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Product Name: 2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic acid
Synonyms: AMTA, Methoxyimino thiazole acetic acid
CAS Number: 63527-52-6
Recommended Use: Pharmaceutical intermediate; used in the synthesis of antibiotics such as cephalosporins
Supplier: Manufacturer or distributor details.
Emergency Contact: Local poison control center or medical helpline.
GHS Classification: Acute toxicity (oral and dermal), Eye irritation, Skin sensitization
Hazard Statement: Harmful if swallowed. Causes eye irritation. Can irritate skin when handled directly. Prolonged exposure may cause allergic reaction.
Pictogram: Exclamation mark (irritant)
Signal Word: Warning
Precautionary Statements: Avoid breathing dust or particles. Wear protective clothing. Wash skin after handling.
Other Hazards: Dust may cause respiratory irritation; environmental hazard if released into water bodies.
Chemical Identity: 2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic acid
Molecular Formula: C6H7N3O3S
Weight Percentage: Typically >98% pure
Impurities: May include related thiazole derivatives in trace amounts; consult certificate of analysis for specifics.
CAS Number: 63527-52-6
Inhalation: Move person to fresh air. Seek medical advice if symptoms persist, such as coughing, shortness of breath, or wheezing.
Skin Contact: Remove contaminated clothing and rinse skin thoroughly with soap and water. If irritation continues, see a doctor.
Eye Contact: Rinse eyes under running water for at least 15 minutes. Remove contact lenses after initial flushing. Call an eye specialist if irritation remains.
Ingestion: Do not induce vomiting. Rinse mouth with water and seek medical attention immediately.
Most Important Acute Symptoms: Irritation to respiratory tract, skin, and eyes; possible gastrointestinal discomfort on ingestion.
Suitable Extinguishing Media: Water spray, dry chemical powder, foam, or carbon dioxide.
Unsuitable Media: High-pressure water jets due to potential for chemical spread.
Specific Hazards: May produce toxic gases (nitrogen oxides, sulfur oxides, carbon oxides) in a fire.
Protective Equipment: Wear full protective gear and self-contained breathing apparatus.
Advice for Firefighters: Keep containers cool with water spray. Evacuate area if fire grows beyond control.
Special Procedures: Contain firefighting runoff to prevent contamination of surface water and soil.
Personal Precautions: Use gloves, goggles, and dust mask or suitable respirator. Keep unprotected persons away.
Environmental Precautions: Prevent chemical from entering drains or water bodies.
Methods for Cleaning: Sweep up and collect spilled material. Avoid creating dust. Clean spill area thoroughly with water and detergent.
Disposal of Waste: Place waste in clearly labeled, sealed container for disposal according to local regulations.
Safe Handling: Use in ventilated area. Wear suitable PPE. Minimize dust generation and accumulation.
Storage Conditions: Store in a tightly closed container at room temperature, shielded from moisture and light.
Incompatible Materials: Strong oxidizers, acids, and bases
Other Advice: Limit direct handling. Keep away from food, beverages, and animal feed.
Occupational Exposure Limits: No established exposure limits; minimize exposure by using controls.
Engineering Controls: Use chemical fume hood or local exhaust ventilation.
Personal Protective Equipment:
Eye Protection: Chemical-resistant safety glasses
Skin Protection: Gloves (nitrile or neoprene recommended), long-sleeved clothing
Respiratory Protection: Dust mask or respirator if dust risk exists
Hygiene Measures: Wash hands before meals and after use. No eating, drinking, or smoking in work area.
Appearance: White to off-white crystalline powder
Odor: Faint or none
Odor Threshold: Not determined
pH: Slightly acidic in solution
Melting Point / Freezing Point: 153-157°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, ethanol, and methanol
Relative Density: 1.59 g/cm3
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): Data not available
Decomposition Temperature: Above 160°C
Viscosity: Not applicable
Flash Point: Not flammable under normal conditions
Explosive Properties: Not classified as explosive
Oxidizing Properties: Not classified as oxidizer
Chemical Stability: Stable under recommended storage and handling conditions
Possible Hazardous Reactions: No known dangerous reactions if handled properly. Will decompose in strong acids or bases.
Conditions to Avoid: Heat, direct sunlight, exposure to moisture
Incompatible Materials: Strong oxidants, reducing agents
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon oxides generated at high temperatures or on decomposition
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: LD50 (oral, rat): >2000 mg/kg; not acutely toxic at low concentrations
Skin Corrosion/Irritation: May cause mild irritation
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory Sensitization: Prolonged inhalation may cause respiratory tract irritation
Skin Sensitization: May cause an allergic skin reaction on repeated exposure
Germ Cell Mutagenicity: Not classified based on available data
Carcinogenicity: No component listed as a known carcinogen
Reproductive Toxicity: No evidence of reproductive toxicity
STOT-single exposure: May cause respiratory irritation
STOT-repeated exposure: No organ toxicity observed in standard use
Aspiration Hazard: Not considered an aspiration hazard
Ecotoxicity: Not readily biodegradable, may pose short-term risk to aquatic organisms
Aquatic Toxicity: Data limited, but estimated to be low to moderate based on structure
Persistence and Degradability: Expected to be persistent in the environment under standard conditions
Bioaccumulative Potential: Low potential for bioaccumulation
Mobility in Soil: Mobile in aqueous solutions, may leach if improperly discarded
Other Adverse Effects: Avoid environmental release; use appropriate containment to protect groundwater and surface water resources
Disposal Methods: Collect and seal substance in container approved for hazardous waste. Dispose at certified chemical waste facility.
Contaminated Packaging: Rinse containers thoroughly. Dispose packaging in accord with official local requirements.
Recycling: Not recommended due to possible contamination risks.
Additional Advice: Don’t discard into sewer, soil, or any water body.
UN Number: Not classified as dangerous goods under transport regulations
Proper Shipping Name: 2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic acid
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazard Label: None
Special Precautions: Secure packaging against tipping and moisture during transport. Keep away from food and feedstuffs during transit.
Transport in Bulk: Follow all applicable governing statutes if shipped in large quantities.
Regulations: Subject to chemical control regulations in most jurisdictions.
Inventory Listings: May appear on TSCA (US), EINECS/ELINCS (EU), DSL/NDSL (Canada), ENCS (Japan), and other chemical inventories.
Label Requirements: Signal word “Warning,” hazard pictogram, and chemical name provided.
Other Requirements: Employer and facility must ensure training and access to Safety Data Sheet for users handling the chemical.
Customs and Import: Product classification and handling may require supporting documentation for international movement.
