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Product Name: 2,3,5-Trichloropyridine
Chemical Formula: C5H2Cl3N
Chemical Family: Chlorinated pyridines
CAS Number: 2455-34-3
Synonyms: 2,3,5-Trichloro-1-azabenzene
Relevant Uses: Intermediate for synthesis of pharmaceuticals, agrochemicals, dyes
Manufacturer Information: Contact details provided on container label
Emergency Phone Number: Provided by manufacturer or CHEMTREC
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation) Category 4, Skin Irritation Category 2, Eye Irritation Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed, in contact with skin, or inhaled. Causes skin and serious eye irritation. May form explosive mixtures with air.
Precautionary Statements: Avoid breathing dust, fumes, or vapors. Use protective equipment. Wash hands thoroughly after handling. Do not eat, drink, or smoke near chemical.
Hazard Symbol: Exclamation mark
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms of Exposure: Burning sensation, redness, irritation to eyes and skin, respiratory discomfort, gastrointestinal distress
Chemical Name: 2,3,5-Trichloropyridine
Pyridine, 2,3,5-trichloro- CAS: 2455-34-3, Percentage: ≥98%
Impurities: Trace moisture, related chlorinated pyridines, ≤2% other organic compounds
Other Ingredients: None of significance
Inhalation: Move person to fresh air. Support breathing with artificial respiration if needed. Seek medical attention. Remove source of exposure.
Ingestion: Rinse mouth with water if conscious. Do not induce vomiting. Contact a physician or poison control immediately.
Skin Contact: Wash with soap and large amounts of water for at least 15 minutes. Remove contaminated clothing. Consult a physician.
Eye Contact: Rinse cautiously with water for several minutes, keeping eyelids open. Remove contact lenses if present and easy to do. Continue rinsing. Get medical advice if irritation persists.
Important Symptoms: Burning, redness, swelling, coughing, difficulty in breathing, abdominal pain, nausea.
Medical Notes: Treat symptomatically. Immediate medical care recommended for severe exposures.
Suitable Extinguishing Media: Use water spray, carbon dioxide, foam, or dry chemical.
Unsuitable Extinguishing Media: Do not use direct water jet as it may spread fire.
Hazards From Combustion: Releases toxic vapors including hydrogen chloride, nitrogen oxides, and phosgene under fire conditions.
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective clothing.
Special Procedures: Cool unaffected containers with water spray. Approach upwind to avoid hazardous decomposition gases.
Explosion Risk: Container may rupture if heated; vapors can form explosive mixtures with air.
Personal Precautions: Evacuate unnecessary personnel. Provide adequate ventilation. Wear protective clothing, gloves, safety goggles, and a respirator.
Environmental Precautions: Prevent spillage from reaching drains, surface water, or soil. Inform authorities if the product contaminates water systems.
Clean-Up Methods: Absorb spills with inert material like sand, earth, or vermiculite. Shovel into suitable chemical waste containers for disposal. Use non-sparking tools.
Decontamination: Wash spill area thoroughly with soap and water after material removal.
Disposal: Dispose of via licensed waste disposal contractor according to local regulations.
Handling: Handle in a chemical fume hood or well-ventilated area. Wear recommended personal protective equipment. Avoid inhaling vapor or dust, and prevent contact with skin and eyes. Do not handle near open flames or sources of ignition.
Hygiene Practices: Clean hands and exposed skin after use. Remove contaminated clothing before entering public areas.
Storage Conditions: Store tightly closed in original container. Keep in a cool, dry, and well-ventilated place, away from incompatible materials such as oxidizers and acids. Store locked up.
Technical Measures: Use corrosion-resistant storage equipment. Keep container upright and prevent leaks.
Occupational Exposure Limits: No established OSHA or ACGIH TLV value, but minimize exposure based on toxicity.
Engineering Controls: Use mechanical exhaust or local ventilation. Provide eyewash stations and safety showers.
Personal Protection: Wear chemical-resistant gloves (like nitrile or neoprene), long-sleeved protective clothing, safety goggles, and a NIOSH-certified respirator for organic vapor if exposure risk exists.
Environmental Controls: Prevent leaks or spills from escaping into the environment.
Appearance: White to off-white crystalline powder
Odor: Weak, aromatic, characteristic of chlorinated pyridines
Odor Threshold: Not established
Molecular Weight: 198.44 g/mol
pH: Not applicable (insoluble in water)
Melting Point: 66–70°C
Boiling Point: 225–227°C
Flash Point: 112°C (closed cup)
Flammability: Combustible at elevated temperatures
Auto-Ignition Temperature: Data not available
Decomposition Temperature: Above 230°C (decomposes to toxic fumes)
Vapor Pressure: 0.05 mm Hg at 25°C
Vapor Density: Not available
Solubility: Sparingly soluble in water, soluble in ethanol, acetone, chloroform
Partition Coefficient (log Kow): Estimated 3.1
Evaporation Rate: Not established
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and handling conditions.
Reactivity: Avoid strong oxidizers, acids, and bases.
Hazardous Reactions: May react with strong oxidizing agents causing fire or explosion.
Conditions to Avoid: Exposure to heat, sparks, open flames, and moisture.
Decomposition Products: Hydrogen chloride, phosgene, nitrogen oxides, and other hazardous gases.
Acute Toxicity: Oral LD50 (rat): 250–500 mg/kg. Dermal LD50 and inhalation values: not fully characterized but presumed toxic.
Skin Corrosion/Irritation: Causes irritation with possible redness and rash.
Serious Eye Damage/Irritation: Causes eye irritation, possible corneal injury.
Respiratory Sensitization: Irritates respiratory tract; may cause coughing and symptoms of acute chemical exposure.
Chronic Effects: Long-term exposure may result in liver or kidney effects, not well studied in humans.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA.
Mutagenicity: No significant mutagenic data reported.
Reproductive Toxicity: No data available; avoid unnecessary exposure.
Target Organs: Skin, eyes, respiratory tract.
Ecotoxicity: Harmful to aquatic life with long-lasting effects.
Persistence and Degradability: Poorly biodegradable. May remain in the environment for extended periods.
Bioaccumulative Potential: Moderate; expected to bioaccumulate in aquatic organisms.
Mobility in Soil: Limited mobility due to low solubility in water.
Other Adverse Effects: Avoid release to the environment. No known effects on ozone layer.
Waste Treatment Methods: Incinerate at approved facility. Do not allow into sewers or public water systems.
Contaminated Packaging: Dispose of as hazardous waste; comply with local and national regulations. Clean container thoroughly before recycling or disposal.
Special Precautions: Contact licensed waste disposal contractor for proper procedures.
Regulatory Status: Managed as hazardous waste under RCRA (U.S.). Other local legislation may apply.
UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (2,3,5-Trichloropyridine)
Transport Hazard Class: 6.1 (Toxic Substances)
Packing Group: III
Labels Required: Toxic
Environmental Hazards: Marine pollutant; notify transport authorities if shipping large amounts.
Special Precautions for User: Handle sealed and labeled. Provide documentation to carrier.
Additional Info: Not regulated for small quantities under some thresholds.
TSCA Inventory Status: Listed
SARA Title III (Sections 311/312): Acute health hazard
SARA Title III (Section 313): Not subject to reporting
RCRA Status: Hazardous waste if discarded
EPA Regulatory Information: Subject to toxic chemical regulations for workplace and environmental safety
OSHA Hazard Communication: Meets criteria for hazardous substance
State Regulations: May be subject to additional state requirements; review local regulations.
EINECS/ELINCS: Listed
Other International Regulations: Complies with REACH requirements for European Union use.
