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Product Name: 2,2,3,3-Tetramethylcyclopropanecarboxylic Acid
Chemical Formula: C8H14O2
CAS Number: 5745-46-4
Recommended Use: Laboratory chemical, intermediate in organic synthesis
Manufacturer Details: [Specify as appropriate]
Contact Information: Emergency telephone number available from supplier or local poison center
GHS Classification: Skin irritation, Category 2
Signal Word: Warning
Hazard Statements: May cause skin irritation. May cause eye irritation. Harmful if inhaled or swallowed.
Precautionary Statements: Wear protective gloves and eye/face protection. Avoid breathing dust or vapors. Wash exposed skin thoroughly after handling.
Pictograms: Exclamation mark
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Hazards Not Otherwise Classified: No significant hazards expected with proper use, but repeated or prolonged exposure increases risk.
Chemical Name: 2,2,3,3-Tetramethylcyclopropanecarboxylic Acid
Common Names/Synonyms: TMCPCA
Chemical Family: Carboxylic acids, cyclopropanes
Concentration: 98% or greater
Impurities/Additives: May contain traces of related cyclopropane derivatives or residual solvents from synthesis
Inhalation: Move person to fresh air. If breathing becomes difficult or stops, administer oxygen or artificial respiration and seek medical help.
Skin Contact: Remove contaminated clothing and rinse skin generously with soap and water. Seek medical attention for irritation or persistent discomfort.
Eye Contact: Rinse carefully with plenty of water for at least 15 minutes, holding the eyelids apart. Remove contact lenses if present and easy to do. Immediate medical consultation recommended.
Ingestion: Rinse mouth with water. Do not induce vomiting—seek immediate medical attention, especially if symptoms develop.
Important Symptoms/Effects: Redness, irritation, burning sensation, headache or nausea possible after significant exposure.
Advice to Physician: Treat symptomatically and provide supportive care as required.
Suitable Extinguishing Media: Use dry chemical, water spray, foam, or carbon dioxide. Choose media suitable for surrounding fire.
Unsuitable Extinguishing Media: High-volume water jets can spread contamination.
Special Hazards from Combustion: Produces toxic vapors of carbon monoxide, carbon dioxide, and possibly other organic vapors when burning.
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear.
Advice for Firefighters: Cool containers with water spray to prevent rupture from heat. Collect contaminated firefighting water separately and dispose of in accordance with regulations.
Explosion or Reactivity Concerns: Dust may form explosive mixture with air in confined spaces.
Personal Precautions: Avoid contact with skin, eyes, and inhalation of dust. Ventilate area and evacuate unnecessary personnel.
Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat, mask or respirator where needed.
Emergency Procedures: Cover spills with non-combustible absorbent (e.g., sand, vermiculite) and transfer to waste container.
Methods for Cleanup: Collect with shovel or appropriate tools, avoid raising dust. Wash residue from spill area with water after material pickup.
Environmental Precautions: Prevent material from entering drains, sewers, or waterways. Notify authorities if contamination occurs.
Handling: Use good industrial hygiene and safety practice. Work in well-ventilated area. Avoid generating dust or aerosols. Do not eat, drink, or smoke during use.
Storage: Store in a tightly closed container in a cool, dry, well-ventilated location. Keep away from incompatible substances such as strong oxidizers. Protect from light and moisture.
Incompatibilities: Strong acids, alkalis, and oxidizing agents.
Special Handling Recommendations: Keep container tightly sealed. Handle carefully to avoid spillage and minimize exposure.
Other Storage Instructions: Follow all applicable local, regional, and national regulations.
Engineering Controls: Use local exhaust ventilation or process enclosure to minimize exposure. Provide eyewash stations and safety showers.
Personal Protective Equipment:
Appearance: White to off-white crystalline powder
Odor: Mild, characteristic; faintly acidic
Odor Threshold: Not established
pH: Slightly acidic in aqueous solution
Melting Point/Range: Estimated 140–145°C (284–293°F)
Boiling Point/Range: Decomposes before boiling
Flash Point: Not flammable under normal use
Evaporation Rate: Not applicable
Flammability (Solid, Gas): Not highly flammable
Vapor Pressure: Negligible at ambient temperature
Vapor Density: Not determined
Relative Density: Approx. 1.08 g/cm³
Solubility: Low solubility in water; more soluble in organic solvents such as ethanol, ether
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not self-igniting
Decomposition Temperature: Above 200°C
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not highly reactive under normal conditions
Conditions to Avoid: Excessive heat, open flame, direct sunlight, moisture
Incompatible Materials: Strong oxidizing agents, acidic or basic substances, strong reducing agents
Hazardous Decomposition Products: Can emit carbon monoxide, carbon dioxide, organic acids and possible other toxic vapors during combustion or decomposition
Polymerization: Does not occur
Other Reactivity Information: Dust can build up static charges, posing ignition risk in rare circumstances
Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Data are limited; structurally similar compounds have low acute toxicity. May cause gastrointestinal upset if swallowed.
Skin Corrosion/Irritation: Can cause irritation, redness.
Serious Eye Damage/Irritation: Can provoke irritation, tearing, and conjunctival redness.
Respiratory Sensitization: Risk exists with dust exposure; advanced symptoms include coughing, tightness in chest.
Carcinogenicity: Not listed as a carcinogen by NTP, IARC, or OSHA
Mutagenicity: No genetic mutation reports in available data
Reproductive Toxicity: No data suggest reproductive risk.
STOT—Single Exposure: Possible irritation to skin, eyes, or respiratory system.
STOT—Repeated Exposure: Chronic or repeated contact can increase local irritation.
Other Health Hazards: No long-term studies reported. Exercise caution.
Ecotoxicity: No experimental data on aquatic toxicity. Structurally related cyclopropane acids have modest ecotoxic impact at high concentrations.
Persistence and Degradability: Expected to be partly biodegradable in environment, based on family of compounds
Bioaccumulative Potential: Not likely to bioaccumulate, owing to moderate solubility and molecular mass
Mobility in Soil: may persist in soil for short periods before degrading through microbial activity
Other Adverse Effects: No documented long-term risk to terrestrial or aquatic organisms. Discharge into waterways should be avoided.
Waste Treatment Methods: Dispose of in line with federal, state, and local regulation. Do not release into environment. Collect material and place in sealed, labeled containers for proper disposal.
Disposal of Packaging: Rinse thoroughly before recycling or disposing. Destroy packaging by incineration if local rules allow.
Special Precautions for Disposal: Consult waste disposal expert. Do not mix with incompatible waste streams.
UN Number: Not classified as dangerous goods for transport
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: Not considered marine pollutant according to IMDG code
Special Precautions for User: Secure containers tightly and protect from mechanical damage. Prevent unintentional spillage during movement.
TSCA Status: Listed or complies under TSCA
SARA Title III: Not subject to reporting under SARA Title III Sections 302, 304, 313
OSHA Status: Considered hazardous under OSHA Hazard Communication Standard
DSL/NDSL (Canada): Listed or meets requirements
EINECS/ELINCS (EU): Registered or pre-registered
California Prop 65: Not listed
Other Regulations: Follow requirements set by regional, national, and international guidelines; seek further advice if manufacturing, importing, or exporting
