Chemistry lives and breathes through its odd corners, and the study of dioxanes offers a good example of both chemical intrigue and practical concern. Looking across the last century, 2,5-Dimethyl-1,4-dioxane emerged as a small, often-overlooked molecule, tucked away in the annals of ether chemistry. As labs pushed to design solvents and intermediates that fit specific niches, tinkering with classic dioxane created compounds like this one. Research into glycol-derived cyclic ethers ramped up with advances in organic synthesis, and as chemical literature piled up, this dioxane derivative earned modest attention for its structural quirks. Publications tracking cyclic ethers or searching for non-traditional solvents gave it a brief moment in the sun, yet widespread adoption never really crystallized, probably because other solvents—many less cumbersome and less risky—stayed easier to obtain and handle. Chemists, including myself, often found themselves browsing old literature or standard texts, noticing 2,5-Dimethyl-1,4-dioxane among lists but rarely pulling it off the shelf for everyday projects.
2,5-Dimethyl-1,4-dioxane sits in that awkward spot: not a workhorse, not rare enough to command high curiosity prices either. This clear, colorless liquid owes its existence to straightforward synthetic routes, typically derived from glycol intermediates. As with most derivatives in its family, the focus lands on function, not flair. Industrial use drops off fast—the molecule lacks the broad appeal or safety record of staples like tetrahydrofuran or classic 1,4-dioxane. For anyone working in laboratory settings, the chemical occasionally surfaces as a niche solvent, sometimes playing a bit part in reaction optimization or in complex mixture separations. Most inventories mention it as a specialty solvent or as a possible intermediate in syntheses requiring highly selective ether functionality. That obscurity doesn’t make it less interesting, only less universal.
Chemists appreciate a solvent that behaves. 2,5-Dimethyl-1,4-dioxane falls into a predictable pattern shaped by ether chemistry: low viscosity, noticeable hydrophobicity, and a boiling point that hovers near the upper range for small ethers. It resists water, mixes well with other organics, and maintains chemical stability under unremarkable conditions. Like other dioxanes, the membered ring stays relatively rigid, resisting acid or base hydrolysis in dilute settings. Anyone who has spilled it in the lab remembers the sweet, ether-like odor, a signal of low molecular weight and volatility that matches other ethers. That volatility demands careful storage and attention to fire risks. It doesn’t corrode glassware or attack most elastomers, but its solvent power for organic materials forces technicians to watch for unintended extraction. Specifics on physical constants usually parallel those of close cousins—minor density variation, similar refractive index, and comparable solubility profile.
Any bottle of 2,5-Dimethyl-1,4-dioxane carries the language chemists now expect: hazard warnings, flammability symbols, and clear CAS identification. Laboratory supply companies ship it in amber glass under tight caps due to its tendency to pick up water and oxygen. It deserves a place on the same chemical shelf as other ethers—secure, dry, and well away from sources of ignition or oxidants. Clear labeling on purity and possible stabilizers stays critical. In my experience, chemicals like this rarely move fast, so storage sometimes stretches past their recommended lifetime. Awareness of peroxide formation, a bugbear for all low molecular weight ethers, needs to stay high. Shelf checks and test strips never struck me as fun, yet the cost of ignoring them runs much higher. Batches should get tested if they’ve sat for more than a few months; explosions from peroxide contamination remain a very real danger for inattentive hands.
Lab work with 2,5-Dimethyl-1,4-dioxane starts from accessible starting materials, usually drawing from glycol-based synthons. Standard synthetic routes involve acid-catalyzed cyclization, often starting with 2,5-dimethyl-1,4-butanediol. This process requires careful balancing—over- or under-catalyzed reactions spit out a tangle of byproducts or leave starting material unreacted. Years of speed and convenience pushed many synthetic labs to offload this work to dedicated suppliers rather than running rings around inefficiency. Still, the core reaction—dehydration, ring closure, distillation—hasn’t changed much, and scale-up to industrial volumes involves tweaking catalyst loading, purification steps, and safety controls. Old patents read like recipes: modest heat, controlled addition, plenty of water separation. I’ve watched glassware cloud up with nascent dioxane, the distillation head gleaming with fresh solvent. Scale brings its own headaches, though, and keeping impurities out requires skill and patience, especially since regulatory pressures now treat most dioxane derivatives with increasing skepticism.
Tinkering with 2,5-Dimethyl-1,4-dioxane won’t please someone hunting for drama; the compound’s backbone stays stable in routine organic chemistry. Strong acids or bases can tear the ring open, generating aldehydes or even carboxylic acids if pushed hard enough. Most substitution reactions need a heavy hand—halogenation, sulfonation, or oxidation call for robust conditions. Minor side reactions show up in the literature, but the molecule’s symmetry and electron-rich core generally block easy access for many organic transformations. Safety matters: attempted modifications that ignore ring stability sometimes generate explosive or toxic byproducts, a lesson some researchers have learned the bruising way. Routine use focuses on blending the compound or using it as a relatively inert reaction medium, especially when high purity and low water content matter.
Names in chemical labeling matter, because confusion invites disaster. In catalogues, 2,5-Dimethyl-1,4-dioxane sometimes pops up under alternate headings, from “dimethyldioxane” to more specific structural inferences. That sort of lexical muddle matters less in professional circles—CAS registry numbers cut through ambiguity. As a lab worker and occasional teacher, I’ve insisted on cross-referencing by structure and identifying number, since even small label mistakes can cause big headaches down the line. In journal articles, synonyms fade as molecular identification tightens, but industrial catalogues sometimes hang onto regional or legacy names, enough to keep confusion alive.
Every chemical bottle tells its own story in the operating manual, and with ethers, the headline reads “flammability.” 2,5-Dimethyl-1,4-dioxane burns quickly, and its vapors spread in ways that defy casual containment. Personal experience says: never underestimate the unpredictability of small ethers around open flames or heat sources. Proper ventilation and spark-proof equipment deserve serious respect. Storage under inert gas isn’t always strictly necessary, but in humidity-prone climates, it helps extend shelf life by slowing both water uptake and peroxide formation. Peroxides scare most chemists more than fire—too many case studies chronicle unplanned detonations. Regular peroxide screening and use of stabilizers can cut the danger, but no system is foolproof. Chemical hygiene plans keep this compound firmly in the “handle with care” category. Protective gloves, eye shields, and chemical splash aprons aren’t optional.
The use-cases for 2,5-Dimethyl-1,4-dioxane aren’t splashy or high-profile—demand comes mainly from specialty synthesis, tricky separation work, or as an occasional component in formulated products. Small-scale solvents like this one sometimes find a role in pharmaceutical research, where the unique blend of polarity and volatility solves select solubility puzzles. Chemical research labs use it when a combination of low water content and stability can’t be matched by more common ethers. In analytical chemistry, the solvent’s clean background and ability to dissolve stubborn organic residues make it a tool worth reaching for, if only occasionally. Industrial uses remain pretty limited; costs, safety, and regulatory questions keep it out of most mainstream applications. In specialty polymer or fine chemical synthesis, it might play a small role, but it doesn’t anchor any major manufacturing process that I know.
The chemistry of dioxane derivatives remains a routine topic in academic research, mostly as an outgrowth of interest in ring systems, solvent safety, or synthetic methodology. 2,5-Dimethyl-1,4-dioxane sometimes serves as a model system—its structure lets researchers predict reactivity or compare trends in ether chemistry. Funding and publication incentives haven’t spurred major innovation here; journals and grant organizations tend to favor high-impact molecules over niche solvents. Nevertheless, each year brings a trickle of new papers examining how such molecules behave as solvents, reagents, or as test cases for catalytic transformations. Scientists keeping an eye on lab safety protocols watch for new research on peroxide inhibition or alternative degradation pathways. Computational chemists occasionally analyze its conformational dynamics, offering small insights for those building better predictive models. But in the competitive world of chemical innovation, dioxane derivatives today play mostly for supporting roles.
Ethers once floated under the regulatory radar, with their sweet smell and general ease-of-handling lulling people into poor safety habits. As more data poured in, toxicologists began re-evaluating the risks associated with dioxanes. Structural kinship to 1,4-dioxane—the infamous listing among probable human carcinogens—casts a shadow over 2,5-Dimethyl-1,4-dioxane. Animal testing and cell studies have underlined the dangers: chronic exposure brings organ damage, with the liver and kidneys especially vulnerable. Inhalation loads up risk for both acute and chronic toxic effects. Metabolic pathways, though not fully charted, echo the fate of related ethers—oxidative cleavage, formation of reactive aldehydes, and bioaccumulation in fatty tissues. Regulatory agencies look hard at molecules that straddle the fine line between safety and hazard, and few chemists argue against minimization of unnecessary exposure. In my own experience, switching to less dangerous alternatives where possible never feels wasteful—nobody wants to trade speed or convenience for lifelong health effects.
Interest in 2,5-Dimethyl-1,4-dioxane’s applications isn’t likely to surge unless a broader shift in solvent technology arises. Pushes for greener chemistry and lower toxicity continue to shape product selection, and regulatory scrutiny remains intense. Industry now favors solvents with clear safety profiles, lower toxicity, and straightforward environmental fate. There remains a slim chance for niche growth, especially if unique physical properties solve problems standard ethers cannot. Innovations in solvent recycling, process intensification, or specialty polymer synthesis could shine a brief spotlight on compounds like this. For the most part, though, research will likely pivot toward safer, more sustainable alternatives. Training and discipline remain the best tools for people who still have to work with compounds in this category. If commercial need spikes, industry will probably look for ways to retrofit safety protocols or develop in situ generation to minimize handling risks. Otherwise, the compound will continue as a specialty product: useful for a specific problem, respected by those who know its properties, and ever in need of careful handling.
Ask someone outside of a chemistry lab about 2,5-Dimethyl-1,4-Dioxane, and you’ll probably get a blank stare. The name alone sounds like a tongue twister. In industrial circles, this compound finds its way into several processes. Its real story tends to fly under the radar unless you’ve had reason to work with solvents or surfactants. Years back, working in a plant that manufactured specialty cleaners, I handled a few dioxane derivatives. Practical experience beats textbook definitions here. The handling and use left plenty of lessons about their capabilities and risks.
2,5-Dimethyl-1,4-Dioxane gets picked up mainly for its solvent qualities. It dissolves substances that water cannot tackle, often improving efficiency in manufacturing. In practice, this means chemists tap it for breaking down complex mixtures or separating targeted compounds. The paint industry knows this routine well. If you pull data from the EPA’s databases, you spot traces of this compound in cleaning agents or even certain lubricant formulas. The reason? Its molecular structure brings the right balance between dissolving power and low reactivity with other chemicals involved in the mix.
For many years, factories relied on forms of dioxane and similar substances to boost efficiency. 2,5-Dimethyl-1,4-Dioxane doesn’t show up on household product labels but supports industrial processes quietly. Researchers at large manufacturers want stability and consistency, so they go to solvents with predictable behavior. This compound fits the bill. In a laboratory, its resilience against breaking down under normal conditions means fewer interruptions or unexpected breakdowns. Anyone who has had machinery grind to a halt knows the headache that comes from equipment failure. Stable solvents like this help avoid those hiccups.
Chemists trust dioxane derivatives for a reason, but the health side catches up quickly. The wider chemistry world knows the ill effects of some dioxanes, especially after warnings from regulatory bodies. 1,4-Dioxane itself triggered alarm bells due to carcinogenic risk. This sheds light on safety with 2,5-Dimethyl-1,4-Dioxane. Workers dealing with large quantities need strong safety routines. I remember double-checking ventilation and wearing gloves, even when the label didn’t scream danger. Better to err on the side of caution than deal with mysterious headaches at the end of a shift.
Industry doesn’t stand still. Over time, companies started exploring safer and greener alternatives. The push to swap out riskier solvents gets stronger each year, especially in places where environmental oversight has teeth. Engineers tackle this problem by searching for compounds that deliver the same benefits with a softer safety profile. Science journals now fill with case studies about new blends and routes to the same results, aiming to leave risky chemicals behind. Nobody working on the factory floor wants to trade their health for a cheaper cleaner.
2,5-Dimethyl-1,4-Dioxane offers real value to specialized manufacturing, but blind trust in a chemical has always proved risky. Recognizing its strengths gives industry an edge, but the need for ongoing review never goes away. Listening to researchers, plant workers, and regulators keeps everyone honest. Companies embracing evidence-based decisions see results, safer workplaces, and better products on the market.
2,5-Dimethyl-1,4-dioxane might pop up during work in organic synthesis or certain research projects. This isn’t just another bottle on the shelf – it has a reputation for both volatility and potential harm. Unlike common solvents, this compound can slip into the air and isn’t especially forgiving if spilled, splashed, or breathed in. Safety in handling isn’t just for show: skipping even small steps invites bigger trouble down the line.
Nobody feels comfortable fielding chemical burns or lung trouble, so covering up is standard practice. Full-length lab coats, tight-fitting safety goggles, and gloves rated for organic solvents become daily armor. Latex usually won’t hold up – nitrile or neoprene perform better. A splash on bare skin delivers more than a minor sting, and even the vapor can start itching eyes or nose almost at once.
Gloves only work until they’re breached. Once wet or compromised, swapping them out beats taking a chance. I’ve seen more than one chemist ignore a tiny hole, and that rash isn’t worth the gamble. Closed-toe shoes and keeping street clothes covered protect against spills reaching further.
Open air isn’t generous enough for 2,5-dimethyl-1,4-dioxane. Fume hoods aren’t a luxury here – they become the only safe way to work. This compound turns into vapor at room temperature, and inhaling it doesn’t stay in the lungs. It can quickly move to headaches, dizziness, or worse. Good ventilation draws away fumes that could otherwise hang around and get into the bloodstream.
From my own time near similar ethers, a fan or open window doesn’t cut it, and “just a quick transfer” can bring lasting side effects if done out in the open. The habit of keeping everything under the hood keeps accidents rare and airways clear. It’s never worth rushing.
Storing 2,5-dimethyl-1,4-dioxane isn’t about tucking the bottle anywhere there’s room. This chemical likes to form peroxides over time, which can turn a simple bottle into a hazard. Sealed, labeled containers, kept away from heat and direct sunlight, reduce risks. Anything stored for longer needs checking for crystals or cloudiness before use. Ignoring these signs has led more than one lab to a close call.
If a spill happens, evacuate anyone not dealing with the cleanup and grab the spill kit. Silica, vermiculite, or sand absorbs the mess. Never mop up with paper towels or old rags – those can make the mess worse. Careful containment, then safe disposal, ends the crisis. Fire extinguishers should suit chemical fires, specifically dry chemical or foam, since this compound feeds flames fast. Water alone spreads the mess.
It’s easy to overlook planning until alarms go off. Safety drills, up-to-date material safety data sheets, and knowing the path to the eyewash or shower help everyone react calmly. I’ve seen firsthand how panic drops once everyone knows their role – and how even seasoned researchers can freeze up without practice.
Real safety grows from habit. The right protective gear, attention to air quality, and strict storage aren’t up for debate. Mistakes with 2,5-dimethyl-1,4-dioxane stick with you. Training, peer reminders, and good inventory control go a long way. A strong culture around safety – not just a laminated sheet on the wall – keeps everyone healthy and research on track.
2,5-Dimethyl-1,4-dioxane shows up as a colorless organic compound used mostly by chemists and researchers, not a chemical that finds its way into most household products or the food supply. Folks in labs might work with this molecule when developing specialty materials or in research about organic synthesis. Most people have never heard of it, and that includes neighbors, friends, or relatives unless they spend their days working with complex chemical structures.
Some chemicals instantly raise red flags. Years ago, headlines about 1,4-dioxane made waves because of water contamination and potential cancer risks. The 2,5-dimethyl derivative carries a family resemblance, which means extra scrutiny always makes sense. The base structure of dioxanes, particularly how they behave when inhaled or ingested, often links to toxicity in animals. Scientists classify these compounds as “potentially hazardous” because of what happens at the cellular level—breaking down into smaller fragments that can trip up vital biological processes.
Looking at toxicity data for this dioxane cousin, gaps remain. Not enough studies have tested its exact impact in humans. Research often involves rodents or cell cultures, so scientists fill in the blanks using what they know about the main dioxane group. For example, both versions can irritate skin and eyes, create headaches, or affect breathing if someone gets exposed to high concentrations in a poorly ventilated place. That alone makes me treat any mystery chemical with caution, gloves, and strong opinions about good ventilation.
Anyone stepping into a lab—high school, university, industrial—remembers their training: If you can’t easily find toxicity data, always work with the chemical as if it could cause harm. I’ve watched beginners pick up a clear liquid, thinking “no color, no smell, must be harmless.” That’s the trap with dioxanes. They slip by our senses and do their work behind the scenes. Even the mildest symptoms like skin dryness or a scratchy throat become a warning if you listen closely.
Fact: Some dioxanes, including the parent compound, linger in water and resist the usual cleanup methods. The EPA listed 1,4-dioxane as a probable human carcinogen, and this related molecule shares enough in structure that regulators keep a close watch. In my own academic days, we never used such chemicals outside a fume hood. Anyone ignoring that advice often learned fast once headaches or coughing began halfway through an experiment.
The biggest problem comes down to knowledge gaps. Busy researchers and manufacturers sometimes handle compounds with patchy safety profiles. Strong regulation, open databases, and rigorous labeling protect workers. The best fix involves demanding up-to-date, easy-to-read safety information for every chemical in the workplace—not just the high-profile ones.
Public water utilities and waste treatment plants use advanced filtration when worried about dioxane-type molecules. More research and transparency help neighbors, families, and anyone near an industrial area know what really gets into the water and air. Until the full story on 2,5-dimethyl-1,4-dioxane’s hazards shows up, treating it with a healthy respect and strict safety protocols works better than trusting wishful thinking.
EPA’s chemical fact sheets and peer-reviewed studies give background on dioxane toxicity. The National Institute for Occupational Safety and Health (NIOSH) offers workplace exposure guidelines. Scientists update those pages as new health data arrive. People at home should push local officials for test results whenever they hear about chemical incidents involving dioxane-type compounds.
Chemistry doesn’t have to feel like a locked door. 2,5-Dimethyl-1,4-Dioxane’s name tells you a lot about its structure if you break it down. The backbone comes from dioxane, a six-membered ring containing two oxygen atoms. These sit across from each other, making the molecule a cousin of well-known ethers, but with a twist: the ring shape brings a predictable stability. Now, those numbers—2,5-dimethyl—mean each of those spots carries a methyl group, basically a -CH3 hanging off the ring.
The chemical formula lines up as C6H12O2. To see the skeleton, picture a hexagon, with the oxygen atoms taking their place at opposite corners. Methyl groups branch off the carbons next to each oxygen. It sounds complicated in a textbook, but in an organic lab, this kind of molecule feels routine: you watch ring structures all the time, and the way those methyls change boiling point and solubility can really shift how you handle a chemical.
Having spent time in labs, a compound like this never draws crowds for its excitement, but give it to an organic chemist setting up a reaction, and you see appreciation. Ring ethers like 2,5-dimethyl-1,4-dioxane have that clean, almost symmetrical shape that influences their behavior. The methyls don’t just make the name longer, they tweak how the molecule dissolves and reacts, sometimes improving stability compared to the parent dioxane.
These methyl groups add bulk, which helps cut down on the formation of peroxides. Peroxides like to form in plain dioxane; they’re hazardous and unpredictable. Over years, stories circulate about old bottles quietly forming peroxides on forgotten shelves—so methyl groups here deliver more than just a cosmetic upgrade. Stronger structure means safer storage and less stress for anyone working with organic solvents.
The widespread appeal of six-membered ring ethers in chemical synthesis makes sense: their resilience to acids and bases often helps reactions along. Take the standard dioxane, strip two hydrogens and pop two extra methyl groups in place—now, with 2,5-dimethyl-1,4-dioxane, you often get lower water solubility, a higher boiling point, and more resistance to those pesky peroxides.
In real-world settings, safety always takes the front seat. Methyl substituents lessen the risks for long-term storage, and even simple changes in structure—especially in cyclic ethers—bring practical benefits in handling. Lab techs and chemists don’t just nod along to the theoretical. Changes like these shape the day-to-day landscape, from planning experiments to managing chemical inventories.
Chemical structure doesn’t just live on paper. Every functional group carved onto a molecule tips a domino, and for dioxane rings that see heavy use in synthesis, steps to reduce hazards really matter. The reduced peroxide risk in 2,5-dimethyl-1,4-dioxane stands out as a smart move, especially for labs thinking about longevity of stock and protecting their teams. Regulatory interests follow, too—knowing a compound’s structure helps set safe work practices and storage rules.
Changes on a molecular level echo through to health, safety, and shelf life. Researchers can build on this foundation to develop even safer and cleaner solvents, raising the bar for chemical handling and experimentation across the board.
2,5-Dimethyl-1,4-dioxane isn't a common name in the average household, but folks in labs and factories understand the risks all too well. This chemical has a reputation for staying stable under most conditions, but one slip and trouble follows fast. A clear liquid, flammable, and carrying health risks, mishandling isn't an option. People can't ignore these dangers, especially after looking at stories from facilities that cut corners and sparked nasty incidents: fires, vapor inhalation, long cleanup routines.
Keep this compound under lock and key, away from sunlight, heat, and sparks. Metal safety cabinets do the job right because they offer fire resistance. Polyethylene shelves turn brittle, so metal doesn't just last; it shields better. Used glass or plastic containers with tight lids make sure nothing seeps out. All containers need clear hazard labels – no magic marker abbreviations – because nobody wants confusion if something goes wrong.
Overcrowded storage rooms tend to get overlooked, but tight spaces add risk. Chemicals squeeze together, and one leaky jug means fumes spread. A storage room needs working ventilation, good lighting, and regular checks. Anyone handling 2,5-Dimethyl-1,4-dioxane wears gloves and goggles, not because it's overcautious, but because years of records show how splash accidents pile up. Spill kits with absorbing pads, neutralizers, and reliable waste bins stay within easy reach. Sometimes a misplaced mop bucket takes up spill kit space, but this isn't a mop-water kind of mess.
Flushing chemicals down the drain never ends well. Authorities drop fines, water supplies get contaminated, and neighbors get angry. Real disposal means arranging chemical waste pickups with professionals certified in hazardous material handling. Sites that dispose correctly keep proof for every shipment. Regulators ask for paperwork; nobody wants to scramble for lost logs.
On-site, storage for hazardous waste has tight rules. Closed containers, set off from regular trash, with waste logs that detail amounts, pickup dates, and point of origin—those details count. Incineration at approved facilities often finishes the process because that’s how toxins break down without hitting air, soil, or water. Incinerators run at high temps—far above what any ordinary on-site oven could handle.
Ignoring protocols means employees face burns, nerve problems, headaches, or worse. Long-term exposure has consequences, even if the risk feels low from just a quick whiff. Think about the chemical fire in Illinois back in 2019—authorities traced mismanaged storage and weak disposal practices. Cleanup teams struggled for weeks; the fallout ran for miles.
Training new staff takes time, but cutting corners results in far more lost hours fixing preventable mistakes. Companies that run regular safety drills and update emergency plans fare better. Old storage containers, outdated goggles, or filled-to-the-brim waste bins should all trigger action. Leadership sets the tone: if managers ignore a leaky lid, workers follow suit.
Real change sticks when people see the direct connection between daily habits and big disasters. Proper storage and disposal require a culture of speaking up and calling out shortcuts before a problem grows. Regulators may hand out checklists, but nothing beats daily vigilance and a healthy respect for what these chemicals can do.
| Names | |
| Preferred IUPAC name | 2,5-Dimethyl-1,4-dioxane |
| Other names |
2,5-Dimethylparadioxane p-Dimethyldioxane |
| Pronunciation | /tuː,faɪv-daɪˈmɛθ.ɪl-wʌn,foʊ-daɪˈɒk.seɪn/ |
| Identifiers | |
| CAS Number | 696-23-1 |
| Beilstein Reference | 1080630 |
| ChEBI | CHEBI:140569 |
| ChEMBL | CHEMBL134333 |
| ChemSpider | 21519 |
| DrugBank | DB14096 |
| ECHA InfoCard | 03c10f4b-cf2f-4d73-9400-5483aaa9f3f8 |
| EC Number | 216-081-7 |
| Gmelin Reference | 82556 |
| KEGG | C18735 |
| MeSH | D017082 |
| PubChem CID | 11559 |
| RTECS number | JG8225000 |
| UNII | 95R9V3F8K9 |
| UN number | UN1165 |
| Properties | |
| Chemical formula | C6H12O2 |
| Molar mass | 118.17 g/mol |
| Appearance | Colorless liquid |
| Odor | Faint ethereal |
| Density | 0.921 g/mL at 25 °C |
| Solubility in water | Insoluble |
| log P | 0.49 |
| Vapor pressure | 1.7 mmHg (25 °C) |
| Acidity (pKa) | pKa ≈ 35 |
| Basicity (pKb) | pKb = 5.14 |
| Magnetic susceptibility (χ) | -82.4·10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.412 |
| Viscosity | 1.49 mPa·s (25 °C) |
| Dipole moment | 1.30 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 297.1 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -368.6 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -3581.7 kJ/mol |
| Hazards | |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS02, GHS07 |
| Signal word | Warning |
| Hazard statements | H226, H319 |
| Precautionary statements | P210, P273, P280, P370+P378, P403+P235, P501 |
| NFPA 704 (fire diamond) | 1-2-0 |
| Flash point | 77 °C |
| Autoignition temperature | 205 °C |
| Explosive limits | Explosive limits: 1.1–7.8% |
| Lethal dose or concentration | LD50 (oral, rat): 5180 mg/kg |
| LD50 (median dose) | LD50 (median dose): 5170 mg/kg (rat, oral) |
| NIOSH | Not established |
| PEL (Permissible) | Not established |
| REL (Recommended) | REL: NIOSH considers 2,5-dimethyl-1,4-dioxane to have no REL established |
| Related compounds | |
| Related compounds |
1,4-Dioxane 2-Methyl-1,4-dioxane 2,3-Dimethyl-1,4-dioxane 2,6-Dimethyl-1,4-dioxane 2,5-Dimethyltetrahydrofuran |