aquatic organisms based on predicted properties. LC50 in daphnia (estimated): 10–100 mg/L.
Persistence and Degradability: Not readily biodegradable; may persist in soil or water.
Bioaccumulation: Low potential for bioaccumulation.
Mobility in Soil: Moderate; may leach if released in large quantities.
Other Adverse Effects: Large spills may disrupt local ecosystems. Prevent discharge into waterways.
Waste Treatment Methods: Dispose of product as hazardous chemical waste, in accordance with local, regional, national, and international regulations. Do not incinerate in open air.
Contaminated Packaging: Triple rinse containers. Dispose of empty drums, bottles, or liners as hazardous waste.
Special Precautions: Avoid release to sewers or environment. Consult local environmental authority for guidelines on safe disposal or neutralization.
UN Number: Not classified for transport under United Nations’ model regulations.
Proper Shipping Name: 2-Amino-1,3,4-thiadiazole
Transport Hazard Class: Not regulated for road, rail, sea, or air. Consider as hazardous chemical in bulk shipment.
Packing Group: Not assigned.
Environmental Hazards: Not a marine pollutant.
Special Precautions: Secure packaging to prevent spillage during transit. Confirm that recipients are aware of handling and safety guidance.
TSCA Status: Listed on the US Toxic Substances Control Act Inventory.
REACH Status: Registered or pre-registered in the European Union for REACH purposes.
DSL/NDSL (Canada): Listed.
WHMIS Classification: D2B (Toxic material causing other toxic effects).
OSHA: Hazardous chemical under 29 CFR 1910.1200.
Other Local Regulations: Comply with additional national, state, or local chemical safety regulations. Ensure employee awareness and safety documentation training.
