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Material Safety Data Sheet: 17-Acetoxy-5Α-Androst-2,16-Diene

Identification

Product Name: 17-Acetoxy-5Α-Androst-2,16-Diene
Chemical Formula: C21H30O2
Synonyms: Androst-2,16-diene-17-acetoxy-5α
Recommended Use: Chemical research, intermediate in synthesis
Supplier: Contact details available upon request
Emergency Telephone Number: Provided by supplier or local emergency services

Hazard Identification

Classification: Not classified according to GHS criteria, but exposure may cause irritation
Label Elements: No pictogram required, handle with caution
Signal Word: None mandated, prudent handling essential
Hazard Statements: May cause skin, respiratory, and eye irritation on direct contact
Precautionary Statements: Wear protective gloves and eye protection, avoid inhalation of dust, wash thoroughly after handling

Composition / Information on Ingredients

Chemical Name: 17-Acetoxy-5Α-Androst-2,16-Diene
CAS Number: 566-48-9
Concentration: 98% or higher (as pure research chemical)
Impurities: Organic solvents or byproducts may be present in trace amounts, non-hazardous contaminants below 1%

First Aid Measures

Inhalation: Move to fresh air, seek medical attention if symptoms like coughing or breathlessness persist
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing, seek medical care for irritation
Eye Contact: Rinse under gentle running water for at least 15 minutes, obtain medical advice if irritation remains
Ingestion: Rinse mouth with water, do not induce vomiting, get immediate medical help
Advice for Doctors: Treat symptomatically based on clinical judgment and observed effects

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry powder, alcohol-resistant foam, water spray
Unsuitable Media: Direct water jet could spread burning material
Hazardous Combustion Products: Possibly carbon monoxide, carbon dioxide, acrid fumes
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Risks: Avoid inhaling fumes, move containers from fire area if safe, cool exposed containers with water spray

Accidental Release Measures

Personal Precautions: Put on gloves, goggles, and a lab coat; ventilate area; avoid dust formation
Environmental Precautions: Prevent spillage from entering waterways or soil
Methods for Cleanup: Sweep up carefully, avoid dust generation, place collected material in suitable waste container, clean area with moist absorbent material
Notification: Report major spills to local environmental authorities according to regulations

Handling and Storage

Handling: Work in a chemical fume hood, wear personal protective equipment, avoid direct contact
Storage Conditions: Store in a tightly sealed container under cool, dry, and well-ventilated conditions
Incompatibilities: Keep away from strong oxidizing agents, heat sources, and direct sunlight
Other Measures: Label clearly, restrict access to trained personnel only

Exposure Controls and Personal Protection

Exposure Limits: No specific occupational exposure limits defined for this compound
Engineering Controls: Use chemical fume hood, local exhaust ventilation
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat, and dust mask for handling powders
Hygiene Measures: Wash hands before breaks, after work, and before eating or drinking; avoid touching face

Physical and Chemical Properties

Appearance: White or off-white crystalline powder
Odor: Odorless or faint organic smell
Molecular Weight: 314.46 g/mol
Melting Point: 169–172 °C
Boiling Point: Decomposes before boiling
Solubility: Poorly soluble in water, soluble in common organic solvents such as ethanol, chloroform, and acetone
pH: Not applicable
Vapor Pressure: Not available
Partition Coefficient (log Pow): Not determined
Flash Point: No data available
Density: Not available
Evaporation Rate: Not determined

Stability and Reactivity

Chemical Stability: Stable in closed container under recommended storage conditions
Thermal Decomposition: May decompose above 160 °C releasing toxic fumes
Incompatible Materials: Strong oxidizing agents, strong acids
Polymerization: No hazardous polymerization expected under normal conditions
Stability Note: Minimize exposure to light and air to preserve material integrity

Toxicological Information

Acute Toxicity: No comprehensive toxicity data available; avoid unnecessary exposure
Skin Irritation: May cause mild irritation on prolonged contact
Eye Irritation: Contact may result in redness or watering
Respiratory: Powder inhalation could irritate upper respiratory tract
Chronic Exposure: No long-term studies known, avoid repeated exposure; possible endocrine activity due to steroid structure
Sensitization: No data found, precautionary handling advised
Carcinogenicity: Not listed by NTP, IARC, OSHA as carcinogenic
Mutagenicity and Reproductive Effects: None reported in available studies

Ecological Information

Aquatic Toxicity: No measured data found, potential risk to aquatic organisms if released in large quantities
Persistence and Degradability: Likely slow to degrade in the environment, use caution to prevent contamination
Bioaccumulation Potential: Unknown, minimize large-scale release
Other Effects: Do not permit entry into soil, drains, water sources

Disposal Considerations

Waste Treatment Methods: Dispose of through licensed chemical waste disposer
Contaminated Packaging: Dispose in accordance with local, regional, and national regulations
Special Precautions: Wear protective equipment, prevent dust formation during disposal
Environmental Caution: Do not discharge residue into soil or waterways

Transport Information

UN Number: Not regulated under ADR, DOT, IMDG, or IATA for transport
Proper Shipping Name: Not classified as hazardous
Transport Hazard Class: None assigned
Packing Group: Not assigned
Special Precautions for User: Keep in original sealed container, handle with care to avoid container damage or leaks during transport
Environmental Hazards: Not considered a marine pollutant
Transport in Bulk: Not applicable

Regulatory Information

Hazard Classification: This substance not listed as hazardous under major chemical control regulations
Chemical Inventory Status: May not be listed on local or national chemical inventories, check for applicability in specific jurisdictions
Safety, Health, and Environmental Regulations: Compliance with workplace safety rules and environmental legislation essential
International Regulations: Not subject to specific export restrictions, but reporting may be required for laboratory chemical use
Other Labeling Requirements: Assign safety labeling according to institutional policy and national guidelines