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Name: 2,6-Lutidine
Chemical Formula: C7H9N
CAS Number: 108-48-5
Common Uses: Laboratory solvent and intermediate for pharmaceuticals, agrochemicals. This chemical commonly finds its way into research spaces and manufacturing plants, not only for its solvent abilities but also for fine chemicals development.
GHS Classification: Flammable liquid (Category 3), Acute toxicity–oral (Category 4), Eye irritation (Category 2A), Skin irritation (Category 2)
Signal Word: Warning
Hazard Statements: Flammable liquid and vapor. Harmful if swallowed. Causes skin and eye irritation. Long-term or repeated workplace contact can dry out skin or worsen eczema. This substance can burn readily and releases toxic fumes on combustion, making open flame, sparks, or bad storage practices a recipe for trouble.
Main Ingredient: 2,6-Lutidine, ≥98% purity in standard research settings
Impurities: Methylpyridines are possible contaminants in technical grades, but most commercial samples aim for high purity to reduce unpredictable reactions.
Eye Contact: Rinse eyes cautiously with water for several minutes. Remove lenses if present and easy. Eye exposure can sting, blur vision, and needs prompt rinsing.
Skin Contact: Wash skin with soap and water. Clothing stuck to the skin should come off to avoid more irritation.
Inhalation: Move to fresh air. Breathing in may irritate nose, throat, lungs, and bring on coughing or shortness of breath. Seek medical help if symptoms stick around.
Ingestion: Rinse mouth. Unless experts guide otherwise, avoid throwing up. Poison control can help prevent more harm in cases of larger ingestions.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam. Water spray works, but large streams may spread burning liquid.
Special Hazards: Burning this compound gives off nitrogen oxides and carbon monoxide.
Advice for Firefighters: Protective gear and self-contained breathing apparatus matter. Stay upwind. Keep runoff out of water systems when dealing with a larger fire.
Personal Precautions: Wear gloves, goggles, and avoid skin exposure. Scrubbing down the area with good ventilation is key. Vapors can collect, so test air quality in tight places.
Methods for Clean Up: Soak up with sand, vermiculite, or clay—never use sawdust. Seal everything for disposal by professionals. Dilute residue with soapy water; always air out the affected area fully.
Handling: Keep away from open flames and avoid making static. Use in well-ventilated zones. Don’t eat, drink, or smoke during use. Replace container caps tightly right after use.
Storage: Store in tightly closed containers in a cool, dry space. Keep containers out of sunlight and away from incompatible substances. Segregation from acids and strong oxidizers prevents dangerous reactions if leaks happen.
Engineering Controls: Work under a chemical hood whenever possible to reduce vapor exposure. Rooms with exhaust fans or strong cross-ventilation protect everyone.
Personal Protective Equipment: Wear nitrile gloves, safety goggles, and lab coat. Where splashes or vapor exposure may pop up, respirators fitted with organic vapor cartridges go a long way.
Exposure Limits: No specific OSHA PEL, but always treat any strong-smelling vapor in the lab with respect. Monitor breathing air for unusual spikes if working with bigger quantities.
Appearance: Colorless to pale yellow liquid
Odor: Characteristic sweet, pungent, even fishy at high enough levels
Boiling Point: About 144°C
Melting Point: -6°C
Vapor Pressure: Around 5 mmHg at 25°C
Solubility: Moderately soluble in water, mixes with most organic solvents
Flash Point: 36°C (closed cup), making it catch at a warm room temperature
Density: Approximately 0.93 g/cm³
Labs often have sniffed it out because the odor can hang around equipment, even at low concentrations.
Chemical Stability: Resists slow breakdown in tight, cool, dry conditions with low humidity.
Reactivity: Will react with strong oxidizing agents and acids, which can lead to fire or hazardous gas release. Keeping it away from heat, sparks, and sources of ignition helps avoid surprise exothermic events.
Routes of Exposure: Eyes, skin, inhalation, swallowing
Symptoms: Burning, redness, headache, drowsiness, nausea from inhalation or ingestion. Skin or eye exposure irritates quickly.
Acutely Toxic: Animal studies show oral doses as low as 400 mg/kg can cause effects in rats. Long-term exposure irritates skin and may worsen pre-existing dermal or respiratory conditions.
Environmental Impact: Moderately toxic to aquatic life, especially fish and plankton at higher concentrations. Product can spread in water and linger for days, so lab wastewater needs extra filtration. Runoff into streams or ponds means risk for frogs, insects, and fish in the local ecosystem. It doesn’t quickly break down in soil, which means caution for regular users.
Disposal Methods: Hand off waste materials and clean-up residues to a certified disposal contractor. Avoid dumping into sinks, trash bins, or outdoor drains. Local and federal regulations require documentation to prevent environmental harm, especially with larger quantities.
UN Number: UN 2653
Transport Hazard Class: Flammable Liquid (Class 3)
Packing Group: III
Shipping containers should stay upright, tightly shut, with hazard labels clearly attached. Ground transport, sea freight, and air shipments all require paperwork and hazard declarations to avoid regulatory fines and ensure readiness in case of spills.
Regulations: Listed on TSCA Inventory. Subject to workplace safety standards in the US, Canada, Europe, and Asia. Storage, handling, and disposal require attention to local authority mandates to protect people and waterways. Safety committees in universities and industry update protocols based on these standards to stay compliant and reduce workplace health incidents.
